Results 11 to 20 of about 1,026,018 (392)

Loss of Primary Cilia Protein IFT20 Dysregulates Lymphatic Vessel Patterning in Development and Inflammation

Frontiers in Cell and Developmental Biology, 2021
Microenvironmental signals produced during development or inflammation stimulate lymphatic endothelial cells to undergo lymphangiogenesis, in which they sprout, proliferate, and migrate to expand the vascular network.
Delayna Paulson, Delayna Paulson, Rebecca Harms, Rebecca Harms, Cody Ward, Cody Ward, Mackenzie Latterell, Mackenzie Latterell, Gregory J. Pazour, Darci M. Fink, Darci M. Fink   +10 more
doaj   +2 more sources

Impaired meningeal lymphatic vessel development worsens stroke outcome [PDF]

Journal of Cerebral Blood Flow and Metabolism, 2019
The discovery of meningeal lymphatic vessels (LVs) has sparked interest in identifying their role in diseases of the central nervous system. Similar to peripheral LVs, meningeal LVs depend on vascular endothelial growth factor receptor-3 (VEGFR3 ...
Pavel Yanev, Katherine Poinsatte, Devon Hominick, Noor Khurana, Kielen R. Zuurbier, M. Berndt, E. Plautz, M. Dellinger, Ann M. Stowe   +8 more
semanticscholar   +2 more sources

Pathogenic Exploitation of Lymphatic Vessels [PDF]

Cells, 2022
Lymphatic vessels provide a critical line of communication between peripheral tissues and their draining lymph nodes, which is necessary for robust immune responses against infectious agents. At the same time, lymphatics help shape the nature and kinetics of immune responses to ensure resolution, limit tissue damage, and prevent autoimmune responses. A
Alexandra I. Magold, Melody A. Swartz
openaire   +4 more sources

Lymphatic vessel network injury reduces local tumor control despite preservation of the tumor-draining lymph node [PDF]

Scientific Reports
The lymphatic system plays complex, often contradictory, roles in many cancers, including melanoma; these roles include contributions to tumor cell metastasis and immunosuppression in the tumor microenvironment as well as generation of antitumor immunity.
Lauren N. Liebman, Yang Shen, Zachary S. Buchwald, Zhanna Nepiyushchikh, Zhiming Qi, Andrés J. García, J. Brandon Dixon   +6 more
doaj   +2 more sources

Lymphatic Vessel Regression and Its Therapeutic Applications: Learning From Principles of Blood Vessel Regression

Frontiers in Physiology, 2022
Aberrant lymphatic system function has been increasingly implicated in pathologies such as lymphedema, organ transplant rejection, cardiovascular disease, obesity, and neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease ...
Faisal Masood, Rohan Bhattaram, Mark I. Rosenblatt, Andrius Kazlauskas, Jin-Hong Chang, Dimitri T. Azar   +5 more
doaj   +1 more source

Comparison of normal hindlimb lymphatic systems in rats with detours present after lymphatic flow blockage.

PLoS ONE, 2021
In the present study, we aimed to identify the normal hindlimb lymphatic systems in rats and compare them with the detours after lymphatic flow blockage.
Yuiko Suzuki, Yukari Nakajima, Toshio Nakatani, Mayumi Okuwa, Junko Sugama   +4 more
doaj   +1 more source

The Underlying Role of the Glymphatic System and Meningeal Lymphatic Vessels in Cerebral Small Vessel Disease

Biomolecules, 2022
There is a growing prevalence of vascular cognitive impairment (VCI) worldwide, and most research has suggested that cerebral small vessel disease (CSVD) is the main contributor to VCI. Several potential physiopathologic mechanisms have been proven to be
Yu-Syuan Tian, Mengxi Zhao, Yiyi Chen, Mo Yang, Yilong Wang   +4 more
semanticscholar   +1 more source

A bioengineered lymphatic vessel model for studying lymphatic endothelial cell‐cell junction and barrier function

Microcirculation, 2021
Lymphatic vessels (LVs) maintain fluid homeostasis by draining interstitial fluid. A failure in lymphatic drainage triggers lymphatic diseases such as lymphedema.
A. Henderson, Isabelle S. Ilan, Esak Lee
semanticscholar   +1 more source

Lymphatic Collecting Vessel: New Perspectives on Mechanisms of Contractile Regulation and Potential Lymphatic Contractile Pathways to Target in Obesity and Metabolic Diseases

Frontiers in Pharmacology, 2022
Obesity and metabolic syndrome pose a significant risk for developing cardiovascular disease and remain a critical healthcare challenge. Given the lymphatic system’s role as a nexus for lipid absorption, immune cell trafficking, interstitial fluid and ...
Yang Lee, Scott D. Zawieja, Mariappan Muthuchamy   +2 more
doaj   +1 more source

Investigating lymphangiogenesis in vitro and in vivo using engineered human lymphatic vessel networks

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Lymphatic vessel networks are important for various biological processes; thus, incorporating them into engineered constructs can have both research and clinical implications.
Shira Landau, A. Newman, Shlomit Edri, I. Michael, Shahar Ben-Shaul, Y. Shandalov, Tom Ben-Arye, P. Kaur, M. Zheng, S. Levenberg   +9 more
semanticscholar   +1 more source