Results 181 to 190 of about 23,592 (245)

Pink Polypoid Papulo‐Vesicles on Labia Majora

JEADV Clinical Practice, EarlyView.
Maria Chiara Mercuri, Michela Tabanelli, Silvia Zago, Diego Abbenante   +3 more
wiley   +1 more source

Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?

The Journal of Pathology, EarlyView.
Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi, Irene Torresan, Emilio Francesco Giunta, Sara Bleve, Nicole Brighi, Elisa Tassinari, Sofia Zanuccoli, Maria Concetta Cursano, Cristian Lolli   +8 more
wiley   +1 more source

When Fat Goes Astray: Your Liver and Pancreas Get Into Trouble

Portal Hypertension &Cirrhosis, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) and intrapancreatic fat deposition (IPFD) are both common manifestations of ectopic fat accumulation. Although they share multiple risk factors, they also show notable differences in pathological features, standardization of diagnosis, and research maturity.
Yuying Chen, Li Ding, Shan Zhao, Weihong Wang, Jing Zhong, Qiang Yan   +5 more
wiley   +1 more source

Aging Theories and Prevention of Age-Related Diseases Using Phytocomplexes. [PDF]

Biology (Basel)
Khanturin MR, Demchenko GA, Koibasova LU, Abdreshov SN, Yessenova MA, Imankulova SK, Akhatayeva YN.   +6 more
europepmc   +1 more source

A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet, Klas Petersson, Marc C. Huisman, C. Willemien Menke‐van der Houven van Oordt, Iris H. C. Miedema, Andrea Thiele, Ghazal Montaseri, Alejandro Pérez‐Pitarch, David Busse   +8 more
wiley   +1 more source

Diagnostic challenges and perioperative management of a lateral cystic neck mass in an adult patient with hemophilia B: A case report. [PDF]

SAGE Open Med Case Rep
Ruley WG, Greene WA, Cranfield DA, Vasan NR.   +3 more
europepmc   +1 more source

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, EarlyView.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source

3D‐Printed Milli‐Fluidic Mixing‐Extrusion Platform for Continuous, High‐Throughput LNP Production

Small, EarlyView.
We report a continuous high‐throughput production of lipid nanoparticles (LNPs) by integrating a reusable 3D‐printed milli‐fluidic split‐and‐recombine mixer with inline membrane extrusion. The 3D architecture enables rapid early‐stage mixing, reducing clogging and fouling, while inline extrusion further refines the as‐formed LNPs, improving uniformity,
Leekang Jeon, Seeun Kim, Hanjin Seo, Hyun Su Lee, Gi‐Su Na, Gi‐Ra Yi, Hyomin Lee   +6 more
wiley   +1 more source

Cardiomyocyte-Derived Apelin Rescues Viral Myocarditis-Induced Cardiac Lymphatic Dysfunction and Remodeling. [PDF]

JACC Basic Transl Sci
Lin YN, Xu J, Wu YH, Jin MX, Wang YT, Wu YQ, Zhan HH, Qian XG, Wang ZN, Lei-Wang, Li YC.   +10 more
europepmc   +1 more source

Theranostic π Electron‐Stabilized Polymeric Micelles for PET Imaging‐Guided Drug Delivery to Tumors

Small, EarlyView.
Cancer nanomedicine efficacy is limited by heterogeneous nanoparticle accumulation in tumors. Nuclear imaging offers non‐invasive, patient‐ and lesion‐specific visualization and quantification of nanoparticle uptake. We present a positron emission tomography (PET)‐imageable micelle platform for direct quantification of nanoparticle accumulation and ...
Alec Wang, Alexandru Florea, Jan‐Niklas May, Zaheer Ahmed, Karolin Roemhild, Thomas Hansen, Rahaf Mihyar, Armin Azadkhah Shalmani, Laura Schäfer, Karolin Becker, Masoud Sadeghzadeh, Eva M. Buhl, Sven Thoröe‐Boveleth, Susanne Lütje, Agnieszka Morgenroth, Fabian Kiessling, Jochen Maurer, Josbert M. Metselaar, Yang Shi, Felix M. Mottaghy, Quim Peña, Twan Lammers   +21 more
wiley   +1 more source