The prognostic influence of lymphatic endothelium-specific hyaluronan receptor 1 in cancer: A systematic review. [PDF]
Cancer Sci, 2022 Lymphangiogenesis is a key process in cancer development and metastasis. Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE‐1) is a widely used marker for lymphatic endothelial cells (LEC), which also mediates immune and cancer cell migration ...
Karinen S, Hujanen R, Salo T, Salem A.
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The Lymphatic Endothelium in the Context of Radioimmuno-Oncology. [PDF]
Cancers (Basel), 2022 The study of lymphatic tumor vasculature has been gaining interest in the context of cancer immunotherapy. These vessels constitute conduits for immune cells’ transit toward the lymph nodes, and they endow tumors with routes to metastasize to the lymph nodes and, from them, toward distant sites.
Suárez L +2 more
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Paraxial Mesoderm Is the Major Source of Lymphatic Endothelium. [PDF]
Dev Cell, 2019 Endothelial cells (ECs), which line blood and lymphatic vessels, are generally described to come from the lateral plate mesoderm despite experimental evidence for a broader source of origin, including the paraxial mesoderm (PXM). Current dogma suggests that following specification from mesoderm, local environmental cues establish the distinct molecular
Stone OA, Stainier DYR.
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microRNAs in the Lymphatic Endothelium: Master Regulators of Lineage Plasticity and Inflammation. [PDF]
Front Immunol, 2017 microRNAs (miRNAs) are highly conserved, small non-coding RNAs that regulate gene expression at the posttranscriptional level. They have crucial roles in organismal development, homeostasis, and cellular responses to pathological stress.
Yee D, Coles MC, Lagos D.
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Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium. [PDF]
NatureLymphatic capillaries continuously take up interstitial fluid and adapt to resulting changes in vessel calibre1, 2–3. The mechanisms by which the permeable monolayer of loosely connected lymphatic endothelial cells (LECs)4 maintains mechanical stability ...
Schoofs H +21 more
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Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation. [PDF]
Elife, 2018 Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood.
Pekkonen P +17 more
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Insulin resistance disrupts cell integrity, mitochondrial function, and inflammatory signaling in lymphatic endothelium. [PDF]
Microcirculation, 2018 Lymphatic vessel dysfunction and increased lymph leakage have been directly associated with several metabolic diseases. However, the underlying cellular mechanisms causing lymphatic dysfunction have not been determined. Aberrant insulin signaling affects
Lee Y +3 more
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Dendritic cell interactions with lymphatic endothelium. [PDF]
Lymphat Res Biol, 2013 Afferent lymphatic vessels fulfill essential immune functions by transporting leukocytes and lymph-borne antigen to draining lymph nodes (dLNs). An important cell type migrating through lymphatic vessels are dendritic cells (DCs). DCs reside in peripheral tissues like the skin, where they take up antigen and transport it via the lymphatic vascular ...
Russo E, Nitschké M, Halin C.
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Homodimerization of the Lymph Vessel Endothelial Receptor LYVE-1 through a Redox-labile Disulfide Is Critical for Hyaluronan Binding in Lymphatic Endothelium. [PDF]
J Biol Chem, 2016 The lymphatic vessel endothelial receptor LYVE-1 is implicated in the uptake of hyaluronan (HA) and trafficking of leukocytes to draining lymph nodes. Yet LYVE-1 has only weak affinity for hyaluronan and depends on receptor clustering and higher order ...
Banerji S +8 more
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mTOR-Dependent Stimulation of IL20RA Orchestrates Immune Cell Trafficking through Lymphatic Endothelium in Patients with Crohn’s Disease [PDF]
Cells, 2019 Crohn’s disease (CD) is a chronic inflammatory condition that can affect different portions of the gastrointestinal tract. Lymphatic drainage was demonstrated to be dysfunctional in CD pathogenesis, ultimately causing the failure of the resolution ...
Federica Ungaro +13 more
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