Results 71 to 80 of about 3,343 (218)

Lycorine impedes 7,12-dimethylbenz(a)anthracene exposed hamster oral carcinogenesis through P13K/Akt and NF-κB inhibition

Türk Biyokimya Dergisi, 2022
Oncogenic signaling pathways that are activated abnormally play a key activity in tumor initiation and development. This research aimed to examine the preventive efficiency of lycorine in the buccal pouch hamster tumor model based on its capacity to ...
Gan Yi, He Ai’e, Zhu Lilei, Yao Yao, Lv Chunhua   +4 more
doaj   +1 more source

Environmental and phytohormone modulation of organ‐specific specialized metabolite profiles in the dryland tree Erythrina velutina

Plant Biology, Volume 27, Issue 7, Page 1326-1340, December 2025.
Erythrina velutina organ‐specific specialized metabolism is modulated by environmental stress and phytohormones to mitigate effects of the harsh semi‐arid habitat. Abstract Erythrina velutina is a tree that thrives in the shallow rocky soils of the dry and hot Caatinga, a unique Brazilian biome.
D. S. Chacon, B. Bonilauri, C. T. da Costa, J. Vilasboa, M. Koetz, L. Pinto, J. A. S. Zuanazzi, R. B. Giordani, A. G. Fett‐Neto   +8 more
wiley   +1 more source

Laboratory evaluation of natural and synthetic aromatic compounds as potential attractants for male mediterranean fruit fly, ceratitis capitata [PDF]

, 2019
Ceratitis capitata, the Mediterranean fruit fly, is one of the most serious agricultural pests worldwide responsible for significant reduction in fruit and vegetable yields. Eradication is expensive and often not feasible. Current control methods include
Cimmino, A., Epsky, N. D., Evidente, A., Kendra, P. E., Masi, M., Niogret, J., Nocera, P., Tabanca, N.   +7 more
core   +1 more source

Preclinical Screening Platform Identifies Azatadine‐Dimaleate as a Potent Repurposed Therapeutic Against SARS‐CoV‐2 Infection

Journal of Medical Virology, Volume 97, Issue 11, November 2025.
ABSTRACT The emergence of SARS‐CoV‐2 posed a major global public health threat, necessitating urgent development of therapeutics. Despite vaccine availability, continuous emergence of viral variants with enhanced transmissibility and immune escape capabilities, and consequential impacts on health services, requires effective antiviral therapeutics ...
Ahlam Ali, David Courtney, Lindsay Broadbent, Parul Sharma, Connor G. G. Bamford, Sheerien Manzoor, Olivier Touzelet, Conall McCaughey, Adam Kirby, Eleanor Bentley, Anja Kipar, Ken I. Mills, James P. Stewart, Ultan F. Power   +13 more
wiley   +1 more source

Can phylogeny predict chemical diversity and potential medicinal activity of plants? A case study of amaryllidaceae [PDF]

, 2012
Background During evolution, plants and other organisms have developed a diversity of chemical defences, leading to the evolution of various groups of specialized metabolites selected for their endogenous biological function.
Birkholm, Trine, Christensen, Soren Brogger, Jager, Anna K., Meerow, Alan W., Molander, Marianne, Molgaard, Per, Petersen, Gitte, Rasmussen, Nina, Ronsted, Nina, Stafford, Gary I., Symonds, Matthew R. E., van Staden, Johannes   +11 more
core   +3 more sources

In search of a cytostatic agent derived from the alkaloid lycorine: Synthesis and growth inhibitory properties of lycorine derivatives [PDF]

Bioorganic & Medicinal Chemistry, 2011
As a continuation of our studies aimed at the development of a new cytostatic agent derived from an Amaryllidaceae alkaloid lycorine, we synthesized 32 analogues of this natural product. This set of synthetic analogues included compounds incorporating selective derivatization of the C1 versus C2 hydroxyl groups, aromatized ring C, lactamized N6 ...
Evdokimov N. M., Lamoral Theys D., Mathieu V., ANDOLFI, ANNA, Frolova L. V., Pelly S. C., van Otterlo W. A. L., Magedov I. V., Kiss R., EVIDENTE, ANTONIO, Kornienko, A.   +10 more
openaire   +4 more sources

Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

Cell Proliferation, Volume 58, Issue 10, October 2025.
Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su, Yanlin Li, Zihao Zhou, Bing Feng, Haiming Chen, Guangjuan Zheng   +5 more
wiley   +1 more source

Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis. [PDF]

, 2016
The use of photochemical transformations is a powerful strategy that allows for the formation of a high degree of molecular complexity from relatively simple building blocks in a single step. A central feature of all light-promoted transformations is the
Kärkäs, Markus D., Porco, John A., Stephenson, Corey R.J.   +2 more
core   +2 more sources

Anticoronavirus Isoquinoline Alkaloids: Unraveling the Secrets of Their Structure–Activity Relationship

Influenza and Other Respiratory Viruses, Volume 19, Issue 10, October 2025.
ABSTRACT Background Natural alkaloids are a structurally diverse class of bioactive compounds with significant therapeutic potential. This study aimed to evaluate the in vitro antiviral activity of various natural alkaloids against coronaviruses, clarify molecular effects via bioassays and docking, and explore structure–activity relationships.
Marcela Safratova, Yu‐Li Chen, Anna Hostalkova, Jakub Chlebek, Chung‐Fan Hsieh, Bing‐Hung Chen, Lucie Cahlikova, Stefan Kosturko, Anders Backlund, Jim‐Tong Horng, Tsong‐Long Hwang, Michal Korinek   +11 more
wiley   +1 more source

Synthesis, characterization, antimicrobial and antitumor activities of sucrose Octa(N-ethyl)carbamate [PDF]

, 2016
Sucrose octa(N-ethyl)carbamate was synthesized directly from sucrose and ethyl isocyanate, and its structure was confirmed by various analytical methods, such as 1H and 13C NMR, FTIR, m.p., MS, and optical rotation.
Barros, M. Teresa, Calhelha, Ricardo C., Ferreira, Isabel C.F.R., Petrova, Krasimira T., Raposo, Claudia, Soković, Marina   +5 more
core   +1 more source