Results 41 to 50 of about 531,069 (346)

Biological aspects of mTOR in leukemia [PDF]

, 2018
The mammalian target of rapamycin (mTOR) is a central processor of intra-and extracellular signals, regulating many fundamental cellular processes such as metabolism, growth, proliferation, and survival.
Bianchi, Mp, Gianfelici, V, Mirabilii, S, Piedimonte, M, Ricciardi, Mr, Tafuri, A.   +5 more
core   +1 more source

T-Lymphoblastic Leukemia/Lymphoma [PDF]

American Journal of Clinical Pathology, 2015
To review important concepts from the 2013 Society for Hematopathology/European Association for Haematopathology Workshop session on T-acute lymphoblastic leukemia/T-lymphoblastic lymphoma (T-ALL/T-LBL).Twenty-one submitted cases are reviewed and summarized, with emphasis on key diagnostic or biologic points, and supplemented with relevant literature ...
M James, You, L Jeffrey, Medeiros, Eric D, Hsi   +2 more
openaire   +2 more sources

Tailoring CD19xCD3-DART exposure enhances T-cells to eradication of B-cell neoplasms. [PDF]

, 2018
Many patients with B-cell malignancies can be successfully treated, although tumor eradication is rarely achieved. T-cell-directed killing of tumor cells using engineered T-cells or bispecific antibodies is a promising approach for the treatment of ...
Aliberti S, Bareja R, Bonvini E, Bruna R, Brusa D, Chiaretti S, Chichili GR, Cignetti A, Circosta P, Deaglio S, Elemento O, Elia AR, Foà R, Giacomo FD, Gottardi D, Guarini AR, Inghirami G., Johnson S, Kyriakides PW, Landra I, Machiorlatti R, Massaia M, Monteleone E, Moore PA, Todaro M   +24 more
core   +1 more source

A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era. Selecting cases, matching clinical benefit. A position paper from the Italian Group of Haematopathology (G.I.E.) [PDF]

, 2019
An accurate diagnosis of clinically distinct subgroups of aggressive mature B cell lymphomas is crucial for the choice of proper treatment. Presently, precise recognition of these disorders relies on the combination of morphological, immunophenotypical ...
Agostinelli, C., Ambrosio, M. R., Ascani, S., Carbone, A., Di Napoli, A., Facchetti, F., Lazzi, S., Leoncini, L., Lucioni, M., Novero, D., Paulli, M., Pileri, S., Ponzoni, M., Remotti, D., Ruco, L., Sabattini, E., Tripodo, C., Zamo, A.   +17 more
core   +2 more sources

Detection of novel fusion-transcripts by RNA-Seq in T-cell lymphoblastic lymphoma

Scientific Reports, 2019
Fusions transcripts have been proven to be strong drivers for neoplasia-associated mutations, although their incidence in T-cell lymphoblastic lymphoma needs to be determined yet.
P. López-Nieva, P. Fernández-Navarro, Osvaldo Graña-Castro, Eduardo Andrés-León, Javier Santos, M. Villa-Morales, M. A. Cobos-Fernández, Laura González-Sánchez, Marcos Malumbres, María Salazar-Roa, J. Fernández-Piqueras   +10 more
semanticscholar   +1 more source

"Society of Hematologic Oncology (SOHO) State of the Art Updates and Next Questions"-Treatment of ALL. [PDF]

, 2018
The outcome of adult acute lymphoblastic leukemia (ALL) has substantially improved by adopting pediatric-inspired regimens, and approximately half of the patients are nowadays cured.
Chiaretti, S, Hoelzer, D, Jabbour, E
core   +1 more source

S194-P-FADD as a marker of aggressiveness and poor prognosis in human T-cell lymphoblastic lymphoma.

Carcinogenesis, 2019
T-cell lymphoblastic lymphoma is a haematological disease with an urgent need for reliable prognostic biomarkers that allow therapeutic stratification and dose adjustment. The scarcity of human samples is responsible for the delayed progress in the study
J. L. Marín-Rubio, E. Pérez-Gómez, J. Fernández-Piqueras, M. Villa-Morales   +3 more
semanticscholar   +1 more source

Transformation of acute lymphoblastic leukemia with a precursor B-cell immunophenotype to burkitt’s lymphoma: A case report [PDF]

Caspian Journal of Internal Medicine, 2023
Background: As a new point, some very rare features can be revealed as initial diagnosis of acute lymphoblastic leukemia (ALL) without any evidence of lymphoma-like behavior which after initial recovery, presents with new evidence of lymphoma.
Masoumeh Jafari, Shahla Ansari Damavandi, Forugh Charmduzi   +2 more
doaj  

Multifocal precursor B-cell lymphoblastic lymphoma in an infant with cardiac involvement: A case report

Radiology Case Reports, 2021
Lymphoma with cardiac involvement is a high-risk lesion, especially in children. We report a rare clinical case of multifocal precursor B-cell lymphoblastic lymphoma in a child with cardiac involvement.
Tran Phan Ninh, MD, PhD, Nguyen Minh Duc, MD, Nguyen Ngoc Trung, MD, PhD, Le Anh Duc, MD, PhD, Doan-Van Ngoc, MD, PhD, Thieu-Thi Tra My, MD, Nguyen-Van Sang, MD, PhD, Pham Minh Thong, MD, PhD   +7 more
doaj   +1 more source

Sinonasal Lymphoma Presenting as a Probable Sanctuary Site for Relapsed B Acute Lymphoblastic Leukaemia: A Case Report and Review of the Literature

Case Reports in Hematology, 2015
Sinonasal lymphoma is a non-Hodgkin lymphoma (NHL) representing 1.5% of all lymphomas. It presents as an unremitting ulceration with progressive destruction of midline sinonasal and surrounding structures. Poor prognosis warrants early treatment although
W. Y. Lim, R. Care, M. Lau, S. Chiruka, P. J. D. Dawes   +4 more
doaj   +1 more source