Results 1 to 10 of about 988,280 (306)

Lymphatic vessel: Origin, heterogeneity, biological functions and therapeutic targets [PDF]

Signal Transduction and Targeted Therapy
Lymphatic vessels, comprising the secondary circulatory system in human body, play a multifaceted role in maintaining homeostasis among various tissues and organs.
Zhaoliang Hu, Xushi Zhao, Zhonghua Wu, Bicheng Qu, Minxian Yuan, Yanan Xing, Yongxi Song, Zhenning Wang   +7 more
doaj   +3 more sources

Biomechanical control of lymphatic vessel physiology and functions. [PDF]

Cell Mol Immunol, 2023
The ever-growing research on lymphatic biology has clearly identified lymphatic vessels as key players that maintain human health through their functional roles in tissue fluid homeostasis, immunosurveillance, lipid metabolism and inflammation.
Angeli V, Lim HY.
europepmc   +2 more sources

Impaired meningeal lymphatic vessel development worsens stroke outcome [PDF]

Journal of Cerebral Blood Flow and Metabolism, 2019
The discovery of meningeal lymphatic vessels (LVs) has sparked interest in identifying their role in diseases of the central nervous system. Similar to peripheral LVs, meningeal LVs depend on vascular endothelial growth factor receptor-3 (VEGFR3 ...
Pavel Yanev, Katherine Poinsatte, Devon Hominick, Noor Khurana, Kielen R. Zuurbier, Marcus Berndt, Erik J. Plautz, Michael T. Dellinger, Ann Stowe   +8 more
openalex   +2 more sources

Loss of Primary Cilia Protein IFT20 Dysregulates Lymphatic Vessel Patterning in Development and Inflammation

Frontiers in Cell and Developmental Biology, 2021
Microenvironmental signals produced during development or inflammation stimulate lymphatic endothelial cells to undergo lymphangiogenesis, in which they sprout, proliferate, and migrate to expand the vascular network.
Delayna Paulson, Delayna Paulson, Rebecca Harms, Rebecca Harms, Cody Ward, Cody Ward, Mackenzie Latterell, Mackenzie Latterell, Gregory J. Pazour, Darci M. Fink, Darci M. Fink   +10 more
doaj   +2 more sources

Inhibiting corneal transplantation rejection via lymphatic vessel ligation in a novel murine model [PDF]

Scientific Reports
The lymphatic system is a crucial contributor to allograft rejection after corneal transplantation. However, no surgical procedures for the central pathway where conjunctival lymphatic vessels converge have been investigated.
Ami Igarashi, Takahiko Hayashi, Toshiki Shimizu, Kentaro Yuda, Satoru Yamagami   +4 more
doaj   +2 more sources

High lymphatic vessel density and presence of lymphovascular invasion both predict poor prognosis in breast cancer

BMC Cancer, 2017
Background Lymphatic vessel density and lymphovascular invasion are commonly assessed to identify the clinicopathological outcomes in breast cancer. However, the prognostic values of them on patients’ survival are still uncertain.
Song Zhang, Dong Zhang, Mingfu Gong, Li Wen, Cuiwei Liao, Liguang Zou   +5 more
doaj   +2 more sources

Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms

Nature Communications, 2018
VEGF-C is a key regulator of lymphatic development. Here, Zhang et al. show that while complete loss of its receptor VEGFR3 results in vessel hypoplasia, mosaic loss of VEGFR3 leads to hyperplasia through induction of cell proliferation in neighboringnon-
Yan Zhang, Maria H. Ulvmar, Lukas Stanczuk, Ines Martinez-Corral, Maike Frye, Kari Alitalo, Taija Mäkinen   +6 more
doaj   +2 more sources

Mechanical forces in lymphatic vessel development: Focus on transcriptional regulation [PDF]

Frontiers in Physiology, 2022
The lymphatic system is crucial for the maintenance of interstitial fluid and protein homeostasis. It has important roles in collecting excess plasma and interstitial fluid leaked from blood vessels, lipid absorption and transportation in the digestive ...
Naoto Ujiie, Tsutomu Kume
doaj   +2 more sources

Hydrogen sulfide donor activates AKT-eNOS signaling and promotes lymphatic vessel formation. [PDF]

PLoS ONE, 2023
The lymphatic network is pivotal for various physiological functions in the human body. Accumulated evidence supports the role of therapeutic lymphangiogenesis in the treatment of several pathologies.
Ravi Varma Aithabathula, Naveed Pervaiz, Ishita Kathuria, Mallory Swanson, Udai P Singh, Santosh Kumar, Frank Park, Bhupesh Singla   +7 more
doaj   +2 more sources

A 3D Human Lymphatic Vessel-on-Chip Reveals the Roles of Interstitial Flow and VEGF-A/C for Lymphatic Sprouting and Discontinuous Junction Formation. [PDF]

Cell Mol Bioeng, 2023
Ilan IS, Yslas AR, Peng Y, Lu R, Lee E.
europepmc   +3 more sources