Results 41 to 50 of about 128,807 (261)

Space Jam‐Ming: Generating Interstitial Space Using Fragmented Granular GelMA to Investigate Novel Paradigms of Cancer Metastasis

open access: yesAdvanced Science, EarlyView.
Microgels enable independent control of stiffness and interstitial space, overcoming limitations of conventional 3D hydrogels. Using fragmented gelatin methacryloyl microgels, we show that stiffness does not restrict non‐metastatic breast cancer growth, contrary to bulk hydrogels, and reveal the role of adherent‐to‐suspension transition in cancer ...
Danielle Vahala   +15 more
wiley   +1 more source

Airway response to sirolimus therapy for the treatment of complex pediatric lymphatic malformations

open access: yes, 2015
Head and neck lymphatic malformations can create airway management challenges requiring tracheotomy. Sirolimus, an inhibitor of mammalian target of rapamycin (mTOR), may inhibit growth of lymphatic malformations.
Rosbe, Kristina W   +3 more
core   +1 more source

Lymphatic vascular morphogenesis in development, physiology, and disease [PDF]

open access: yes, 2011
The lymphatic vasculature constitutes a highly specialized part of the vascular system that is essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune response. Recently, there has been an increased awareness of the
Amélie Sabine   +9 more
core   +2 more sources

Assessment of PI3K/AKT and MAPK/ERK pathways activation in oral lymphatic malformations [PDF]

open access: yes, 2021
Objetivo: As malformações linfáticas são caracterizadas pelo crescimento excessivo dos vasos linfáticos durante o desenvolvimento. A ativação das vias de sinalização PI3K/AKT e MAPK/ERK ocorre em malformações linfáticas isoladas e naquelas associadas a ...
Letícia Martins Guimarães   +6 more
core   +1 more source

Layer‐Specific Dermal and Subcutaneous Delivery via Modular LNP–Hydrogel‐Integrated Threaded Microneedles

open access: yesAdvanced Science, EarlyView.
Guided by spatial transcriptomics and clinical validation, a threaded microneedle platform enables precise layer‐specific delivery across the dermis and subcutaneous tissue. By addressing distinct pathogenic remodeling in different skin layers, this strategy coordinates compartment‐specific intervention, restores tissue architecture, and offers a ...
Fangzhou Xie   +14 more
wiley   +1 more source

A 61-year-old woman with jejunal lymphatic malformation visualized on computed tomography: a case report

open access: yesJournal of Medical Case Reports, 2021
Background Jejunal lymphatic malformations are congenital lesions that are seldom diagnosed in adults and rarely seen on imaging. Case presentation A 61-year-old Caucasian woman was initially diagnosed and treated for mucinous ovarian carcinoma. After an
Mark Rupasinghe   +6 more
doaj   +1 more source

Orbital Lymphatic-Venous Malformation Accompanied by an Intraocular Vascular Malformation: A Rare Case Study

open access: yesCase Reports in Ophthalmology, 2021
Lymphatic-venous malformations (LVMs) are development defects that result in abnormal connections between the lymphatic and venous systems. The authors describe a 7-weeks-old female infant who presented with a right orbital LVM extending to the ...
Karny Shouchane-Blum   +7 more
doaj   +1 more source

A case series of fetal lymphatic malformations and a review of the literature

open access: yes, 2023
: Lymphatic malformations are rare benign developmental anomalies of the lymphatic system that can be diagnosed by prenatal ultrasound. Depending on their anatomical site and size, the lesions can cause a variety of aesthetic and functional deficits ...
Papaccio, M   +5 more
core   +1 more source

Tumor Mechanical Remodeling via Bidirectional Calcium Redistribution Enables Deep Photothermal‐Immunotherapy

open access: yesAdvanced Science, EarlyView.
A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao   +9 more
wiley   +1 more source

Transoral Sclerotherapy for Deep Space Cervical Lymphatic Malformations in Children With Acute Airway Compromise

open access: yes, 2015
Introduction: Cervical lymphatic malformations in children rarely present with acute airway compromise. During an acute exacerbation or hemorrhage, lymphatic malformations involving the deep neck spaces may precipitate critical airway obstruction.
Yoo, M. J., Cheng, J.
core   +1 more source

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