Cytotoxicity and Antioxidant Activity of Zingiber Officinale and 6-Gingerol on HepG2 Cells [PDF]
, 2008 The present study was designed to compare the effects of ethanolic extract of ginger (Zingiber officinale) and its phenolic component [6]-Gingerol on viability, antiproliferation and apoptotic levels of human hepatoma cell lines (HepG2) and its ...
Hanif, H. (Harliansyah) +3 more
core +2 more sources
Lycorine Carbamate Derivatives for Reversing P-Glycoprotein-Mediated Multidrug Resistance in Human Colon Adenocarcinoma Cells [PDF]
, 2023 Multidrug resistance (MDR) is a major challenge in cancer chemotherapy. Aiming at generating a small library of anticancer compounds for overcoming MDR, lycorine (1), a major Amaryllidaceae alkaloid isolated from Pancratium maritimum, was derivatized ...
Ferreira Maria-José U. +3 more
core +1 more source
A Biomimetic Total Synthesis of Clivonine
, 2011 The first chapter of this thesis discusses the biomimetic total synthesis of clivonine. Clivonine is a member of the Amaryllidaceae family of alkaloids and was isolated from the plant Clivia miniata Regel by Wildman in 1956.
Paddock, Victoria L. +1 more
core +1 more source
Natural AChE inhibitors from plants and their contribution to Alzheimer´s disease therapy [PDF]
, 2013 As acetylcholinesterase (AChE) inhibitors are an important therapeutic strategy in Alzheimer's disease, efforts are being made in search of new molecules with anti-AChE activity.
Alza, Natalia Paola +4 more
core +2 more sources
Chemistry Central Journal, 2012 Background Alzheimer’s disease (AD) is a neurologically degenerative disorder that affects more than 20 million people worldwide. The selective butyrylcholinesterase (BChE) inhibitors and bivalent cholinesterase (ChE) inhibitors represent new treatments ...
Wang Yue-Hu +4 more
doaj +1 more source
ChemistryEurope, Volume 4, Issue 4, April 2026.We report a biosynthesis‐inspired ring distortion approach that involves oxidative ring cleavage, ring rearrangement, and ring expansion reactions from a diverse collection of indole alkaloids and derivatives. This chemical synthesis approach led to the synthesis of >25 distinct chemotypes from 14 indole alkaloids.
Derek A. Leas +7 more
wiley +1 more source
Study of Molecular Docking of Alkaloid Derivative Compounds from Stem Karamunting (Rhodomyrtus tomentosa) Against α-glucosidase Enzymes [PDF]
, 2021 Karamunting plant (Rhodomyrtus tomentosa) is a traditional medicinal plant. The leaves, roots, stems, and fruits of Karamunting have been identified, and their biological activities are antioxidants, antibacterial, antidiabetic, anti-inflammatory, and ...
mulyati, Budi, Seulina Panjaitan, Riong
core +2 more sources
Discovery of anthelmintic drug targets and drugs using chokepoints in nematode metabolic pathways [PDF]
, 2013 Parasitic roundworm infections plague more than 2 billion people (1/3 of humanity) and cause drastic losses in crops and livestock. New anthelmintic drugs are urgently needed as new drug resistance and environmental concerns arise. A "chokepoint reaction"
Abubucker, Sahar +8 more
core +4 more sources
Plants, 2023 This study investigated the protective effects of exogenous ascorbic acid (AsA, 0.5 mmol·L−1) treatment on salt-induced photosystem inhibition in tomato seedlings under salt stress (NaCl, 100 mmol·L−1) conditions with and without the AsA inhibitor ...
Xianjun Chen +9 more
doaj +1 more source
Chemical Characterization and Cytotoxic and Antioxidant Activity Evaluation of the Ethanol Extract from the Bulbs of Pancratium maritimun Collected in Sicily [PDF]
, 2023 P. maritimum L., belonging to the Amaryllidaceae family, is a species that grows on beaches and coastal sand dunes mainly on both sides of the Mediterranean Sea and Black Sea, the Middle East, and up to the Caucasus region.
Bruno, Maurizio +6 more
core +2 more sources