Results 11 to 20 of about 26,475 (231)

Integrins in angiogenesis and lymphangiogenesis [PDF]

Nature Reviews Cancer, 2008
Blood vessels promote tumour growth, and both blood and lymphatic vessels facilitate tumour metastasis by serving as conduits for the transport of tumour cells to new sites. Angiogenesis and lymphangiogenesis are regulated by integrins, which are members of a family of cell surface receptors whose ligands are extracellular matrix proteins and ...
Garmy-Susini B, Judith Varner, Varner Judith A   +2 more
exaly   +3 more sources

Hydroxysafflor yellow A regulates lymphangiogenesis and inflammation via the inhibition of PI3K on regulating AKT/mTOR and NF-κB pathway in macrophages to reduce atherosclerosis in ApoE-/- mice.

Phytomedicine, 2023
BACKGROUND Macrophage-mediated inflammatory infiltration and pathological lymphangiogenesis around atherosclerotic plaques are newly highlighted treatment targets of atherosclerosis. Although the effect of Hydroxysafflor yellow A(HSYA) on atherosclerosis
Xiaoteng Feng, Min Du, Sijin Li, Yifan Zhang, Jie Ding, Jiarou Wang, Yiru Wang, Ping Liu   +7 more
semanticscholar   +1 more source

Lymphatic Endothelial Markers and Tumor Lymphangiogenesis Assessment in Human Breast Cancer

Diagnostics, 2021
Metastasis via lymphatic vessels or blood vessels is the leading cause of death for breast cancer, and lymphangiogenesis and angiogenesis are critical prerequisites for the tumor invasion–metastasis cascade.
Jia-Mei Chen, Bo Luo, Ru Ma, Xi-Xi Luo, Yong-Shun Chen, Yan Li   +5 more
doaj   +1 more source

ALKBH5 activates FAK signaling through m6A demethylation in ITGB1 mRNA and enhances tumor-associated lymphangiogenesis and lymph node metastasis in ovarian cancer

Theranostics, 2023
Background: Lymph node (LN) metastasis is common in patients with epithelial ovarian cancer (EOC) and is associated with poor prognosis. Tumor-associated lymphangiogenesis is the first stage of LN metastasis.
Rui Sun, Lin Yuan, Yi Jiang, Y. Wan, Xiaolling Ma, Jing Yang, Guodong Sun, Shulin Zhou, Hui Wang, Jiangnan Qiu, Lin Zhang, Wenjun Cheng   +11 more
semanticscholar   +1 more source

High endogenous CCL2 expression promotes the aggressive phenotype of human inflammatory breast cancer

Nature Communications, 2021
Inflammatory breast cancer (IBC) is an aggressive form of breast cancer with a poor prognosis. Here the authors report the characterization of a human IBC cell line recapitulating the clinical and histopathological features of the human disease, and ...
Anita Rogic, Ila Pant, Luca Grumolato, Ruben Fernandez-Rodriguez, Andrew Edwards, Suvendu Das, Aaron Sun, Shen Yao, Rui Qiao, Shabnam Jaffer, Ravi Sachidanandam, Guray Akturk, Rosa Karlic, Mihaela Skobe, Stuart A. Aaronson   +14 more
doaj   +1 more source

FASN promotes lymph node metastasis in cervical cancer via cholesterol reprogramming and lymphangiogenesis

Cell Death and Disease, 2022
Cervical cancer (CC) patients with lymph node metastasis (LNM) have a poor prognosis. Clarification of the detailed mechanisms underlying LNM may provide potential clinical therapeutic targets for CC patients with LNM. However, the molecular mechanism of
Q. Du, Pan Liu, Chunyu Zhang, Tianyu Liu, Wei Wang, C. Shang, Jieyu Wu, Y. Liao, Yili Chen, Jia-ming Huang, Hao Tan, Yun-he Zhao, M. Xia, Junxiu Liu, S. Yao   +14 more
semanticscholar   +1 more source

Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism.

Nature Cancer, 2021
Secreted extracellular vesicles (EVs) influence the tumor microenvironment and promote distal metastasis. Here we analyzed the involvement of melanoma-secreted EVs in lymph node pre-metastatic niche formation in murine models.
S. García-Silva, A. Benito‐Martin, Laura Nogués, Alberto Hernández-Barranco, Marina S. Mazariegos, Vanesa Santos, M. Hergueta-Redondo, P. Ximénez-Embún, Raghu P. Kataru, Ana Amor López, C. Merino, S. Sánchez‐Redondo, Osvaldo Graña-Castro, Irina R Matei, J. A. Nicolás-Ávila, R. Torres-Ruiz, S. Rodríguez-Perales, Lola Martínez, Manuel Pérez-Martínez, Gadea Mata, A. Szumera-Ciećkiewicz, I. Kalinowska, A. Saltari, J. Martinez-Gomez, S. Hogan, H. Saragovi, Sagrario Ortega, C. García-Martín, J. Boskovic, M. Levesque, P. Rutkowski, A. Hidalgo, J. Muñoz, D. Megías, B. Mehrara, D. Lyden, H. Peinado   +36 more
semanticscholar   +1 more source

Lymphangiogenesis and Cancer [PDF]

Genes & Cancer, 2011
Historically, lymphatic vessels were considered passive participants in tumor metastasis by simply providing channels for tumor cells to transit to draining lymph nodes. The discovery of several key lymphatic-specific molecular markers and an increased availability of in vitro and in vivo experimental systems to study lymphatic biology have however ...
Christiansen A, Detmar M
openaire   +3 more sources

Activation of Dll4/Notch Signaling and Hypoxia-Inducible Factor-1 Alpha Facilitates Lymphangiogenesis in Lacrimal Glands in Dry Eye. [PDF]

PLoS ONE, 2016
By using hypoxia-inducible factor-1 alpha conditional knockout (HIF-1α CKO) mice and a dry eye (DE) mouse model, we aimed to determine the role played by delta-like ligand 4 (Dll4)/Notch signaling and HIF-1α in the lymphangiogenesis of lacrimal glands ...
Ji Hwan Min, Chul Hee Lee, Yong Woo Ji, Areum Yeo, Hyemi Noh, Insil Song, Eung Kweon Kim, Hyung Keun Lee   +7 more
doaj   +1 more source

CD47 activation by thrombospondin-1 in lymphatic endothelial cells suppresses lymphangiogenesis and promotes atherosclerosis

Arteriosclerosis, Thrombosis and Vascular Biology, 2023
Background: TSP1 (thrombospondin-1)—a well-known angiogenesis inhibitor—mediates differential effects via interacting with cell surface receptors including CD36 (cluster of differentiation) and CD47.
Bhupesh Singla, Ravi Varma Aithbathula, N. Pervaiz, Ishita Kathuria, M. Swanson, F. Ekuban, WonMo Ahn, Frank Park, Maxwell A. Gyamfi, M. Cherian-Shaw, Udai P. Singh, Santosh Kumar   +11 more
semanticscholar   +1 more source