Paraxial Mesoderm Is the Major Source of Lymphatic Endothelium. [PDF]
Dev Cell, 2019 Stone OA, Stainier DYR.
europepmc +3 more sources
The prognostic influence of lymphatic endothelium-specific hyaluronan receptor 1 in cancer: A systematic review. [PDF]
Cancer Sci, 2022 Lymphangiogenesis is a key process in cancer development and metastasis. Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE‐1) is a widely used marker for lymphatic endothelial cells (LEC), which also mediates immune and cancer cell migration ...
Karinen S, Hujanen R, Salo T, Salem A.
europepmc +2 more sources
Tumour cells express functional lymphatic endothelium-specific hyaluronan receptor in vitro and in vivo: Lymphatic mimicry promotes oral oncogenesis? [PDF]
Oncogenesis, 2021 Lymphatic metastasis represents the main route of tumour cell dissemination in oral squamous cell carcinoma (OSCC). Yet, there are no FDA-approved therapeutics targeting cancer-related lymphangiogenesis to date.
Karinen S +9 more
europepmc +2 more sources
Direct specification of lymphatic endothelium from non-venous angioblasts
bioRxiv, 2022 The lymphatic vasculature is essential for tissue fluid homeostasis, immune cell surveillance and dietary lipid absorption, and has emerged as a key regulator of organ growth and repair1.
Lupu I +10 more
europepmc +2 more sources
Identification of lymphatic endothelium in cranial arachnoid granulation-like dural gap [PDF]
Microscopy, 2020 The dynamics of cerebrospinal fluid (CSF) are essential for maintaining homeostasis in the central nerve system. Despite insufficiently detailed descriptions of their structural and molecular properties for a century, cranial arachnoid granulations (CAGs)
Osamu Kutomi, Sén Takeda
openalex +2 more sources
Apelin modulates pathological remodeling of lymphatic endothelium after myocardial infarction. [PDF]
JCI Insight, 2017 Lymphatic endothelium serves as a barrier to control fluid balance and immune cell trafficking to maintain tissue homeostasis. Long-term alteration of lymphatic vasculature promotes edema and fibrosis, which is an aggravating factor in the onset of ...
Tatin F +11 more
europepmc +2 more sources
Immunomodulatory properties of the lymphatic endothelium in the tumor microenvironment [PDF]
Frontiers in Immunology, 2023 The tumor microenvironment (TME) is an intricate complex and dynamic structure composed of various cell types, including tumor, stromal and immune cells.
Cristina Viúdez-Pareja +5 more
doaj +2 more sources
Insulin resistance disrupts cell integrity, mitochondrial function, and inflammatory signaling in lymphatic endothelium. [PDF]
Microcirculation, 2018 Lymphatic vessel dysfunction and increased lymph leakage have been directly associated with several metabolic diseases. However, the underlying cellular mechanisms causing lymphatic dysfunction have not been determined. Aberrant insulin signaling affects
Lee Y +3 more
europepmc +2 more sources
Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation. [PDF]
Elife, 2018 Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood.
Pekkonen P +17 more
europepmc +2 more sources
Calcium and electrical dynamics in lymphatic endothelium [PDF]
Journal of Physiology, 2017 Endothelial cell function in resistance arteries integrates Ca2+ signalling with hyperpolarization to promote relaxation of smooth muscle cells and increase tissue blood flow.
Erik J. Behringer +7 more
openalex +2 more sources