Results 41 to 50 of about 2,205 (198)
Frontiers in Pharmacology, 2019 Lycorine, a naturally occurring compound extracted from the Amaryllidaceae plant family, has been reported to exhibit antitumor activity in various cancer cell types.
Wu-yi Liu +10 more
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Kaohsiung Journal of Medical Sciences, 2023 Much is known about the significance of lycorine, a natural alkaloid, in combating various types of cancer, including breast cancer (BC), but whether it participates in regulating tamoxifen (TAM) resistance and its underlying mechanism remain to be ...
Jing Zhai, Jun‐Feng Jiang, Lei Shi
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Apoptosis Induction of Lycorine on Lung Cancer NCI-H460 Cells and Related Mechanism
Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the effect of lycorine on the proliferation inhibition and apoptosis induction in human lung cancer NCI-H460 cells, and to explore the anti-tumor mechanism of lycorine.
LI Juwei, YANG Yang
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Lycorine Downregulates HMGB1 to Inhibit Autophagy and Enhances Bortezomib Activity in Multiple Myeloma [PDF]
, 2016 Multiple myeloma (MM) is largely incurable and drug-resistant. Novel therapeutic approaches such as inhibiting autophagy or rational drug combinations are aimed to overcome this issue.
Luo, Yuhao +12 more
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The First Asymmetric Total Syntheses of (+)-Lycorine and (+)-1-Deoxylycorine
, 2016 The first asymmetric total syntheses of (+)-1-deoxylycorine (2a) and (+)-lycorine (2b), the unnatural enantiomer of lycorine (1), are described. Construction of lactam 12, a key intermediate in the synthesis of both 2a and 2b, began by Birch reduction ...
Mark A. Holoboski (2996685) +2 more
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Biological Activities of Snowdrop (Galanthus spp., Family Amaryllidaceae)
Frontiers in Pharmacology, 2021 Snowdrop is an iconic early spring flowering plant of the genus Galanthus (Amaryllidaceae). Galanthus species (Galanthus spp.) are economically important plants as ornaments. Galanthus spp has gained significance scientific and commercial interest due to
Chee Kei Kong +13 more
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Bangladesh Journal of Pharmacology, 2018 This study was aimed to determine the effects of lycorine, a toxic crystalline alkaloid, on MDA-MB-231 breast cancer cells proliferation, migration and invasion, and to investigate the mechanism involved.
Xia-Liang Chen
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In search of a cytostatic agent derived from the alkaloid lycorine: Synthesis and growth inhibitory properties of lycorine derivatives [PDF]
Bioorganic & Medicinal Chemistry, 2011 As a continuation of our studies aimed at the development of a new cytostatic agent derived from an Amaryllidaceae alkaloid lycorine, we synthesized 32 analogues of this natural product. This set of synthetic analogues included compounds incorporating selective derivatization of the C1 versus C2 hydroxyl groups, aromatized ring C, lactamized N6 ...
Evdokimov N. M. +10 more
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Lycorine Derivatives Against Trichomonas vaginalis [PDF]
Chemical Biology & Drug Design, 2012 Six lycorine derivatives were prepared, characterized, and evaluated for their in vitro anti‐Trichomonas vaginalis activity. Compounds bearing an acetyl (2), lauroyl (3), benzoyl (4 and 5), and p‐nitrobenzoyl (6 and 7) groups were synthesized. The best activity was achieved with lycorine esterified at C‐2 position with lauroyl group.
Raquel B, Giordani +6 more
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Total Synthesis of (−)-Lycorine and (−)-2-epi-Lycorine by Asymmetric Conjugate Addition Cascade
, 2016 Total syntheses of (−)-lycorine and (−)-2-epi-lycorine were accomplished using chiral ligand-controlled asymmetric cascade conjugate addition methodology, which enables the formation of two C−C bonds and three stereogenic centers in one pot to give ...
Ken-ichi Yamada (714528) +4 more
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