Results 231 to 240 of about 732,589 (264)

Molecular Control of Lymphatic Metastasis

Annals of the New York Academy of Sciences, 2008
The metastatic spread of tumor cells is the most lethal aspect of cancer and often occurs via the lymphatic vasculature. Both experimental tumor models and human clinicopathologic data indicate that growth of lymphatic vessels (lymphangiogenesis) near solid tumors is often associated with lymph node metastasis.
Marc G, Achen, Steven A, Stacker
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Lymphatic Metastasis in the Absence of Functional Intratumor Lymphatics

Science, 2002
Lymphatic metastasis contributes to mortality from solid tumors. Whether metastasizing cancer cells reach lymph nodes via intratumor lymphatic vessels is unknown. Here, we examine functional lymphatics associated with mouse tumors expressing normal or elevated levels of vascular endothelial growth factor–C (VEGF-C), a molecule that stimulates ...
Timothy P, Padera, Ananth, Kadambi, Emmanuelle, di Tomaso, Carla Mouta, Carreira, Edward B, Brown, Yves, Boucher, Noah C, Choi, Douglas, Mathisen, John, Wain, Eugene J, Mark, Lance L, Munn, Rakesh K, Jain   +11 more
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Lymphatic metastasis

CANCER AND METASTASIS REVIEW, 1983
Lymphatic metastasis is an important mechanism in the spread of human cancer. During its course, tumor cells first penetrate the basement of membrane of the epithelium, in which they arise, and then the underlying connective tissue, carried partly by hydrostatic pressure.
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ANXA3-rich exosomes derived from tumor-associated macrophages regulate ferroptosis and lymphatic metastasis of laryngeal squamous cell carcinoma.

Cancer immunology research
Tumor-associated macrophages (TAMs) induce immunosuppression in laryngeal squamous cell carcinoma (LSCC). The interaction between LSCC cells and TAMs affects the progression of laryngeal cancer through exosomes, but the underlying molecular mechanism ...
Licheng Xu, Wenjing Li, Danxi Liu, Jing Cao, J. Ge, Xinyu Liu, Yue Wang, Yujian Teng, Pengyan Liu, Xinyue Guo, Chen He, Ming Liu, L. Tian   +12 more
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Experimental lymphatic metastasis

Journal of Microscopy, 1983
SUMMARYA model of lymphatic metastasis of cancer has been established by injecting tumour cells into the rat footpad and examining the draining popliteal lymph node. The node can probably destroy only a few tumour cells; thereafter metastasis is progressive and lethal.
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Gastrointestinal cancer metastasis and lymphatic advancement

Surgery Today, 2010
The role of angiogenesis in the growth of solid tumors is well established, but the role of lymphatic vessels and the relationship between lymphangiogenesis and tumor spread are less clear. Recently, the molecular pathway that signals lymphangiogenesis and specific markers for lymphatic endothelium have been discovered; however, the lymphatic pathway ...
Kazuhide, Kumagai, Kouji, Shimizu, Noboru, Yokoyama, Sadatsugu, Aida, Takayuki, Tanaka, Kennichi, Yamagata   +5 more
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Adhesion mechanisms in lymphatic metastasis

Cancer and Metastasis Review, 1991
The role of cellular adhesion in regional lymph node metastasis of solid tumors has been investigated. The data reviewed is based on studies in four different tumor models of human, rat and murine origin. An in vitro assay measuring tumor cell attachment to cryostat sections of normal peripheral lymph nodes, obtained from the species of tumor origin ...
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Lymphatic function, lymphangiogenesis, and cancer metastasis

Microscopy Research and Technique, 2001
AbstractThe lymphatic system serves as the primary route for the metastasis of many cancers and the extent of lymph node involvement is the most important indicator of tumor aggressiveness. Despite the apparent importance of the lymphatic vessels for tumor dissemination, it has remained unclear whether activation of lymphatic endothelial cells may ...
M A, Swartz, M, Skobe
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Lymphatic Metastasis of Neoplasms

1983
Human cancers commonly metastasize by the lymphatics to draining lymph nodes. The existence of lymphatic vessels has been known since the observations of Aselli in 1622 and the fact that cancer can spread to lymph nodes was “well-known”to Pearson in 1793 (reviewed by Mayerson, 1969; Onuigbo, 1972).
Ian Carr, Jean Carr
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Targeted Treatment for Lymphedema and Lymphatic Metastasis

Annals of the New York Academy of Sciences, 2008
The presence of lymphatic vessels has been known for centuries, but the key players regulating the lymphatic vessel growth and function have only been discovered during the recent decade. The lymphatic vasculature is essential for maintenance of normal fluid balance and for the immune response.
Tomi, Tervala, Erkki, Suominen, Anne, Saaristo   +2 more
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