Results 11 to 20 of about 923,689 (313)

Renal lymphatic vessel dynamics

American Journal of Physiology-Renal Physiology, 2020
Similar to other organs, renal lymphatics remove excess fluid, solutes, and macromolecules from the renal interstitium. Given the kidney’s unique role in maintaining body fluid homeostasis, renal lymphatics may be critical in this process. However, little is known regarding the pathways involved in renal lymphatic vessel function, and there are no ...
Haichun Yang, Haichun Yang, Jianyong Zhong, Jianyong Zhong, Michele M Salzman, Valentina Kon, Elaine L. Shelton, Elaine L. Shelton   +7 more
openaire   +5 more sources

High lymphatic vessel density and presence of lymphovascular invasion both predict poor prognosis in breast cancer

BMC Cancer, 2017
Background Lymphatic vessel density and lymphovascular invasion are commonly assessed to identify the clinicopathological outcomes in breast cancer. However, the prognostic values of them on patients’ survival are still uncertain.
Song Zhang, Dong Zhang, Mingfu Gong, Li Wen, Cuiwei Liao, Liguang Zou   +5 more
doaj   +2 more sources

Lymphatic vessel: Origin, heterogeneity, biological functions and therapeutic targets

Signal Transduction and Targeted Therapy
Lymphatic vessels, comprising the secondary circulatory system in human body, play a multifaceted role in maintaining homeostasis among various tissues and organs.
Zhaoliang Hu, Xushi Zhao, Zhonghua Wu, Bicheng Qu, Minxian Yuan, Yanan Xing, Yongxi Song, Zhenning Wang   +7 more
doaj   +2 more sources

Blood and Lymphatic Vessel Formation [PDF]

Cold Spring Harbor Perspectives in Biology, 2015
Blood and lymphatic vessels deliver oxygen and nutrients, remove waste and CO2, and regulate interstitial pressure in tissues and organs. These vessels begin life early in embryogenesis using transcription factors and signaling pathways that regulate differentiation, morphogenesis, and proliferation.
Kathleen M. Caron, Victoria L. Bautch
openaire   +3 more sources

Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms

Nature Communications, 2018
VEGF-C is a key regulator of lymphatic development. Here, Zhang et al. show that while complete loss of its receptor VEGFR3 results in vessel hypoplasia, mosaic loss of VEGFR3 leads to hyperplasia through induction of cell proliferation in neighboringnon-
Yan Zhang, Maria H. Ulvmar, Lukas Stanczuk, Ines Martinez-Corral, Maike Frye, Kari Alitalo, Taija Mäkinen   +6 more
doaj   +2 more sources

Biomechanical control of lymphatic vessel physiology and functions

Cellular & Molecular Immunology, 2023
The ever-growing research on lymphatic biology has clearly identified lymphatic vessels as key players that maintain human health through their functional roles in tissue fluid homeostasis, immunosurveillance, lipid metabolism and inflammation.
V. Angeli, H. Lim
semanticscholar   +1 more source

Investigating lymphangiogenesis in vitro and in vivo using engineered human lymphatic vessel networks

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Lymphatic vessel networks are important for various biological processes; thus, incorporating them into engineered constructs can have both research and clinical implications.
S. Landau, A. Newman, Shlomit Edri, I. Michael, S. Ben-Shaul, Y. Shandalov, Tom Ben-Arye, P. Kaur, M. Zheng, S. Levenberg   +9 more
semanticscholar   +1 more source

A bioengineered lymphatic vessel model for studying lymphatic endothelial cell‐cell junction and barrier function

Microcirculation, 2021
Lymphatic vessels (LVs) maintain fluid homeostasis by draining interstitial fluid. A failure in lymphatic drainage triggers lymphatic diseases such as lymphedema.
A. Henderson, Isabelle S. Ilan, Esak Lee
semanticscholar   +1 more source

Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart

Development, 2020
Macrophages are components of the innate immune system with key roles in tissue inflammation and repair. It is now evident that macrophages also support organogenesis, but few studies have characterized their identity, ontogeny and function during heart ...
T. Cahill, Xin Sun, Christophe Ravaud, Cristina Villa del Campo, K. Klaourakis, Irina-Elena Lupu, Allegra M. Lord, Cathy Browne, S. Jacobsen, D. Greaves, D. Jackson, S. Cowley, W. James, R. Choudhury, J. Vieira, P. Riley   +15 more
semanticscholar   +1 more source

Pathogenic Exploitation of Lymphatic Vessels

Cells, 2022
Lymphatic vessels provide a critical line of communication between peripheral tissues and their draining lymph nodes, which is necessary for robust immune responses against infectious agents. At the same time, lymphatics help shape the nature and kinetics of immune responses to ensure resolution, limit tissue damage, and prevent autoimmune responses. A
Alexandra I. Magold, Melody A. Swartz
openaire   +3 more sources