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Lymphatic vessel: Origin, heterogeneity, biological functions and therapeutic targets [PDF]
Signal Transduction and Targeted TherapyLymphatic vessels, comprising the secondary circulatory system in human body, play a multifaceted role in maintaining homeostasis among various tissues and organs.
Zhaoliang Hu +7 more
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Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms [PDF]
Nature Communications, 2018 VEGF-C is a key regulator of lymphatic development. Here, Zhang et al. show that while complete loss of its receptor VEGFR3 results in vessel hypoplasia, mosaic loss of VEGFR3 leads to hyperplasia through induction of cell proliferation in neighboringnon-
Yan Zhang +6 more
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Inhibiting corneal transplantation rejection via lymphatic vessel ligation in a novel murine model [PDF]
Scientific ReportsThe lymphatic system is a crucial contributor to allograft rejection after corneal transplantation. However, no surgical procedures for the central pathway where conjunctival lymphatic vessels converge have been investigated.
Ami Igarashi +4 more
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Mechanical forces in lymphatic vessel development: Focus on transcriptional regulation [PDF]
Frontiers in Physiology, 2022 The lymphatic system is crucial for the maintenance of interstitial fluid and protein homeostasis. It has important roles in collecting excess plasma and interstitial fluid leaked from blood vessels, lipid absorption and transportation in the digestive ...
Naoto Ujiie, Tsutomu Kume
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Hydrogen sulfide donor activates AKT-eNOS signaling and promotes lymphatic vessel formation. [PDF]
PLoS ONE, 2023 The lymphatic network is pivotal for various physiological functions in the human body. Accumulated evidence supports the role of therapeutic lymphangiogenesis in the treatment of several pathologies.
Ravi Varma Aithabathula +7 more
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Hemorrhage Into Lymphatic Vessels [PDF]
Military Medicine, 1953 Lothar Wirth
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Lymphatic vessel network injury reduces local tumor control despite preservation of the tumor-draining lymph node [PDF]
Scientific ReportsThe lymphatic system plays complex, often contradictory, roles in many cancers, including melanoma; these roles include contributions to tumor cell metastasis and immunosuppression in the tumor microenvironment as well as generation of antitumor immunity.
Lauren N. Liebman +6 more
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Frontiers in Physiology, 2022 Aberrant lymphatic system function has been increasingly implicated in pathologies such as lymphedema, organ transplant rejection, cardiovascular disease, obesity, and neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease ...
Faisal Masood +5 more
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PLoS ONE, 2021 In the present study, we aimed to identify the normal hindlimb lymphatic systems in rats and compare them with the detours after lymphatic flow blockage.
Yuiko Suzuki +4 more
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Frontiers in Cell and Developmental Biology, 2021 Microenvironmental signals produced during development or inflammation stimulate lymphatic endothelial cells to undergo lymphangiogenesis, in which they sprout, proliferate, and migrate to expand the vascular network.
Delayna Paulson +10 more
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