Results 61 to 70 of about 923,689 (313)

An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel Formation

Circulation Research, 2017
Rationale: Lymphatic vessel formation and function constitutes a physiologically and pathophysiologically important process, but its genetic control is not well understood.
Terhi Karpanen, Y. Padberg, S. A. van de Pavert, Cathrin Dierkes, Nanami Morooka, J. Peterson-Maduro, Glenn van de Hoek, Max Adrian, N. Mochizuki, K. Sekiguchi, F. Kiefer, Dörte Schulte, S. Schulte-Merker   +12 more
semanticscholar   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Prognostic factors in conversion surgery following nab‐paclitaxel with gemcitabine and subsequent chemoradiotherapy for unresectable locally advanced pancreatic cancer: Results of a dual‐center study

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 157-166, January 2023., 2023
For radical surgery after induction gemcitabine along with nab‐paclitaxel and subsequent chemoradiotherapy for unresectable locally advanced pancreatic ductal adenocarcinoma, CA19‐9 normalization and maintenance of good nutritional status during treatment until surgery were important for prolonged prognosis.
Takamichi Igarashi, Suguru Yamada, Yui Hoshino, Kenta Murotani, Hayato Baba, Hideki Takami, Isaku Yoshioka, Kazuto Shibuya, Yasuhiro Kodera, Tsutomu Fujii   +9 more
wiley   +1 more source

EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity

eLife, 2020
Endothelial integrity is vital for homeostasis and adjusted to tissue demands. Although fluid uptake by lymphatic capillaries is a critical attribute of the lymphatic vasculature, the barrier function of collecting lymphatic vessels is also important by ...
Maike Frye, Simon Stritt, Henrik Ortsäter, Magda Hernandez Vasquez, Mika Kaakinen, Andres Vicente, John Wiseman, Lauri Eklund, Jorge L Martínez-Torrecuadrada, Dietmar Vestweber, Taija Mäkinen   +10 more
doaj   +1 more source

Lymphatic Endothelial Markers and Tumor Lymphangiogenesis Assessment in Human Breast Cancer

Diagnostics, 2021
Metastasis via lymphatic vessels or blood vessels is the leading cause of death for breast cancer, and lymphangiogenesis and angiogenesis are critical prerequisites for the tumor invasion–metastasis cascade.
Jia-Mei Chen, Bo Luo, Ru Ma, Xi-Xi Luo, Yong-Shun Chen, Yan Li   +5 more
doaj   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Pkd1 Regulates Lymphatic Vascular Morphogenesis during Development

Cell Reports, 2014
Lymphatic vessels arise during development through sprouting of precursor cells from veins, which is regulated by known signaling and transcriptional mechanisms. The ongoing elaboration of vessels to form a network is less well understood.
Baptiste Coxam, Amélie Sabine, Neil I. Bower, Kelly A. Smith, Cathy Pichol-Thievend, Renae Skoczylas, Jonathan W. Astin, Emmanuelle Frampton, Muriel Jaquet, Philip S. Crosier, Robert G. Parton, Natasha L. Harvey, Tatiana V. Petrova, Stefan Schulte-Merker, Mathias Francois, Benjamin M. Hogan   +15 more
doaj   +1 more source

Supermicrosurgical deep lymphatic vessel‐to‐venous anastomosis for a breast cancer‐related arm lymphedema with severe sclerosis of superficial lymphatic vessels

Microsurgery, 2017
Lymphatic supermicrosurgery or supermicrosurgical lymphaticovenular anastomosis (LVA) is becoming popular for the treatment of compression‐refractory upper extremity lymphedema (UEL) with its effectiveness and minimally invasiveness. In conventional LVA,
Takumi Yamamoto, N. Yamamoto, A. Hayashi, I. Koshima   +3 more
semanticscholar   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling

Circulation Research, 2017
Rationale: Lymphatic vasculature constitutes a second vascular system essential for immune surveillance and tissue fluid homeostasis. Maturation of the hierarchical vascular structure, with a highly branched network of capillaries and ducts, is crucial ...
Nanami Morooka, S. Futaki, Ryoko Sato-Nishiuchi, M. Nishino, Yuta Totani, Chisei Shimono, Itsuko Nakano, Hiroyuki Nakajima, N. Mochizuki, K. Sekiguchi   +9 more
semanticscholar   +1 more source