Results 31 to 40 of about 2,205 (198)
Poultry Science, 2021 : Duck tembusu virus (DTMUV) was firstly identified in 2010 in China; since then, it has caused enormous economic loss to breeding industry. Great efforts have been made to develop drugs and vaccines against DTMUV.
Xuan Lv +11 more
doaj +1 more source
Dual Targeting of DNA and EGFR by ZYH005 Induces DNA Damage and Mitotic Catastrophe in Glioblastoma. [PDF]
MedComm (2020)ZYH005 exerts potent anti‐glioblastoma activity through a dual mechanism: intercalation‐mediated DNA damage and targeted inhibition of EGFR, leading to cell cycle arrest and mitotic catastrophe. ABSTRACT Glioblastoma multiforme (GBM) is an aggressive, therapy‐resistant brain tumor with limited treatment options.
Huang J +12 more
europepmc +2 more sources
Lycorine Inhibits Influenza Virus Replication by Affecting Nascent Nucleoporin Nup93 Synthesis. [PDF]
Int J Mol SciThe influenza A virus (IAV) is a major cause of recurrent seasonal epidemics and global pandemics, posing a significant threat to public health. Although lycorine has demonstrated broad-spectrum antiviral activity, its specific mechanisms of action ...
Yan H +5 more
europepmc +2 more sources
Lycorine inhibits angiogenesis by docking to PDGFRα
BMC Cancer, 2022 AbstractLycorine (Lyc) is a natural alkaloid derived from medicinal plants of the Amaryllidaceae family. Lyc has been reported to inhibit the recurrence and metastasis of different kinds of tumors. However, Lyc’s effect on angiogenesis and its specific mechanism are still not clear. This study was designed to test the antiangiogenesis effect of Lyc and
Fei Lv, XiaoQi Li, Ying Wang
openaire +3 more sources
Effect of lycorine on the structure and function of hepatoma cell membrane in vitro and in vivo
Biotechnology & Biotechnological Equipment, 2020 Lycorine is an isoquinoline alkaloid in Amaryllidaceae with antitumor, antibacterial, antiviral, diuretic and cardiovascular effects. This study explored the antitumor mechanism of lycorine in vitro and in vivo by focusing on its effects on tumor cell ...
Guosong Xin +8 more
doaj +1 more source
Lycorine: a eukaryotic termination inhibitor?
Journal of Biological Chemistry, 1986 The effect of the alkaloid lycorine on viral protein synthesis was studied in poliovirus-infected HeLa cells. The incorporation of [3H]leucine was inhibited by lycorine in a dose-dependent way, although lycorine never completely abolished translation. Using polyacrylamide gel electrophoresis, the viral proteins were identified as derived from the P1 (5'
Boeye, Albert +3 more
openaire +4 more sources
Cytotoxicity Studies of Lycorine Alkaloids of the Amaryllidaceae [PDF]
Natural Product Communications, 2014 The plant family Amaryllidaceae is renowned for its unique alkaloid constituents which possess a significant array of structural diversity. Several of these alkaloids are known for their interesting biological properties, of which galanthamine and pancratistatin have acquired a privileged status due to their relevance in the pharmaceutical arena.
Jerald J, Nair, Johannes, van Staden
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Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition
Cancer Cell International, 2012 Background Lycorine, a natural alkaloid extracted from Amaryllidaceae, has shown various pharmacological effects. Recent studies have focused on the potential antitumor activity of lycorine. In our previous study, we found that lycorine decrease the cell
Li Lv +8 more
doaj +1 more source
ERK Inhibition Promotes Engraftment of Allografts by Reprogramming T‐Cell Metabolism
Advanced Science, 2023 Extracellular regulated protein kinases (ERK) signaling is a master regulator of cell behavior, life, and fate. Although ERK pathway is shown to be involved in T‐cell activation, little is known about its role in the development of allograft rejection ...
Xiaosheng Tan +15 more
doaj +1 more source
Horticulturae, 2023 Lycorine is an important Amaryllidaceae alkaloid showing anti-cancerous activity on numerous cell lines; and it also demonstrates antiviral activity against several viruses including SARS-CoV-2 responsible for COVID-19.
Rukaya Syeed +8 more
doaj +1 more source