Results 11 to 20 of about 3,343 (218)

Up-regulation of p21 and TNF-α is mediated in lycorine-induced death of HL-60 cells [PDF]

Cancer Cell International, 2010
Background Leukemia is one of the most life-threatening cancers today, and acute promyelogenous leukemia (APL) is a common type of leukemia. Many natural compounds have already been found to exhibit significant anti-tumor effects.
He Yan, Shi Bi-Wei, Hu Ji-liang, Liu Jing, Hu Wei-Xin   +4 more
doaj   +4 more sources

Comparative Analysis of Lycorine in Wild Plant and Callus Culture Samples of Hymenocallis littoralis by HPLC-UV Method [PDF]

The Scientific World Journal, 2014
The Hymenocallis littoralis, an ornamental and medicinal plant, had been traditionally used for wound healing. In the present study, an analytical method using HPLC with ultraviolet detection was developed for the quantification of lycorine in the ...
Sreeramanan Subramaniam, Jeevandran Sundarasekar, Geethaa Sahgal, Vikneswaran Murugaiyah   +3 more
doaj   +5 more sources

Lycorine inhibits glioblastoma multiforme growth through EGFR suppression [PDF]

Journal of Experimental & Clinical Cancer Research, 2018
Background Lycorine has been revealed to inhibit the development of many kinds of malignant tumors, including glioblastoma multiforme (GBM). Although compelling evidences demonstrated Lycorine’s inhibition on cancers through some peripheral mechanism, in-
Jia Shen, Tao Zhang, Zheng Cheng, Ni Zhu, Hua Wang, Li Lin, Zexia Wang, Haotian Yi, Meichun Hu   +8 more
doaj   +3 more sources

Lycorine Derivative Inhibits SARS-CoV-2 Replication by Reducing -1 Programmed Ribosomal Frameshifting via Targeting ZAP. [PDF]

MedComm (2020)
The present study evaluated the antiviral potential of various lycorine derivatives and identified compound 7 as a promising candidate. Compound 7 demonstrated strong antiviral efficacy against both the original SARS‐CoV‐2 and its variants in vitro and in vivo.
Du T, Liu R, Zhang X, Shen L, Tang C, Wang J, Cheng Y, Yu W, Yin B, Lu S, Pan X, Peng X.   +11 more
europepmc   +2 more sources

Systematic Proteomic Characterization of EV-A71-Infected Mice Identifies Dynamic Molecular Changes and Therapeutic Targets. [PDF]

MedComm (2020)
Time‐resolved multi‐omics of EV‐A71‐infected BALB/c mice uncovered dynamic host responses, revealing rapid neutrophil extracellular traps (NETs) activation as a key event. Screened drugs (kinase inhibitors) suppressed viral replication in vitro and in vivo, suggesting the promise of targeting host phosphorylation networks as a viable antiviral strategy.
Peng W, Wang Q, Zhao B, Zhang L, Wu J, Wei X, Rong N, Wang Z, Liu K, Liu J, Yang J, Liu J.   +11 more
europepmc   +2 more sources

HPLC - DAD Analysis of Lycorine in Amaryllidaceae Species [PDF]

Natural Product Communications, 2010
Lycorine, the most frequent alkaloid found in Amaryllidaceae plants, has been proven to have various biological activities. Therefore, it is important to quantify this compound in Amaryllidacaeae species.
Gulen Irem Kaya, Derya Cicek, Buket Sarıkaya, Mustafa Ali Onur, Nehir Unver Somer   +4 more
doaj   +4 more sources

Dual Targeting of DNA and EGFR by ZYH005 Induces DNA Damage and Mitotic Catastrophe in Glioblastoma. [PDF]

MedComm (2020)
ZYH005 exerts potent anti‐glioblastoma activity through a dual mechanism: intercalation‐mediated DNA damage and targeted inhibition of EGFR, leading to cell cycle arrest and mitotic catastrophe. ABSTRACT Glioblastoma multiforme (GBM) is an aggressive, therapy‐resistant brain tumor with limited treatment options.
Huang J, Zhang Z, Xiao Y, Zhao Z, Luo Z, Liu J, Lai S, Song C, Feng S, Zhang S, Yu X, Tong Q, Zhang Y.   +12 more
europepmc   +2 more sources

In Vitro Inhibition of Alphaviruses by Lycorine [PDF]

Virologica Sinica, 2021
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. As an emerging virus, CHIKV imposes a threat to public health. Currently, there are no vaccines or antivirals available for the prevention of CHIKV infection. Lycorine, an alkaloid from Amaryllidaceae plants, has antiviral activity against a number of viruses such as coronavirus, flavivirus and ...
Na Li, Zhen Wang, Rui Wang, Zhe-Rui Zhang, Ya-Nan Zhang, Cheng-Lin Deng, Bo Zhang, Lu-Qing Shang, Han-Qing Ye   +8 more
openaire   +2 more sources

Lycorine Derivatives Against Trichomonas vaginalis [PDF]

Chemical Biology & Drug Design, 2012
Six lycorine derivatives were prepared, characterized, and evaluated for their in vitro anti‐Trichomonas vaginalis activity. Compounds bearing an acetyl (2), lauroyl (3), benzoyl (4 and 5), and p‐nitrobenzoyl (6 and 7) groups were synthesized. The best activity was achieved with lycorine esterified at C‐2 position with lauroyl group.
Raquel B, Giordani, Celso O R, Junior, Jean P, de Andrade, Jaume, Bastida, Jose A S, Zuanazzi, Tiana, Tasca, Mauro V, de Almeida   +6 more
openaire   +2 more sources

Lycorine Ameliorates Thioacetamide-Induced Hepatic Fibrosis in Rats: Emphasis on Antioxidant, Anti-Inflammatory, and STAT3 Inhibition Effects

Pharmaceuticals, 2022
Liver fibrosis is a foremost medical concern worldwide. In Saudi Arabia, numerous risk factors contribute to its high rates. Lycorine—a natural alkaloid—has antioxidant, anti-inflammatory, and antitumor activates. It has been reported to inhibit STAT3 in
Huda Mohammed Alkreathy, Ahmed Esmat
doaj   +1 more source