Uncover the anticancer potential of lycorine [PDF]
Chinese MedicineBackground Natural products have a long history in drug discovery. Lycorine is an alkaloid derived from Amaryllidaceae plants, demonstrating significant pharmacological potential.
Yan-Ming Zhang +7 more
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Exploring the safety of lycorine in the central nervous system and its impact on pain-like behaviors in mice [PDF]
Scientific ReportsAlkaloid analgesics have been associated with adverse effects on the central nervous system (CNS). Therefore, it is crucial to characterize the effects of alkaloid analgesics.
Hasriadi Hasriadi +4 more
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HPLC - DAD Analysis of Lycorine in Amaryllidaceae Species [PDF]
Natural Product Communications, 2010 Lycorine, the most frequent alkaloid found in Amaryllidaceae plants, has been proven to have various biological activities. Therefore, it is important to quantify this compound in Amaryllidacaeae species.
Gulen Irem Kaya +4 more
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Lycorine inhibits the proliferation of acute myeloid leukemia cells by upregulating the expression of THBS1 [PDF]
Annals of HematologyTo clarify the biological roles of the putative target thrombospondin-1 (THBS1) and the impact of the traditional Chinese medicine monomer Lycorine on acute myeloid leukemia (AML) cells. The AML cell lines HL-60 and THP-1 were used in vitro to assess the
Lunbi Wu +9 more
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Lycorine ameliorates liver steatosis, oxidative stress, ferroptosis and intestinal homeostasis imbalance in MASLD mice [PDF]
Molecular MedicineBackground Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease worldwide and few drugs are available for its treatment.
Ziwen Wang +9 more
doaj +2 more sources
Amaryllidaceae Alkaloids and Phenolic Acids Identification in Leucojum aestivum L. Plant Cultures Exposed to Different Temperature Conditions [PDF]
MoleculesAmaryllidaceae alkaloids are of notable pharmacological relevance. For instance, galanthamine is used in the treatment of Alzheimer’s disease, while other alkaloids (lycorine, crinine, etc.) derived from Amaryllidaceae plants are also of great interest ...
Agata Ptak +7 more
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Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation
Molecules, 2014 Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities.
Lu-Qing Shang, Zheng Yin
exaly +3 more sources
NMR Metabolomic Profiling of Differentiated SH-SY5Y Neuronal Cells: Amyloid-β Toxicity and Protective Effects of Galantamine and Lycorine [PDF]
CellsAlzheimer’s disease (AD) is a multifactorial neurodegenerative disorder characterized by metabolic dysregulation, oxidative stress, amyloid-β (Aβ) aggregation, metal dyshomeostasis, and mitochondrial dysfunction.
Arian Kola +5 more
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In Vitro Inhibition of Alphaviruses by Lycorine [PDF]
Virologica Sinica, 2021 Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. As an emerging virus, CHIKV imposes a threat to public health. Currently, there are no vaccines or antivirals available for the prevention of CHIKV infection. Lycorine, an alkaloid from Amaryllidaceae plants, has antiviral activity against a number of viruses such as coronavirus, flavivirus and ...
Na Li +8 more
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Lycorine Inhibits Hypertrophic Scar Formation by Inducing ROS-Mediated Apoptosis
Frontiers in Bioengineering and Biotechnology, 2022 Background: Hypertrophic scar (HS) is a fibrotic cutaneous disease with few effective therapies. Lycorine is a drug with pro-apoptotic ability and anti-fibrosis potential.
Yunxian Dong +5 more
doaj +1 more source