Emerging roles of lymphatic endothelium in regulating adaptive immunity. [PDF]
J Clin Invest, 2014 Emerging research on the roles of stromal cells in modulating adaptive immune responses has included a new focus on lymphatic endothelial cells (LECs). LECs are presumably the first cells that come into direct contact with peripheral antigens, cytokines, danger signals, and immune cells travelling from peripheral tissues to lymph nodes.
Card CM, Yu SS, Swartz MA.
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Hematopoietic stem cells contribute to lymphatic endothelium.
PLoS ONE, 2008 BackgroundAlthough the lymphatic system arises as an extension of venous vessels in the embryo, little is known about the role of circulating progenitors in the maintenance or development of lymphatic endothelium.
Shuguang Jiang +6 more
doaj +6 more sources
microRNAs in the Lymphatic Endothelium: Master Regulators of Lineage Plasticity and Inflammation. [PDF]
Front Immunol, 2017 microRNAs (miRNAs) are highly conserved, small non-coding RNAs that regulate gene expression at the posttranscriptional level. They have crucial roles in organismal development, homeostasis, and cellular responses to pathological stress.
Yee D, Coles MC, Lagos D.
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Calcium and electrical dynamics in lymphatic endothelium [PDF]
The Journal of Physiology, 2017 Key points Endothelial cell function in resistance arteries integrates Ca2+ signalling with hyperpolarization to promote relaxation of smooth muscle cells and increase tissue blood flow. Whether complementary signalling occurs in lymphatic endothelium is unknown.
Erik J. Behringer +7 more
semanticscholar +5 more sources
The Lymphatic Endothelium in the Context of Radioimmuno-Oncology. [PDF]
Cancers (Basel), 2022 The study of lymphatic tumor vasculature has been gaining interest in the context of cancer immunotherapy. These vessels constitute conduits for immune cells’ transit toward the lymph nodes, and they endow tumors with routes to metastasize to the lymph nodes and, from them, toward distant sites.
Suárez L +2 more
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The prognostic influence of lymphatic endothelium-specific hyaluronan receptor 1 in cancer: A systematic review. [PDF]
Cancer Sci, 2022 Lymphangiogenesis is a key process in cancer development and metastasis. Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE‐1) is a widely used marker for lymphatic endothelial cells (LEC), which also mediates immune and cancer cell migration ...
Karinen S, Hujanen R, Salo T, Salem A.
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Tumour cells express functional lymphatic endothelium-specific hyaluronan receptor in vitro and in vivo: Lymphatic mimicry promotes oral oncogenesis? [PDF]
Oncogenesis, 2021 Lymphatic metastasis represents the main route of tumour cell dissemination in oral squamous cell carcinoma (OSCC). Yet, there are no FDA-approved therapeutics targeting cancer-related lymphangiogenesis to date.
Karinen S +9 more
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Direct specification of lymphatic endothelium from mesenchymal progenitors. [PDF]
Nat Cardiovasc ResAbstract During embryogenesis, endothelial cells (ECs) are generally described to arise from a common pool of progenitors termed angioblasts, which diversify through iterative steps of differentiation to form functionally distinct subtypes of ECs.
Lupu IE +17 more
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Direct specification of lymphatic endothelium from non-venous angioblasts
bioRxiv, 2022 The lymphatic vasculature is essential for tissue fluid homeostasis, immune cell surveillance and dietary lipid absorption, and has emerged as a key regulator of organ growth and repair1.
Lupu I +10 more
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Identification of lymphatic endothelium in cranial arachnoid granulation-like dural gap [PDF]
Microscopy, 2020 The dynamics of cerebrospinal fluid (CSF) are essential for maintaining homeostasis in the central nerve system. Despite insufficiently detailed descriptions of their structural and molecular properties for a century, cranial arachnoid granulations (CAGs)
Osamu Kutomi, Sén Takeda
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