Results 221 to 230 of about 95,502 (256)

Molecular Control of Lymphatic Metastasis

Annals of the New York Academy of Sciences, 2008
The metastatic spread of tumor cells is the most lethal aspect of cancer and often occurs via the lymphatic vasculature. Both experimental tumor models and human clinicopathologic data indicate that growth of lymphatic vessels (lymphangiogenesis) near solid tumors is often associated with lymph node metastasis.
Marc G, Achen, Steven A, Stacker
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Lymphatic metastasis

CANCER AND METASTASIS REVIEW, 1983
Lymphatic metastasis is an important mechanism in the spread of human cancer. During its course, tumor cells first penetrate the basement of membrane of the epithelium, in which they arise, and then the underlying connective tissue, carried partly by hydrostatic pressure.
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Lymphatic function, lymphangiogenesis, and cancer metastasis

Microscopy Research and Technique, 2001
AbstractThe lymphatic system serves as the primary route for the metastasis of many cancers and the extent of lymph node involvement is the most important indicator of tumor aggressiveness. Despite the apparent importance of the lymphatic vessels for tumor dissemination, it has remained unclear whether activation of lymphatic endothelial cells may ...
Melody A Swartz, Mihaela Skobe
exaly   +3 more sources

Targeting Lymphatic Metastasis

Science, 2002
Oncologists have long debated the part played by the lymphatic system of cancer patients in tumor metastasis. In a Perspective, Gershenwald and Fidler discuss new findings ( Padera et al .) showing that the lymphatic vessels surrounding tumors contribute to lymphatic metastasis.
Jeffrey E. Gershenwald, Isaiah J. Fidler
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Adhesion mechanisms in lymphatic metastasis

Cancer and Metastasis Review, 1991
The role of cellular adhesion in regional lymph node metastasis of solid tumors has been investigated. The data reviewed is based on studies in four different tumor models of human, rat and murine origin. An in vitro assay measuring tumor cell attachment to cryostat sections of normal peripheral lymph nodes, obtained from the species of tumor origin ...
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Gastrointestinal cancer metastasis and lymphatic advancement

Surgery Today, 2010
The role of angiogenesis in the growth of solid tumors is well established, but the role of lymphatic vessels and the relationship between lymphangiogenesis and tumor spread are less clear. Recently, the molecular pathway that signals lymphangiogenesis and specific markers for lymphatic endothelium have been discovered; however, the lymphatic pathway ...
Kazuhide, Kumagai, Kouji, Shimizu, Noboru, Yokoyama, Sadatsugu, Aida, Takayuki, Tanaka, Kennichi, Yamagata   +5 more
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Targeted Treatment for Lymphedema and Lymphatic Metastasis

Annals of the New York Academy of Sciences, 2008
The presence of lymphatic vessels has been known for centuries, but the key players regulating the lymphatic vessel growth and function have only been discovered during the recent decade. The lymphatic vasculature is essential for maintenance of normal fluid balance and for the immune response.
Tomi, Tervala, Erkki, Suominen, Anne, Saaristo   +2 more
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The evolving role of lymphatics in cancer metastasis

Current Opinion in Immunology, 2018
While the link between the lymphatic system and the metastatic spread of cancer is centuries old, understanding of the underlying mechanisms is still evolving. Lymphatic vessels provide a route for tumour cells to reach regional lymph nodes (LNs), which is prognostic of distant organ metastasis and poor survival. However, genomic analyses of metastatic
Rae H, Farnsworth, Marc G, Achen, Steven A, Stacker   +2 more
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Molecular mechanisms and imaging of lymphatic metastasis

Experimental Cell Research, 2013
In many types of cancer, tumors metastasize through the lymphatic system to draining lymph nodes. These sentinel lymph nodes have gained increased attention as a prognostic indicator for the severity of the disease, leading to the sentinel lymph node mapping and biopsy procedure to be accepted as standard-of-care for breast cancer and melanoma. However,
Proulx ST, Detmar M
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Lymphatic Metastasis of Neoplasms

1983
Human cancers commonly metastasize by the lymphatics to draining lymph nodes. The existence of lymphatic vessels has been known since the observations of Aselli in 1622 and the fact that cancer can spread to lymph nodes was “well-known”to Pearson in 1793 (reviewed by Mayerson, 1969; Onuigbo, 1972).
Ian Carr, Jean Carr
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