Results 81 to 90 of about 23,756 (251)
Cancer Science, EarlyView.Cancer‐associated fibroblasts (CAFs) are the major component of the tumor stroma. This review will highlight the CAF subtypes within the tumor microenvironment and their role in tumor progression. CAF subtype induction by extracellular vesicles (EVs) and their significance, which we reported previously, are also discussed.
Yutaka Naito
wiley +1 more source
The Role of Stromal Tumor Environment in Advancing Skin Cancer Diagnosis and Treatment
International Journal of Dermatology, EarlyView.ABSTRACT The stromal tumor environment (STE) plays a vital yet often underrecognized role in cancer progression, shaping tumor development. It influences complex interactions among stromal cells, immune cells, extracellular matrix (ECM) components, and signaling molecules.
Frank Jing +3 more
wiley +1 more source
Signal Transduction and Targeted TherapyEphrinB2 (erythropoietin-producing hepatoma interactor B2) is a key Eph/ephrin family member, promoting angiogenesis, vasculogenesis, and lymphangiogenesis during embryonic development. However, the role of EphrinB2 in cardiac lymphangiogenesis following
Yingnan Bai +19 more
doaj +1 more source
Cell Transplantation, 2022 Extracellular vesicles from adipose-derived mesenchymal stem cells (ADSCs) play an important role in lymphangiogenesis; however, the underlying mechanisms are not fully understood.
Yi Yang +8 more
doaj +1 more source
Lipedema: Progress, Challenges, and the Road Ahead
Obesity Reviews, EarlyView.ABSTRACT Introduction Lipedema is a chronic and progressive disease that predominantly affects women, characterized by a disproportionate increase in subcutaneous adipose tissue (AT), particularly in the lower limbs. It is associated with significant physical disability, chronic pain, thromboembolism, and psychosocial distress.
Vincenza Cifarelli
wiley +1 more source
Circulation Research, 2019 Rationale: Cardiac lymphangiogenesis contributes to the reparative process post-myocardial infarction, but the factors and mechanisms regulating it are not well understood.
Claire E. Trincot +8 more
semanticscholar +1 more source
Clinical and Experimental Pharmacology and Physiology, Volume 52, Issue 9, September 2025.ABSTRACT Current melanoma treatment results in adverse effects, prompting the use of phytochemicals as adjuvant therapy to reduce the reliance on synthetic drugs and combat drug resistance. This study investigated the in vitro effect of (3‐(4‐Dimethylamino‐naphthelen‐1‐ylmethylene)‐1, 3‐hydroindol‐2‐one) (MAZ‐51) and zingerone, a ginger derivative, on ...
Kganya Letsoalo +3 more
wiley +1 more source
Biological Basis of Therapeutic Lymphangiogenesis [PDF]
Circulation, 2011 The lymphatic vascular system is crucial for the regulation of tissue fluid homeostasis, immune function, and fat metabolism. Lymphatic dysfunction, either due to gene mutations or secondary to damage to the lymph vessels, may lead to lymphedema, a debilitating condition characterized by chronic tissue edema, impaired immunity, and accumulation of ...
Tuomas Tammela +3 more
openaire +3 more sources
Cell Reports, 2019 Summary: Lymphatic vascular development establishes embryonic and adult tissue fluid balance and is integral in disease. In diverse vertebrate organs, lymphatic vessels display organotypic function and develop in an organ-specific manner. In all settings,
Adam J. Vogrin +9 more
doaj
CCN2-induced lymphangiogenesis is mediated by the integrin αvβ5–ERK pathway and regulated by DUSP6
Scientific Reports, 2022 Lymphangiogenesis is essential for the development of the lymphatic system and is important for physiological processes such as homeostasis, metabolism and immunity.
Shiho Hashiguchi +4 more
doaj +1 more source