Results 41 to 50 of about 24,249 (204)

Integrins and Their Extracellular Matrix Ligands in Lymphangiogenesis and Lymph Node Metastasis

International Journal of Cell Biology, 2012
In the 1970s, the late Judah Folkman postulated that tumors grow proportionately to their blood supply and that tumor angiogenesis removed this limitation promoting growth and metastasis. Work over the past 40 years, varying from molecular examination to
Jie Chen, J. Steven Alexander, A. Wayne Orr   +2 more
doaj   +1 more source

Lymphangiogenesis Guidance Mechanisms and Therapeutic Implications in Pathological States of the Cornea

Cells, 2023
Corneal lymphangiogenesis is one component of the neovascularization observed in several inflammatory pathologies of the cornea including dry eye disease and corneal graft rejection.
Mehul Patnam, Sunil R. Dommaraju, Faisal Masood, Paula Herbst, Jin-Hong Chang, Wen-Yang Hu, Mark I. Rosenblatt, Dimitri T. Azar   +7 more
doaj   +1 more source

Increased lymphangiogenesis in joints of mice with inflammatory arthritis [PDF]

, 2007
Angiogenesis is involved in the pathogenesis of inflammatory arthritis, but little is known about the role of lymphangiogenesis in this setting. Here, we examined whether tumor necrosis factor (TNF) stimulates osteoclast precursors (OCPs) to produce the ...
Schwarz, Edward M, Zhang, Qian, Boyce, Brendan F, Yan Lu, Xing, Lianping, Lianping Xing, Guo, Ruolin, Proulx, Steven T, Yao, Zhenqiang, Steven T Proulx, Zhenqiang Yao, Brendan F Boyce, Lu, Yan, Edward M Schwarz, Qian Zhang, Ruolin Guo   +15 more
core   +2 more sources

Negative regulation of lymphangiogenesis by Tenascin-C delays the resolution of inflammation

iScience
Summary: Lymphatic vessels are required for the clearance of excess fluid and immune cells from inflamed tissue, making the regulation of lymphangiogenesis an important area of research.
Daisuke Katoh, Yoshiyuki Senga, Kento Mizutani, Kazuaki Maruyama, Daishi Yamakawa, Tadashi Yamamuro, Michiaki Hiroe, Keiichi Yamanaka, Akihiro Sudo, Naoyuki Katayama, Toshimichi Yoshida, Kyoko Imanaka-Yoshida   +11 more
doaj   +1 more source

Effects of inhibition of lymphangiogenesis by the vascular endothelial growth factor receptor 3 (VEGFR-3) inhibitor, MAZ51 on full thickness wounds in mice

Veins and Lymphatics, 2021
We herein used MAZ51 to inhibit lymphangiogenesis and aimed to clarify the effect of inhibition of lymphangiogenesis on wound healing. BALB/c male mice were divided into two groups: the control group which was injected the dimethyl sulfoxide (DMSO), the ...
Kana Takada, Yukari Nakajima, Tamae Urai, Kanae Mukai, Kimi Asano, Mayumi Okuwa, Junko Sugama, Toshio Nakatani   +7 more
doaj   +1 more source

Lysyl Oxidase-Like Protein 2 Promotes Tumor Lymphangiogenesis and Lymph Node Metastasis in Breast Cancer

Neoplasia: An International Journal for Oncology Research, 2019
Tumor lymphangiogenesis has been previously documented to predict regional lymph node metastasis and promote the spread to distant organs. However, the underlying mechanism initiating tumor lymphangiogenesis remains unclear.
Chunying Wang, Siran Xu, Yang Tian, Anji Ju, Qiaoyun Hou, Jie Liu, Yan Fu, Yongzhang Luo   +7 more
doaj   +1 more source

Lymphangiogenesis and Lesion Heterogeneity in Interstitial Lung Diseases

Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, 2015
The lymphatic system has several physiological roles, including fluid homeostasis and the activation of adaptive immunity by fluid drainage and cell transport. Lymphangiogenesis occurs in adult tissues during various pathologic conditions.
Masahiro Yamashita
doaj   +1 more source

Lymphangiogenesis induced by vascular endothelial growth factor receptor 1 signaling contributes to the progression of endometriosis in mice

Journal of Pharmacological Sciences, 2020
Lymphangiogenesis is related to the growth of endometriosis. Here, we examined whether vascular endothelial growth factor (VEGF) receptor 1 (VEGFR1) signaling plays a role in lymphangiogenesis during endometriosis.
Kyoko Hattori, Yoshiya Ito, Masako Honda, Kazuki Sekiguchi, Kanako Hosono, Masabumi Shibuya, Nobuya Unno, Masataka Majima   +7 more
doaj   +1 more source

CEACAM1 increased the lymphangiogenesis through miR-423-5p and NF- kB in Non-Small Cell Lung Cancer

Biochemistry and Biophysics Reports
Background: Lung cancer causes significant mortality, with invasion and metastasis being the main features that cause most cancer deaths. Lymph node metastasis is the primary metastatic route in non-small cell carcinoma (NSCLC) and influences the staging
Jie Yu, Wenke Cai, Tao Zhou, Bo Men, Shunqiong Chen, Dong Tu, Wei Guo, Jicui Wang, Feipeng Zhao, Yan Wang   +9 more
doaj   +1 more source

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source