Results 81 to 90 of about 27,751 (253)
Advanced Science, EarlyView.This study reveals that CAFs‐derived EVs enriched with circTAX1BP1 drive CRLM by promoting VIRMA lactylation and SP1/TGF‐β signaling, creating a positive feedback loop via ITGA11+ myCAFs. Targeting EV‐circTAX1BP1 and TGF‐β disrupts this loop, offering a novel therapeutic strategy for CRLM.
Jia‐nan Tan +12 more
wiley +1 more source
Lymphangiogenesis in the heart
The FASEB Journal, 2009 Our goal was to follow the development of the lymphatic system in the developing heart using markers that identify the lymphatics in adult tissues. The transcription factor Prox‐1 identified a branching network of vessels in the avian embryonic heart that first appeared on the outflow tract at Embryonic Day 5 (Hamburger and Hamilton Stage 25‐26).
Yong Qiu Doughman +8 more
openaire +2 more sources
CRIP1 Reshapes the Gastric Cancer Microenvironment to Facilitate Development of Lymphatic Metastasis
Advanced Science, 2023 Lymphangiogenesis in tumors provides an auxiliary route for cancer cell invasion to drainage lymph nodes, facilitating the development of lymphatic metastasis (LM).
Zhonghua Wu +9 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Endometriosis is a highly prevalent proinflammatory disease without reliable diagnostic biomarkers and cannot be cured by nowadays’ medical treatments.
Wan-Ning Li +8 more
semanticscholar +1 more source
Cytometry Part B: Clinical Cytometry, EarlyView.Abstract Acute promyelocytic leukemia (APL) is a medical emergency that needs immediate diagnosis and treatment. Podoplanin, a transmembrane glycoprotein that binds CLEC‐2 on platelets, was recently demonstrated to be abnormally expressed in leukemic blasts in APL, as opposed to other forms of AML, in a study using thawed primary cells.
Camilla Maria de Alencar Saraiva +7 more
wiley +1 more source
Cow's milk protein allergy with protein‐losing enteropathy under the scope
JPGN Reports, EarlyView.ABSTRACT Objectives Cow's milk protein allergy (CMPA) is very frequent in infants. Presentation is variable, and symptoms fluctuate in intensity. Diagnosis can be challenging as it is mostly clinical. In severe cases, patients can present with anasarca secondary to protein‐losing enteropathy (PLE).
Morgane Thorens‐Borgeat +6 more
wiley +1 more source
Biological Basis of Therapeutic Lymphangiogenesis [PDF]
Circulation, 2011 The lymphatic vascular system is crucial for the regulation of tissue fluid homeostasis, immune function, and fat metabolism. Lymphatic dysfunction, either due to gene mutations or secondary to damage to the lymph vessels, may lead to lymphedema, a debilitating condition characterized by chronic tissue edema, impaired immunity, and accumulation of ...
Tuomas Tammela +3 more
openaire +3 more sources
Targeting glycolytic reprogramming by tsRNA-0032 for treating pathological lymphangiogenesis
Cell Death and DiseaseLymphangiogenesis is vital for tissue fluid homeostasis, immune function, and lipid absorption. Abnormal lymphangiogenesis has been implicated in several diseases such as cancers, inflammatory, and autoimmune diseases.
Fan Ye +7 more
doaj +1 more source
Atypical E2fs control lymphangiogenesis through transcriptional regulation of Ccbe1 and Flt4. [PDF]
PLoS ONE, 2013 Lymphatic vessels are derived from venous endothelial cells and their formation is governed by the Vascular endothelial growth factor C (VegfC)/Vegf receptor 3 (Vegfr3; Flt4) signaling pathway.
Bart G M W Weijts +3 more
doaj +1 more source
Oncogene, 2018 Cancer-secreted exosomal miRNAs are emerging mediators of cancer-stromal cross-talk in the tumor environment. Our previous miRNAs array of cervical squamous cell carcinoma (CSCC) clinical specimens identified upregulation of miR-221-3p.
Chenfei Zhou +11 more
semanticscholar +1 more source