Results 31 to 40 of about 26,475 (231)
The Role of Periostin in Angiogenesis and Lymphangiogenesis in Tumors
Cancers, 2022 Simple Summary Cancers are common diseases that affect people of all ages worldwide. For this reason, continuous attempts are being made to improve current therapeutic options.
Adrian Wasik +4 more
semanticscholar +1 more source
Computational and Mathematical Methods in Medicine, 2003 While much effort is given to the modelling of tumour angiogenesis, little attention is paid to lymphangiogenesis and its potential role in tumour progression and metastasis. This is due at least in part to the controversy that surrounds tumour lymphangiogenesis—opinion is divided as to whether tumours actively promote the development of lymph channels
Catherine R. Tait, Pamela F. Jones
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PEDF inhibits lymphatic metastasis of nasopharyngeal carcinoma as a new lymphangiogenesis inhibitor
Cell Death and Disease, 2021 Nasopharyngeal carcinoma (NPC) is one of the most malignant tumors in southern China and Asia, and lymph node metastasis is an important cause for treatment failure.
Chuanghua Luo +13 more
doaj +1 more source
Role of Extracellular Vesicles on Cancer Lymphangiogenesis and Lymph Node Metastasis
Frontiers in Oncology, 2021 Lymph node metastasis (LNM) of tumors is an established indicator of poor prognosis in patients. Tumor-associated lymphangiogenesis is a key step in LNM and has gained much attention. However, currently, there is no anti-tumor lymphangiogenesis drug used
Linlin Wang, Ling Li, Guiquan Zhu
doaj +1 more source
Journal of Clinical Investigation, 2022 Lymph node (LN) metastasis occurs frequently in pancreatic ductal adenocarcinoma (PDAC) and predicts poor prognosis for patients. The KRASG12D mutation confers an aggressive PDAC phenotype that is susceptible to lymphatic dissemination.
Yuming Luo +11 more
semanticscholar +1 more source
Lymphangiogenesis and tumor metastasis
Thrombosis and Haemostasis, 2003 SummaryIn several human cancers, increased expression in primary tumors of vascular endothelial growth factor-C (VEGF-C) is correlated with regional lymph node metastasis. Studies using transgenic mice overexpressing VEGF-C, or xenotransplantation of VEGF-C-expressing tumor cells into immunodeficient mice, have demonstrated a role for VEGF-C in tumor ...
Nisato RE, Tille JC, Pepper MS
openaire +7 more sources
Signaling of Prostaglandin E Receptors, EP3 and EP4 Facilitates Wound Healing and Lymphangiogenesis with Enhanced Recruitment of M2 Macrophages in Mice. [PDF]
PLoS ONE, 2016 Lymphangiogenesis plays an important role in homeostasis, metabolism, and immunity, and also occurs during wound-healing. Here, we examined the roles of prostaglandin E2 (PGE2) receptor (EP) signaling in enhancement of lymphangiogenesis in wound healing ...
Kanako Hosono +4 more
doaj +1 more source
Lymphangiogenesis contributes to exercise-induced physiological cardiac growth
Journal of Sport and Health Science, 2022 Highlights • Cardiac lymphangiogenesis is required for exercise-induced physiological cardiac growth by VEGFR3 activation, while exercise-induced myocardial hypertrophy and increased proliferation marker in cardiomyocytes are altered by VEGFR3 inhibition.
Yihua Bei +10 more
semanticscholar +1 more source
Lymphangiogenesis is required for pancreatic islet inflammation and diabetes. [PDF]
PLoS ONE, 2011 Lymphangiogenesis is a common phenomenon observed during inflammation and engraftment of transplants, but its precise role in the immune response and underlying mechanisms of regulation remain poorly defined. Here we showed that in response to injury and
Na Yin +6 more
doaj +1 more source
Journal of Translational Medicine, 2020 Background The tumor microenvironment (TME) is a critical player in tumor progression, metastasis and therapy outcomes. Tumor-associated macrophages (TAMs) are a well-recognized core element of the TME and generally characterized as M2-like macrophages ...
I. Hwang +9 more
semanticscholar +1 more source