Results 11 to 20 of about 1,000,858 (371)

Pkd1 Regulates Lymphatic Vascular Morphogenesis during Development [PDF]

Cell Reports, 2014
Lymphatic vessels arise during development through sprouting of precursor cells from veins, which is regulated by known signaling and transcriptional mechanisms. The ongoing elaboration of vessels to form a network is less well understood.
Baptiste Coxam, Amélie Sabine, Neil I. Bower, Kelly A. Smith, Cathy Pichol-Thievend, Renae Skoczylas, Jonathan W. Astin, Emmanuelle Frampton, Muriel Jaquet, Philip S. Crosier, Robert G. Parton, Natasha L. Harvey, Tatiana V. Petrova, Stefan Schulte-Merker, Mathias Francois, Benjamin M. Hogan   +15 more
doaj   +5 more sources

Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2 [PDF]

Nature Communications, 2015
The lymphatic system maintains tissue fluid balance, and dysfunction of lymphatic vessels and valves causes human lymphedema syndromes. Yet, our knowledge of the molecular mechanisms underlying lymphatic vessel development is still limited. Here, we show
J. Liebl, Siwei Zhang, M. Moser, Yan Agalarov, Cansaran Saygili Demir, B. Hager, J. Bibb, R. Adams, F. Kiefer, N. Miura, T. Petrova, A. Vollmar, S. Zahler   +12 more
semanticscholar   +4 more sources

Blood and lymphatic vessel formation. [PDF]

Cold Spring Harbor Perspectives in Biology, 2015
Blood and lymphatic vessels deliver oxygen and nutrients, remove waste and CO2, and regulate interstitial pressure in tissues and organs. These vessels begin life early in embryogenesis using transcription factors and signaling pathways that regulate ...
V. Bautch, K. Caron
semanticscholar   +3 more sources

Lymphatic vessel network injury reduces local tumor control despite preservation of the tumor-draining lymph node [PDF]

Scientific Reports
The lymphatic system plays complex, often contradictory, roles in many cancers, including melanoma; these roles include contributions to tumor cell metastasis and immunosuppression in the tumor microenvironment as well as generation of antitumor immunity.
Lauren N. Liebman, Yang Shen, Zachary S. Buchwald, Zhanna Nepiyushchikh, Zhiming Qi, Andrés J. García, J. Brandon Dixon   +6 more
doaj   +2 more sources

Hemorrhage Into Lymphatic Vessels [PDF]

Military Medicine, 1953
Lothar Wirth
openalex   +4 more sources

Lymphatic Vessel Regression and Its Therapeutic Applications: Learning From Principles of Blood Vessel Regression

Frontiers in Physiology, 2022
Aberrant lymphatic system function has been increasingly implicated in pathologies such as lymphedema, organ transplant rejection, cardiovascular disease, obesity, and neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease ...
Faisal Masood, Rohan Bhattaram, Mark I. Rosenblatt, Andrius Kazlauskas, Jin-Hong Chang, Dimitri T. Azar   +5 more
doaj   +1 more source

Comparison of normal hindlimb lymphatic systems in rats with detours present after lymphatic flow blockage.

PLoS ONE, 2021
In the present study, we aimed to identify the normal hindlimb lymphatic systems in rats and compare them with the detours after lymphatic flow blockage.
Yuiko Suzuki, Yukari Nakajima, Toshio Nakatani, Mayumi Okuwa, Junko Sugama   +4 more
doaj   +1 more source

Investigating lymphangiogenesis in vitro and in vivo using engineered human lymphatic vessel networks

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Lymphatic vessel networks are important for various biological processes; thus, incorporating them into engineered constructs can have both research and clinical implications.
S. Landau, A. Newman, Shlomit Edri, I. Michael, S. Ben-Shaul, Y. Shandalov, Tom Ben-Arye, P. Kaur, M. Zheng, S. Levenberg   +9 more
semanticscholar   +1 more source

Loss of Primary Cilia Protein IFT20 Dysregulates Lymphatic Vessel Patterning in Development and Inflammation

Frontiers in Cell and Developmental Biology, 2021
Microenvironmental signals produced during development or inflammation stimulate lymphatic endothelial cells to undergo lymphangiogenesis, in which they sprout, proliferate, and migrate to expand the vascular network.
Delayna Paulson, Delayna Paulson, Rebecca Harms, Rebecca Harms, Cody Ward, Cody Ward, Mackenzie Latterell, Mackenzie Latterell, Gregory J. Pazour, Darci M. Fink, Darci M. Fink   +10 more
doaj   +1 more source

Lymphatic Collecting Vessel: New Perspectives on Mechanisms of Contractile Regulation and Potential Lymphatic Contractile Pathways to Target in Obesity and Metabolic Diseases

Frontiers in Pharmacology, 2022
Obesity and metabolic syndrome pose a significant risk for developing cardiovascular disease and remain a critical healthcare challenge. Given the lymphatic system’s role as a nexus for lipid absorption, immune cell trafficking, interstitial fluid and ...
Yang Lee, Scott D. Zawieja, Mariappan Muthuchamy   +2 more
doaj   +1 more source