Results 21 to 30 of about 2,205 (198)

Lycorine attenuated proliferation and induced apoptosis on imatinib-resistant K562 cell by inhibiting autophagy

Discover Oncology
Background Tyrosine kinase inhibitor (TKI) resistance is a significant factor exacerbating the burden on chronic myeloid leukemia (CML) patients and impacting clinical efficacy.
Jun Bai, Zuxi Feng, Yaqiong Chen, Yanhong Li, Liansheng Zhang, Lijuan Li   +5 more
doaj   +2 more sources

Characterization of the SARS-CoV-2 Mutation Pattern Generated In Vitro by the Antiviral Action of Lycorine

COVID
SARS-CoV-2 persists worldwide, driving the demand for effective antivirals that inhibit replication and limit the emergence of resistant variants.
Silvina Soledad Maidana, Sonia Alejandra Romera, Ana Marandino, Rocío Lucia Tau, Juan Mauel Shammas, Yanina Panzera, Ruben Pérez   +6 more
doaj   +2 more sources

Comparative Analysis of Lycorine in Wild Plant and Callus Culture Samples of Hymenocallis littoralis by HPLC-UV Method [PDF]

The Scientific World Journal, 2014
The Hymenocallis littoralis, an ornamental and medicinal plant, had been traditionally used for wound healing. In the present study, an analytical method using HPLC with ultraviolet detection was developed for the quantification of lycorine in the ...
Sreeramanan Subramaniam, Jeevandran Sundarasekar, Geethaa Sahgal, Vikneswaran Murugaiyah   +3 more
doaj   +2 more sources

Application of HPLC-DAD for the quantification of Lycorine in Galanthus elwesii Hook

Brazilian Journal of Pharmaceutical Sciences, 2017
In the present study, a reversed-phase high-performance liquid chromatographic method has been used for the quantitative determination of lycorine in the aerial parts and bulbs of G. elwesii Hook.
Ahmet Emir, Ceren Emir, Buket Bozkurt, Mustafa Ali Onur, Nehir Unver Somer, Gulen Irem Kaya   +5 more
doaj   +2 more sources

Study on apoptosis effect of human breast cancer cell MCF-7 induced by lycorine hydrochloride via death receptor pathway

Saudi Pharmaceutical Journal, 2017
As research was conducted on the early apoptosis of human breast cancer cell MCF-7 caused by lycorine hydrochloride and the expression of the related apoptosis proteins.
Yubin Ji, Miao Yu, Zheng Qi, Di Cui, Guosong Xin, Bing Wang, Weiling Jia, Lin Chang   +7 more
doaj   +2 more sources

Lycorine protects motor neurons against TDP-43 proteinopathy-induced degeneration in cross-species models with amyotrophic lateral sclerosis

Pharmacological Research
Aggregation of TAR-DNA binding protein-43 (TDP-43) is a pathological feature present in nearly 97 % cases of amyotrophic lateral sclerosis (ALS), making it an attractive target for pathogenic studies and drug screening.
Jing Wen, Yunhao Li, Yanzhu Qin, Lingli Yan, Ke Zhang, Ang Li, Ziying Wang, Feng Yu, Jianheng Lai, Wei Yang, Yong U. Liu, Dajiang Qin, Huanxing Su   +12 more
doaj   +2 more sources

Quantititative Determination of Lycorine and Galanthamine in and by HPLC-DAD

Natural Product Communications, 2014
Lycorine and galanthamine have various biological activities. A reliable HPLC method coupled with DAD detection was developed and validated for the determination of galanthamine and lycorine in Galanthus trojanus and G. cilicicus. A simple method for the
Gulen Irem Kaya, Derya Cicek Polat, Buket Sarikaya, Mustafa Ali Onur, Nehir Unver Somer   +4 more
doaj   +2 more sources

Lycorine Derivative Inhibits SARS-CoV-2 Replication by Reducing -1 Programmed Ribosomal Frameshifting via Targeting ZAP. [PDF]

MedComm (2020)
The present study evaluated the antiviral potential of various lycorine derivatives and identified compound 7 as a promising candidate. Compound 7 demonstrated strong antiviral efficacy against both the original SARS‐CoV‐2 and its variants in vitro and in vivo.
Du T, Liu R, Zhang X, Shen L, Tang C, Wang J, Cheng Y, Yu W, Yin B, Lu S, Pan X, Peng X.   +11 more
europepmc   +2 more sources

Systematic Proteomic Characterization of EV-A71-Infected Mice Identifies Dynamic Molecular Changes and Therapeutic Targets. [PDF]

MedComm (2020)
Time‐resolved multi‐omics of EV‐A71‐infected BALB/c mice uncovered dynamic host responses, revealing rapid neutrophil extracellular traps (NETs) activation as a key event. Screened drugs (kinase inhibitors) suppressed viral replication in vitro and in vivo, suggesting the promise of targeting host phosphorylation networks as a viable antiviral strategy.
Peng W, Wang Q, Zhao B, Zhang L, Wu J, Wei X, Rong N, Wang Z, Liu K, Liu J, Yang J, Liu J.   +11 more
europepmc   +2 more sources

Correction to "Lycorine Derivative Inhibits SARS-CoV-2 Replication by Reducing -1 Programmed Ribosomal Frameshifting via Targeting ZAP". [PDF]

MedComm (2020)
MedComm, Volume 7, Issue 6, June 2026.
europepmc   +2 more sources