Results 11 to 20 of about 2,205 (198)
Lycorine inhibits glioblastoma multiforme growth through EGFR suppression
Journal of Experimental & Clinical Cancer Research, 2018 Background Lycorine has been revealed to inhibit the development of many kinds of malignant tumors, including glioblastoma multiforme (GBM). Although compelling evidences demonstrated Lycorine’s inhibition on cancers through some peripheral mechanism, in-
Jia Shen +8 more
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Lycorine Displays Potent Antitumor Efficacy in Colon Carcinoma by Targeting STAT3
Frontiers in Pharmacology, 2018 Signal transducer and activator of transcription 3 (STAT3) is an attractive therapeutic target for cancer treatment. In this study, we identify lycorine is an effective inhibitor of STAT3, leading to repression of multiple oncogenic processes in colon ...
Song Wu +14 more
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Purification of the Alkaloid Lycorine and Simultaneous Analysis of Ascorbic Acid and Lycorine by Micellar Electrokinetic Capillary Chromatography [PDF]
Analytical Biochemistry, 1998 The pyrrolophenanthridine alkaloid lycorine has frequently been used as a specific inhibitor to help elucidate the function of ascorbic acid (vitamin C) in a wide range of biological processes. It was recently reported that this function can be exercised by inhibiting the activity of L-galactono-1,4-lactone dehydrogenase, the terminal enzyme of ...
M W, Davey +5 more
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Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication
Virology Journal, 2011 Human enterovirus 71 (EV71) infection causes hand, foot and mouth disease in children under 6 years old and this infection occasionally induces severe neurological complications. No vaccines or drugs are clinical available to control EV71 epidemics.
Qin Chuan +5 more
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Pharmacological Research, 2023 Lycorine, an isoquinoline alkaloid can exhibit significant anti-cancer effects. The present study was conducted to illustrate the underlying mechanisms of action of lycorine on breast carcinoma under in vitro and in vivo settings Tandem Mass Tag assay ...
Yanfang Sun +7 more
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Pharmaceuticals, 2022 Liver fibrosis is a foremost medical concern worldwide. In Saudi Arabia, numerous risk factors contribute to its high rates. Lycorine—a natural alkaloid—has antioxidant, anti-inflammatory, and antitumor activates. It has been reported to inhibit STAT3 in
Huda Mohammed Alkreathy, Ahmed Esmat
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Up-regulation of p21 and TNF-α is mediated in lycorine-induced death of HL-60 cells [PDF]
Cancer Cell International, 2010 Background Leukemia is one of the most life-threatening cancers today, and acute promyelogenous leukemia (APL) is a common type of leukemia. Many natural compounds have already been found to exhibit significant anti-tumor effects.
He Yan +4 more
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Chemistry Central Journal, 2012 Background Alzheimer’s disease (AD) is a neurologically degenerative disorder that affects more than 20 million people worldwide. The selective butyrylcholinesterase (BChE) inhibitors and bivalent cholinesterase (ChE) inhibitors represent new treatments ...
Wang Yue-Hu +4 more
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Tandem mass tag-based quantitative proteomic analysis of lycorine treatment in highly pathogenic avian influenza H5N1 virus infection [PDF]
PeerJ, 2019 Highly pathogenic H5N1 influenza viruses (HPAIV) cause rapid systemic illness and death in susceptible animals, leading to a disease with high morbidity and mortality rates. Although vaccines and drugs are the best solution to prevent this threat, a more
Li Yang +8 more
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Asian Pacific Journal of Reproduction, 2015 Objective: To investigate the differential of protein expression in CCl4 induced mice treated with lycorine. Methods: The present study was carried out to identify the differentially expressed protein in carbon tetrachloride (CCl4) induced oxidative ...
Soundarrajan Ilavenil +7 more
doaj +2 more sources