Results 11 to 20 of about 24,249 (204)

Does plasminogen activator inhibitor-1 drive lymphangiogenesis? [PDF]

PLoS ONE, 2010
The purpose of this study is to explore the function of plasminogen activator inhibitor-1 (PAI-1) during pathological lymphangiogenesis. PAI-1, the main physiological inhibitor of plasminogen activators is involved in pathological angiogenesis at least ...
Françoise Bruyère, Laurence Melen-Lamalle, Silvia Blacher, Benoît Detry, Anne Masset, Julie Lecomte, Vincent Lambert, Catherine Maillard, Gunilla Høyer-Hansen, Leif R Lund, Jean-Michel Foidart, Agnès Noël   +11 more
doaj   +3 more sources

Lymphangiogenesis in gastric cancer: function and mechanism

European Journal of Medical Research, 2023
Increased lymphangiogenesis and lymph node (LN) metastasis are thought to be important steps in cancer metastasis, and are associated with patient's poor prognosis.
Pengpeng Liu, Ping’an Ding, Chenyu Sun, Shuya Chen, Scott Lowe, Lingjiao Meng, Qun Zhao   +6 more
doaj   +2 more sources

Lymphangiogenesis and tumor metastasis

Thrombosis and Haemostasis, 2003
SummaryIn several human cancers, increased expression in primary tumors of vascular endothelial growth factor-C (VEGF-C) is correlated with regional lymph node metastasis. Studies using transgenic mice overexpressing VEGF-C, or xenotransplantation of VEGF-C-expressing tumor cells into immunodeficient mice, have demonstrated a role for VEGF-C in tumor ...
Nisato RE, Tille JC, Pepper MS
core   +8 more sources

A zebrafish model of inflammatory lymphangiogenesis [PDF]

Biology Open, 2015
Inflammatory bowel disease (IBD) is a disabling chronic inflammatory disease of the gastrointestinal tract. IBD patients have increased intestinal lymphatic vessel density and recent studies have shown that this may contribute to the resolution of IBD ...
Kazuhide S. Okuda, June Pauline Misa, Stefan H. Oehlers, Christopher J. Hall, Felix Ellett, Sultan Alasmari, Graham J. Lieschke, Kathryn E. Crosier, Philip S. Crosier, Jonathan W. Astin   +9 more
doaj   +4 more sources

Lymphangiogenesis and cancer metastasis

Frontiers in Bioscience, 2011
Lymphangiogenesis remains a fascinating biological process that plays a crucial role in both normal tissue development and several lymphatic diseases. The last few years have witnessed a rapid progression in understanding the development and regulation of the lymphatic system which provided insight on several pathological processes including cancer ...
Mahir A A, Al-Rawi, Wen G, Jiang
openaire   +3 more sources

Role of lymphangiogenesis in lung cancer. [PDF]

Folia Histochemica et Cytobiologica, 2010
Lung cancer represents one of the most frequent causes of death due to neoplastic disease in Poland and around the world. The high mortality which accompany neoplastic diseases used to be ascribed mainly to dissemination of cancerous cells.
Renata Jankowska, Piotr Dziegiel, Bozena Weryńska   +2 more
doaj   +4 more sources

Ginsenoside Rg1 Ameliorates LPS-Induced Sepsis-Associated Lung Injury in Mice via VEGFC/D-VEGFR3 Signaling-Mediated Lymphangiogenesis and Lymphatic Remodeling. [PDF]

Kaohsiung J Med Sci
ABSTRACT Sepsis‐induced acute lung injury (ALI) remains challenging to treat, with conventional anti‐inflammatory therapies offering limited efficacy. The lymphatic system is crucial for removing edema and inflammatory mediators, and its impairment can exacerbate lung injury.
Wang H, Hu L, Zhang CP, Qi WJ, Song YG.
europepmc   +2 more sources

Identification of Gene Expression Differences between Lymphangiogenic and Non-Lymphangiogenic Non-Small Cell Lung Cancer Cell Lines. [PDF]

PLoS ONE, 2016
It is well established that lung tumors induce the formation of lymphatic vessels. However, the molecular mechanisms controlling tumor lymphangiogenesis in lung cancer have not been fully delineated. In the present study, we identify a panel of non-small
Erin Regan, Robert C Sibley, Bercin Kutluk Cenik, Asitha Silva, Luc Girard, John D Minna, Michael T Dellinger   +6 more
doaj   +1 more source

Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function

Cells, 2022
The lymphatic system is pivotal for immunosurveillance and the maintenance of tissue homeostasis. Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vessels, has both physiological and pathological roles.
Bhupesh Singla, Ravi Varma Aithabathula, Sonia Kiran, Shweta Kapil, Santosh Kumar, Udai P. Singh   +5 more
doaj   +1 more source

Lymphangiogenesis in renal inflammation and transplantation [PDF]

, 2013
The lymphatic system plays an important role in both tissue homeostasis and inflammation. During the surgical procedure there is complete disruption of lymphatic drainage of the allograft kidney.
Vass, David George
core   +3 more sources