Results 71 to 80 of about 2,205 (198)
Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications
Cell Proliferation, Volume 58, Issue 10, October 2025.Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su +5 more
wiley +1 more source
Inhibition of galactonolactone dehydrogenase activity by lycorine
, 1996 Galactonolactone dehydrogenase, a mitochondrial enzyme catalyzing the last step in ascorbate biosynthesis, is strongly inhibited by lycorine. A concentration of 10 microM of the alkaloid fully inhibits the activity of the enzyme.
De Gara L. +2 more
core
Influenza and Other Respiratory Viruses, Volume 19, Issue 10, October 2025.ABSTRACT Background Natural alkaloids are a structurally diverse class of bioactive compounds with significant therapeutic potential. This study aimed to evaluate the in vitro antiviral activity of various natural alkaloids against coronaviruses, clarify molecular effects via bioassays and docking, and explore structure–activity relationships.
Marcela Safratova +11 more
wiley +1 more source
Preparation of Secolycorines against Acetylcholinesterase
, 2008 5,6-Secolycorines possessing a 5,6-dihydrophenanthridine skeleton were facilely prepared from lycorine through chemical transformations, mainly including N-alkylation, Hofmann degradation type reaction, reductive cleavage of trichloroethylcarbonyl moiety,
李水盛;林少紅;林榮信 +1 more
core
"In vivo" inhibition of galactono-g-lactone conversion to ascorbate by lycorine
, 1994 Maize embryos are endowed with the ascorbate biosynthetic system and the last enzyme of the pathway, galactono oxidase (or dehydrogenase), is very active; L-galactono-γ-lactone addition gives rise to a 3-fold increase in cellular ascorbate content ...
LISO R +4 more
core +1 more source
Towards the asymmetric total synthesis of (−)-lycorine [PDF]
, 2015 The application of organocatalysis has expanded significantly in recent years. Organocatalysts can give good enantioselectitvity and hence provide an efficient access to chiral building blocks for organic synthesis.
Nieh, Ling-Fu
core +1 more source
Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry
ChemMedChem, Volume 20, Issue 18, September 25, 2025.This review highlights the rationale behind multitarget drug design as a promising approach to address diseases with complex etiologies. By combining pharmacophore features from different single‐target drugs, multitarget compounds can interact with multiple biological targets simultaneously.
Sadık Hüseyin Cemali +7 more
wiley +1 more source
Disruption of Spike Priming in Virus Entry: Tetrandrine as a Pan‐Coronavirus Inhibitor
MedComm, Volume 6, Issue 9, September 2025.Tetrandrine inhibits the infection of HCoV‐OC43, HCoV‐229E, SARS‐CoV‐2, and its major variants by blocking virus entry. Specifically, tetrandrine breaks the interaction between TMPRSS2 and Spike, therefore suppress its priming and the following membrane fusion, and induces Spike to degradation.
Kun Wang +9 more
wiley +1 more source
Evaluation of the antispasmodic and antioxidant activities of an alkaloid extracted from Pancratium foetidum Pom. (Moroccan Endemic Amaryllidaceae) [PDF]
E3S Web of ConferencesLycorine is a natural alkaloid extracted from the Amaryllidaceae plant family. It has been reported to exhibit a wide range of physiological effects, including the potential effect against cancer.
Bendaif Hajar +9 more
doaj +1 more source
, 2018 Malignant melanoma, one of the most aggressive skin cancers, has a very high mortality rate. Currently, the number of drugs to treat melanoma is low. Although new immunotherapeutic approaches based on the use of antibodies against immune checkpoints have
Qun-Qun Jiang, Wei-Bing Liu
core +1 more source