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Lymphatic vessel: Origin, heterogeneity, biological functions and therapeutic targets [PDF]
Signal Transduction and Targeted TherapyLymphatic vessels, comprising the secondary circulatory system in human body, play a multifaceted role in maintaining homeostasis among various tissues and organs.
Zhaoliang Hu +7 more
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Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms [PDF]
Nature Communications, 2018 VEGF-C is a key regulator of lymphatic development. Here, Zhang et al. show that while complete loss of its receptor VEGFR3 results in vessel hypoplasia, mosaic loss of VEGFR3 leads to hyperplasia through induction of cell proliferation in neighboringnon-
Yan Zhang +6 more
doaj +3 more sources
Biomechanical control of lymphatic vessel physiology and functions. [PDF]
Cell Mol Immunol, 2023 The ever-growing research on lymphatic biology has clearly identified lymphatic vessels as key players that maintain human health through their functional roles in tissue fluid homeostasis, immunosurveillance, lipid metabolism and inflammation.
Angeli V, Lim HY.
europepmc +2 more sources
Renal lymphatic vessel dynamics.
American Journal of Physiology-Renal Physiology, 2020 Similar to other organs, renal lymphatics remove excess fluid, solutes, and macromolecules from the renal interstitium. Given the kidney's unique role in maintaining body fluid homeostasis, renal lymphatics may be critical in this process.
Elaine L. Shelton +4 more
semanticscholar +4 more sources
Inhibiting corneal transplantation rejection via lymphatic vessel ligation in a novel murine model [PDF]
Scientific ReportsThe lymphatic system is a crucial contributor to allograft rejection after corneal transplantation. However, no surgical procedures for the central pathway where conjunctival lymphatic vessels converge have been investigated.
Ami Igarashi +4 more
doaj +2 more sources
BMC Cancer, 2017 Background Lymphatic vessel density and lymphovascular invasion are commonly assessed to identify the clinicopathological outcomes in breast cancer. However, the prognostic values of them on patients’ survival are still uncertain.
Song Zhang +5 more
doaj +2 more sources
Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2. [PDF]
Nature Communications, 2015 The lymphatic system maintains tissue fluid balance, and dysfunction of lymphatic vessels and valves causes human lymphedema syndromes. Yet, our knowledge of the molecular mechanisms underlying lymphatic vessel development is still limited. Here, we show
Adams, R.H. +12 more
core +3 more sources
Mechanical forces in lymphatic vessel development: Focus on transcriptional regulation [PDF]
Frontiers in Physiology, 2022 The lymphatic system is crucial for the maintenance of interstitial fluid and protein homeostasis. It has important roles in collecting excess plasma and interstitial fluid leaked from blood vessels, lipid absorption and transportation in the digestive ...
Naoto Ujiie, Tsutomu Kume
doaj +2 more sources
Hydrogen sulfide donor activates AKT-eNOS signaling and promotes lymphatic vessel formation. [PDF]
PLoS ONE, 2023 The lymphatic network is pivotal for various physiological functions in the human body. Accumulated evidence supports the role of therapeutic lymphangiogenesis in the treatment of several pathologies.
Ravi Varma Aithabathula +7 more
doaj +2 more sources