Results 21 to 30 of about 33,655 (235)

Lymphangiogenesis and tumor metastasis [PDF]

Thrombosis and Haemostasis, 2003
SummaryIn several human cancers, increased expression in primary tumors of vascular endothelial growth factor-C (VEGF-C) is correlated with regional lymph node metastasis. Studies using transgenic mice overexpressing VEGF-C, or xenotransplantation of VEGF-C-expressing tumor cells into immunodeficient mice, have demonstrated a role for VEGF-C in tumor ...
Riccardo E, Nisato, Jean-Christophe, Tille, Michael S, Pepper   +2 more
openaire   +5 more sources

Evolutionary Differences in the Vegf/Vegfr Code Reveal Organotypic Roles for the Endothelial Cell Receptor Kdr in Developmental Lymphangiogenesis

Cell Reports, 2019
Summary: Lymphatic vascular development establishes embryonic and adult tissue fluid balance and is integral in disease. In diverse vertebrate organs, lymphatic vessels display organotypic function and develop in an organ-specific manner. In all settings,
Adam J. Vogrin, Neil I. Bower, Menachem J. Gunzburg, Sally Roufail, Kazuhide S. Okuda, Scott Paterson, Stephen J. Headey, Steven A. Stacker, Benjamin M. Hogan, Marc G. Achen   +9 more
doaj   +1 more source

Local induction of lymphangiogenesis with engineered fibrin-binding VEGF-C promotes wound healing by increasing immune cell trafficking and matrix remodeling [PDF]

, 2017
Lymphangiogenesis occurs in inflammation and wound healing, yet its functional roles in these processes are not fully understood. Consequently, clinically relevant strategies for therapeutic lymphangiogenesis remain underdeveloped, particularly using ...
Achen, Baluk, Baluk, Baluk, Baluk, Beauvillain, Boardman, Briquez, Broggi, Card, Didier Foretay, Djonov, Ehrbar, Epstein, Esra Güç, Fonseca, Forster, Goldman, Goldman, Guc, Helm, Hoshida, Isaka, Issa, Janmey, Jeffrey A. Hubbell, Jeltsch, Johnson, Johnson, Joukov, Kilarski, Kilarski, Kilarski, Kilarski, Kilarski, Kim, Kukk, Lammermann, Lawrance, Lee, Lorentz, Lorentz, Lutolf, Manuel A. Fankhauser, Martino, Martino, Martino, Maruyama, Melody A. Swartz, Mitchell, Ng, Ng, Ng, Norrmen, Olszewski, Paavonen, Pepper, Petrova, Podgrabinska, Priscilla S. Briquez, Rigby, Roth, Rutkowski, Saaristo, Saaristo, Saaristo, Saeki, Schense, Seliktar, Shepro, Swartz, Swartz, Szuba, Tammela, Tomasek, Venugopal, Wetzler, Witold W. Kilarski, Yao   +78 more
core   +1 more source

Myeloid Cells and Lymphangiogenesis [PDF]

Cold Spring Harbor Perspectives in Medicine, 2012
The lymphatic vascular system and the hematopoietic system are intimately connected in ontogeny and in physiology. During embryonic development, mammalian species derive a first lymphatic vascular plexus from the previously formed anterior cardinal vein, whereas birds and amphibians have a lymphatic vascular system of dual origin, composed of lymphatic
Zumsteg, Adrian, Christofori, Gerhard
openaire   +3 more sources

Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma-Associated Herpesvirus-Induced Lymphangiogenesis. [PDF]

, 2018
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent for Kaposi's sarcoma (KS), which is one of the most common HIV-associated neoplasms.
Fan Li, Grace M. Aldrovandi, Hye Ryun Yu, Hye-Ra Lee, Jae U. Jung, Peter Palese, Pinghui Feng, Shou-Jiang Gao, Un Yung Choi, Young-Kwon Hong   +9 more
core   +3 more sources

Lymphangiogenesis [PDF]

Circulation, 2012
At the level of the capillaries, the systemic circulation loses about 2-4 liters of fluid and about 100g of protein into the interstitium daily. This ultrafiltrate of the systemic capillaries is returned to the circulatory system by the lymphatics. The lymphatic vasculature is highly specialized to perform this service, beginning with the blind-ended ...
openaire   +3 more sources

Network development in biological gels: role in lymphatic vessel development [PDF]

, 2008
In this paper, we present a model that explains the prepatterning of lymphatic vessel morphology in collagen gels. This model is derived using the theory of two phase rubber material due to Flory and coworkers and it consists of two coupled fourth order ...
Fowler, A. C., Roose, Tiina
core   +3 more sources

Kuoxin Decoction promotes lymphangiogenesis in zebrafish and in vitro based on network analysis

Frontiers in Pharmacology, 2022
Background: Inadequate lymphangiogenesis is closely related to the occurrence of many kinds of diseases, and one of the important treatments is to promote lymphangiogenesis.
Longping Peng, Mengjiao Ma, Yidan Dong, Qiong Wu, Shiying An, Min Cao, Yi Wang, Chang Zhou, Maolin Zhou, Xu Wang, Qianqian Liang, Qianqian Liang, Qianqian Liang, Youhua Wang   +13 more
doaj   +1 more source

Exosomal circ_0026611 contributes to lymphangiogenesis by reducing PROX1 acetylation and ubiquitination in human lymphatic endothelial cells (HLECs)

Cellular & Molecular Biology Letters, 2023
Background Esophageal squamous carcinoma (ESCC) is a common malignancy that originates in the digestive tract. Lymph node metastasis (LNM) is a complicated process, and tumor lymphangiogenesis has been reported to be associated with the spread of tumor ...
Wenjian Yao, Xiangbo Jia, Li Zhu, Lei Xu, Quan Zhang, Tian Xia, Li Wei   +6 more
doaj   +1 more source

Integrins and Their Extracellular Matrix Ligands in Lymphangiogenesis and Lymph Node Metastasis

International Journal of Cell Biology, 2012
In the 1970s, the late Judah Folkman postulated that tumors grow proportionately to their blood supply and that tumor angiogenesis removed this limitation promoting growth and metastasis. Work over the past 40 years, varying from molecular examination to
Jie Chen, J. Steven Alexander, A. Wayne Orr   +2 more
doaj   +1 more source