Uncover the anticancer potential of lycorine [PDF]
Chinese MedicineBackground Natural products have a long history in drug discovery. Lycorine is an alkaloid derived from Amaryllidaceae plants, demonstrating significant pharmacological potential.
Yan-Ming Zhang +7 more
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Lycorine inhibits the proliferation of acute myeloid leukemia cells by upregulating the expression of THBS1 [PDF]
Annals of HematologyTo clarify the biological roles of the putative target thrombospondin-1 (THBS1) and the impact of the traditional Chinese medicine monomer Lycorine on acute myeloid leukemia (AML) cells. The AML cell lines HL-60 and THP-1 were used in vitro to assess the
Lunbi Wu +9 more
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Lycorine ameliorates liver steatosis, oxidative stress, ferroptosis and intestinal homeostasis imbalance in MASLD mice [PDF]
Molecular MedicineBackground Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease worldwide and few drugs are available for its treatment.
Ziwen Wang +9 more
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Amaryllidaceae Alkaloids and Phenolic Acids Identification in Leucojum aestivum L. Plant Cultures Exposed to Different Temperature Conditions [PDF]
MoleculesAmaryllidaceae alkaloids are of notable pharmacological relevance. For instance, galanthamine is used in the treatment of Alzheimer’s disease, while other alkaloids (lycorine, crinine, etc.) derived from Amaryllidaceae plants are also of great interest ...
Agata Ptak +7 more
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Lycorine Displays Potent Antitumor Efficacy in Colon Carcinoma by Targeting STAT3
Frontiers in Pharmacology, 2018 Signal transducer and activator of transcription 3 (STAT3) is an attractive therapeutic target for cancer treatment. In this study, we identify lycorine is an effective inhibitor of STAT3, leading to repression of multiple oncogenic processes in colon ...
Yuling Qiu, Sangho Koo, Haiyang Yu
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Exploring the safety of lycorine in the central nervous system and its impact on pain-like behaviors in mice [PDF]
Scientific ReportsAlkaloid analgesics have been associated with adverse effects on the central nervous system (CNS). Therefore, it is crucial to characterize the effects of alkaloid analgesics.
Hasriadi Hasriadi +4 more
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NMR Metabolomic Profiling of Differentiated SH-SY5Y Neuronal Cells: Amyloid-β Toxicity and Protective Effects of Galantamine and Lycorine [PDF]
CellsAlzheimer’s disease (AD) is a multifactorial neurodegenerative disorder characterized by metabolic dysregulation, oxidative stress, amyloid-β (Aβ) aggregation, metal dyshomeostasis, and mitochondrial dysfunction.
Arian Kola +5 more
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Lycorine Inhibits Hypertrophic Scar Formation by Inducing ROS-Mediated Apoptosis
Frontiers in Bioengineering and Biotechnology, 2022 Background: Hypertrophic scar (HS) is a fibrotic cutaneous disease with few effective therapies. Lycorine is a drug with pro-apoptotic ability and anti-fibrosis potential.
Yunxian Dong +5 more
doaj +1 more source
Poultry Science, 2021 : Duck tembusu virus (DTMUV) was firstly identified in 2010 in China; since then, it has caused enormous economic loss to breeding industry. Great efforts have been made to develop drugs and vaccines against DTMUV.
Xuan Lv +11 more
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Pharmacological Research, 2023 Lycorine, an isoquinoline alkaloid can exhibit significant anti-cancer effects. The present study was conducted to illustrate the underlying mechanisms of action of lycorine on breast carcinoma under in vitro and in vivo settings Tandem Mass Tag assay ...
Yanfang Sun +7 more
doaj +1 more source