Results 21 to 30 of about 26,475 (231)

Lymphangiogenesis and Anti-lymphangiogenesis in Cutaneous Melanoma [PDF]

Anticancer Research, 2016
Cutaneous malignant melanoma is an aggressive tumor characterized by early lymph node metastasis and bad prognosis. Although the spread of tumor cells in the regional lymph nodes is very important in the staging, prognosis and therapeutic strategy of malignant melanoma, the mechanism(s) of initial lymphatic vessels invasion is are) not completely ...
Marius, Raica, Adriana-Andreea, Jitariu, Anca Maria, Cimpean   +2 more
openaire   +2 more sources

Identification of Gene Expression Differences between Lymphangiogenic and Non-Lymphangiogenic Non-Small Cell Lung Cancer Cell Lines. [PDF]

PLoS ONE, 2016
It is well established that lung tumors induce the formation of lymphatic vessels. However, the molecular mechanisms controlling tumor lymphangiogenesis in lung cancer have not been fully delineated. In the present study, we identify a panel of non-small
Erin Regan, Robert C Sibley, Bercin Kutluk Cenik, Asitha Silva, Luc Girard, John D Minna, Michael T Dellinger   +6 more
doaj   +1 more source

Downregulation of miR‐100‐5p in cancer‐associated fibroblast‐derived exosomes facilitates lymphangiogenesis in esophageal squamous cell carcinoma

Cancer Medicine, 2023
Esophageal squamous cell carcinoma (ESCC), an aggressive gastrointestinal tumor, often has high early lymphatic metastatic potential. Cancer‐associated fibroblasts (CAFs) are primary components in tumor microenvironment (TME), and the impact of CAFs and ...
Chao Chen, Chenbo Yang, Xiangyu Tian, Yinghao Liang, Shuaiyuan Wang, Xiaoqian Wang, Yuwei Shou, Hui Li, Qiankun Xiao, Jiao Shu, Miaomiao Sun, Kuisheng Chen   +11 more
semanticscholar   +1 more source

Breaking a Vicious Circle: Lymphangiogenesis as a New Therapeutic Target in Wound Healing

Biomedicines, 2023
The lymphatic system is of fundamental importance in maintaining a fluid balance in the body and tissue homeostasis; it drains protein-rich lymph from the interstitial space and facilitates the release of cells that mediate the immune response.
F. Renó, M. Sabbatini
semanticscholar   +1 more source

Promotion of Lymphangiogenesis by Targeted Delivery of VEGF-C Improves Diabetic Wound Healing

Cells, 2023
Chronic wounds represent a major therapeutic challenge. Lymphatic vessel function is impaired in chronic ulcers but the role of lymphangiogenesis in wound healing has remained unclear. We found that lymphatic vessels are largely absent from chronic human
L. Brunner, Yuliang He, N. Cousin, Jeannette Scholl, Livia K. Albin, B. Schmucki, S. Supersaxo, G. Restivo, J. Hafner, D. Neri, Sabine Werner, M. Detmar   +11 more
semanticscholar   +1 more source

Does plasminogen activator inhibitor-1 drive lymphangiogenesis? [PDF]

PLoS ONE, 2010
The purpose of this study is to explore the function of plasminogen activator inhibitor-1 (PAI-1) during pathological lymphangiogenesis. PAI-1, the main physiological inhibitor of plasminogen activators is involved in pathological angiogenesis at least ...
Françoise Bruyère, Laurence Melen-Lamalle, Silvia Blacher, Benoît Detry, Anne Masset, Julie Lecomte, Vincent Lambert, Catherine Maillard, Gunilla Høyer-Hansen, Leif R Lund, Jean-Michel Foidart, Agnès Noël   +11 more
doaj   +1 more source

Current Status of Lymphangiogenesis: Molecular Mechanism, Immune Tolerance, and Application Prospect

Cancers, 2023
Simple Summary Lymphatic vessels are low-pressure, blind-ended tubular structures essential in maintaining tissue fluid homeostasis, immune cell transport, and lipid transport. More and more evidence showed that lymphangiogenesis might be closely related
Hongyang Deng, Jiaxing Zhang, Fahong Wu, Feng-xian Wei, Wei Han, Xiao-dong Xu, Youcheng Zhang   +6 more
semanticscholar   +1 more source

MiR-155-5p-SOCS1/JAK1/STAT1 participates in hepatic lymphangiogenesis in liver fibrosis and cirrhosis by regulating M1 macrophage polarization

Human and Experimental Toxicology, 2023
Background The role and underlying mechanism of liver macrophages and their derived miR-155-5p in hepatic lymphangiogenesis in liver fibrosis remain unclear.
Jian Bi, J. Liu, Xiuli Chen, Na-Na Shi, Hao Wu, Haiying Tang, Jingwei Mao   +6 more
semanticscholar   +1 more source

Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

Journal of Clinical Investigation, 2022
Vascular endothelial growth factor C (VEGF-C) induces lymphangiogenesis via VEGF receptor 3 (VEGFR3), which is encoded by the most frequently mutated gene in human primary lymphedema. Angiopoietins (Angs) and their Tie receptors regulate lymphatic vessel
E. Korhonen, Aino Murtomäki, S. K. Jha, A. Anisimov, A. Pink, Yan Zhang, Simon Stritt, Inam Liaqat, L. Stanczuk, Laura Alderfer, Zhiliang Sun, Emmi Kapiainen, Abhishek Singh, Ibrahim Sultan, Anni Lantta, V. Leppänen, L. Eklund, Yulong He, H. Augustin, Kari Vaahtomeri, P. Saharinen, Taija Mäkinen, K. Alitalo   +22 more
semanticscholar   +1 more source

Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis

Nature Communications, 2022
Autophagy has vasculoprotective roles, but whether and how it regulates lymphatic endothelial cells (LEC) homeostasis and lymphangiogenesis is unknown.
O. Meçe, Diede Houbaert, M. Sassano, Tania Durré, H. Maes, Marco B. E. Schaaf, S. More, Maarten Ganne, Melissa García-Caballero, M. Borri, J. Verhoeven, M. Agrawal, Kathryn A Jacobs, G. Bergers, S. Blacher, B. Ghesquière, M. Dewerchin, Johan V. Swinnen, S. Vinckier, M. Soengas, P. Carmeliet, A. Noël, P. Agostinis   +22 more
semanticscholar   +1 more source