Results 51 to 60 of about 2,205 (198)

An overview on the chemical and biological aspects of lycorine alkaloid [PDF]

Journal of Advanced Biomedical and Pharmaceutical Sciences, 2018
Amaryllidaceae plants are currently appreciated as a plentiful source of unique bioactive alkaloids. Among them, lycorine is one of the major pyrrolophenanthridine alkaloids commonly isolated from different species of this family.
Marwa Khalifa, Eman Attia, John Fahim, Mohamed Kamel   +3 more
doaj   +1 more source

Regulated Cell Death in Idiopathic Pulmonary Fibrosis

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
This graphical abstract illustrates regulated cell death (RCD) across key pulmonary cell types—including alveolar epithelial cells, fibroblasts, macrophages, and endothelial cells—modulated through a dynamic death modulation network within the IPF microenvironment.
Xiaoyue Pan, Liu Yang, Man Zhao, Yanlin Zhou, Cong Xia, Huibing Liu, Yuqi Wang, Hui Lian, Bin Li, Lan Wang, Guoying Yu   +10 more
wiley   +1 more source

Flavonoid Oxime Carbamate Derivatives: Reversal of Multidrug Resistance in Cancer Cells

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A set of 23 new flavonoid oxime carbamates was synthesized and evaluated as multidrug resistance (MDR) reversers in ABCB1‐transfected mouse lymphoma cells. All derivatives strongly inhibited P‐glycoprotein (P‐gp) efflux activity in a transport assay, while most selected compounds behaved as ATPase inhibitors. In drug combination assays, they interacted
Filipa Barbosa, Gabriella Spengler, Noémi Bózsity, Nikoletta Szemerédi, István Zupkó, Maria‐José U. Ferreira   +5 more
wiley   +1 more source

Biosynthetically‐Inspired Oxidative Cleavage Platform Enables Rapid Access to Diverse and Architecturally Complex Chemotypes From Indole Alkaloids

ChemistryEurope, Volume 4, Issue 4, April 2026.
We report a biosynthesis‐inspired ring distortion approach that involves oxidative ring cleavage, ring rearrangement, and ring expansion reactions from a diverse collection of indole alkaloids and derivatives. This chemical synthesis approach led to the synthesis of >25 distinct chemotypes from 14 indole alkaloids.
Derek A. Leas, Eli S. Levit, Alexis A. Bragg, Taylor A. Gerrein, Khalil A. Abboud, Pingrong Wei, Lukasz M. Dobrzycki, Robert W. Huigens III   +7 more
wiley   +1 more source

Biotransformation of Lycorine By Cryptococcus-terreus To A Stimulant of Budding In Cryptococcus-dimennae

, 1991
Lycorine stimulates budding in Cryptococcus terreus. In lycorine-treated cultures, there is an increase in dry weight and even more in the number of cells. Cryptococcus dimennae is not affected by lycorine.
I. GARUCCIO, A. Evidente, EVIDENTE, ANTONIO, S. ONOFRI, O. ARRIGONI   +4 more
core   +1 more source

The Protective Effect of Exogenous Ascorbic Acid on Photosystem Inhibition of Tomato Seedlings Induced by Salt Stress

Plants, 2023
This study investigated the protective effects of exogenous ascorbic acid (AsA, 0.5 mmol·L−1) treatment on salt-induced photosystem inhibition in tomato seedlings under salt stress (NaCl, 100 mmol·L−1) conditions with and without the AsA inhibitor ...
Xianjun Chen, Hongwei Han, Yundan Cong, Xuezhen Li, Wenbo Zhang, Wenliang Wan, Jinxia Cui, Wei Xu, Ming Diao, Huiying Liu   +9 more
doaj   +1 more source

Targeting C/EBPβ to Suppress Myocardial Fibrosis in Hypertensive Heart Disease: Role of the ACE2/Ang‐(1–7) Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Hypertensive heart disease is characterised by ventricular remodelling and interstitial fibrosis, in which dysregulation of the renin–angiotensin system (RAS) plays a pivotal role. This study investigated whether the transcription factor CCAAT/enhancer‐binding protein β (C/EBPβ) attenuates hypertensive myocardial fibrosis and remodelling by ...
Yuanyuan Tie, Zehao Lin, Ming Zhang, Bincheng Ren, Donggang Han, Kexin Li, Ping Jin, Dengfeng Gao   +7 more
wiley   +1 more source

Galantamine Quantity and Alkaloid Profile in the Bulbs of Narcissus tazetta and daffodil cultivars (Amaryllidaceae) Grown in Israel

Metabolites, 2021
Alkaloids produced by the bulbs of the Amaryllidaceae are a source of pharmaceutical compounds. The main alkaloid, galantamine, is a reversible acetylcholinesterase inhibitor and allosteric nicotinic receptor modulator, which slows cognitive and ...
Dana Atrahimovich, Raviv Harris, Ron Eitan, Menashe Cohen, Soliman Khatib   +4 more
doaj   +1 more source

Multiple biological functions and pharmacological effects of lycorine [PDF]

Science China Chemistry, 2013
Lycorine is the major active component from the amaryllidaceae family plant Lycoris radiate, a represent traditional Chinese medicinal herb, and is one of the typical alkaloids with pyrrolophenanthridine nucleus core. Lycorine has drawn great interest in medicinal field due to its divergent chemical structures and multiple biological functions, as well
Cao, ZhiFei, Yang, Ping, Zhou, QuanSheng
openaire   +2 more sources

Comparative multi‐omics in female mice reveals tissue‐specific vulnerabilities to chronic alcohol intake

Alcohol, Clinical and Experimental Research, Volume 50, Issue 2, February 2026.
Using mice, we applied multi‐omics to compare liver and skeletal muscle after chronic alcohol consumption. The liver responded more strongly across genes, proteins, and metabolites, with a lowered PC:PE ratio. Muscle showed inflammation, extracellular matrix activation, impaired mitochondrial energetics, and an elevated PC:PE ratio. Lipidomics affected
Craig R. G. Willis, Muni Swamy Ganjayi, Austin M. Brown, Samantha E. Moser, Nathaniel J. Szewczyk, Brian C. Clark, Cory W. Baumann   +6 more
wiley   +1 more source