Results 21 to 30 of about 3,343 (218)
Tandem mass tag-based quantitative proteomic analysis of lycorine treatment in highly pathogenic avian influenza H5N1 virus infection [PDF]
PeerJ, 2019 Highly pathogenic H5N1 influenza viruses (HPAIV) cause rapid systemic illness and death in susceptible animals, leading to a disease with high morbidity and mortality rates. Although vaccines and drugs are the best solution to prevent this threat, a more
Li Yang +8 more
doaj +2 more sources
Relevant and selective activity of Pancratium illyricum L. against Candida albicans clinical isolates: a combined effect on yeast growth and virulence [PDF]
, 2014 BACKGROUND: Alkaloids present in plants of the Amaryllidaceae family are secondary metabolites of high biological interest, possessing a wide range of pharmacological activities. In the search for new plant-derived compounds with antimicrobial activities,
Antognoni, F +5 more
core +1 more source
Two new alkaloids from Narcissus serotinus L. [PDF]
, 2010 The Amaryllidaceae family is well known for the presence of an exclusive group of alkaloids with a wide range of biological activities. Narcissus serotinus L.
Bastida Armengol, Jaume +6 more
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Effect of lycorine on the structure and function of hepatoma cell membrane in vitro and in vivo
Biotechnology & Biotechnological Equipment, 2020 Lycorine is an isoquinoline alkaloid in Amaryllidaceae with antitumor, antibacterial, antiviral, diuretic and cardiovascular effects. This study explored the antitumor mechanism of lycorine in vitro and in vivo by focusing on its effects on tumor cell ...
Guosong Xin +8 more
doaj +1 more source
Lycorine: a eukaryotic termination inhibitor?
Journal of Biological Chemistry, 1986 The effect of the alkaloid lycorine on viral protein synthesis was studied in poliovirus-infected HeLa cells. The incorporation of [3H]leucine was inhibited by lycorine in a dose-dependent way, although lycorine never completely abolished translation. Using polyacrylamide gel electrophoresis, the viral proteins were identified as derived from the P1 (5'
Boeye, Albert +3 more
openaire +4 more sources
Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition
Cancer Cell International, 2012 Background Lycorine, a natural alkaloid extracted from Amaryllidaceae, has shown various pharmacological effects. Recent studies have focused on the potential antitumor activity of lycorine. In our previous study, we found that lycorine decrease the cell
Li Lv +8 more
doaj +1 more source
ERK Inhibition Promotes Engraftment of Allografts by Reprogramming T‐Cell Metabolism
Advanced Science, 2023 Extracellular regulated protein kinases (ERK) signaling is a master regulator of cell behavior, life, and fate. Although ERK pathway is shown to be involved in T‐cell activation, little is known about its role in the development of allograft rejection ...
Xiaosheng Tan +15 more
doaj +1 more source
Horticulturae, 2023 Lycorine is an important Amaryllidaceae alkaloid showing anti-cancerous activity on numerous cell lines; and it also demonstrates antiviral activity against several viruses including SARS-CoV-2 responsible for COVID-19.
Rukaya Syeed +8 more
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Image Guided Biodistribution of Drugs and Drug Delivery [PDF]
, 2012 Image guided technique is playing an increasingly important role in the investigation of the biodistribution and pharmacokinetics of drugs or drug delivery systems.
Ding, Hong, Wu, Fang
core +1 more source
Frontiers in Pharmacology, 2019 Lycorine, a naturally occurring compound extracted from the Amaryllidaceae plant family, has been reported to exhibit antitumor activity in various cancer cell types.
Wu-yi Liu +10 more
doaj +1 more source