Results 91 to 100 of about 399,802 (272)

Immune Evasion through Competitive Inhibition: the Shielding Effect of non-Stem Cancer Cells [PDF]

arXiv, 2014
It has been recently proposed that the two "emerging" hallmarks of cancer, namely altered glucose metabolism and immune evasion, may in fact be fundamentally linked (Kareva and Hahnfeldt, 2013). This connection comes from up-regulation of glycolysis by tumor cells, which can lead to active competition for resources in the tumor microenvironment between
arxiv  

Effects of Euphorbia milii latex on mitogen-induced lymphocyte proliferation

Revista Brasileira de Plantas Medicinais, 2014
The crude latex of "Crown-of-Thorns" (Euphorbia milii var hislopii, syn E.splendens) is a potent plant molluscicide. For this reason, toxicological studies have been performed to evaluate the health risks posed by its use in schistosomiasis control ...
I.F. Delgado, F.J.R. Paumgartten
doaj  

Cross-company evaluation of the human lymphocyte activation assay

Journal of Immunotoxicology, 2020
Nonclinical immunotoxicity evaluation is an important component of safety assessment for pharmaceuticals. One in vitro assay that can be applied in a weight of evidence assessment is the human lymphocyte activation (HuLA) assay, an antigen recall assay ...
Mark Collinge, Patricia Schneider, Dingzhou Li, Stanley Parish, Carolyne Dumont, Wendy Freebern, Joseph Ghanime, Fanny Guimont-Derochers, Anja Langenkamp, Jose Lebron, Nianyu Li, Celine Marban, Lisa Plitnick, Jennifer Wheeler   +13 more
doaj   +1 more source

CD44v, S1PR1, HER3, MET and cancer‐associated amino acid transporters are promising targets for the pancreatic cancers characterized using mAb

FEBS Open Bio, EarlyView.
Novel mAbs could detect cancer‐associated membrane proteins on various type of pancreatic ductal adenocarcinomas (PDAC) by flow cytometry with viable PDAC cells and by immunohistochemistry with PDAC tissues. Results of protein expression were substantiated by mRNA expression by The Cancer Genome Atlas.
Takashi Nakano, Kouki Okita, Shogo Okazaki, Soshi Yoshimoto, Sachiko Masuko, Hideki Yagi, Kazunori Kato, Yoshihisa Tomioka, Kenichi Imai, Yoichi Hamada, Kazue Masuko, Kayoko Shimada‐Takaura, Noriaki Nagai, Hideyuki Saya, Tomio Arai, Toshiyuki Ishiwata, Takashi Masuko   +16 more
wiley   +1 more source

n-3 PUFA improves fatty acid composition, prevents palmitate-induced apoptosis, and differentially modifies B cell cytokine secretion in vitro and ex vivo

Journal of Lipid Research, 2010
n-3 polyunsaturated fatty acids (PUFAs) modify T-cell activation, in part by remodeling lipid composition; however, the relationship between n-3 PUFA and B-cell activation is unknown.
Benjamin Drew Rockett, Muhammad Salameh, Kristen Carraway, Kaitlin Morrison, Saame Raza Shaikh   +4 more
doaj  

Changes in the expression of molecular markers of peripheral blood lymphocyte activation in patients with small (T1) choroidal melanoma after transpupillary thermotherapy

Journal of Ophthalmology, 2019
Background: Expression of some functional molecules on peripheral blood lymphocytes is critically important for the development of adequate antitumor response.
I.V. Tsukanova, S.I. Poliakova, L.M. Velichko, O.V. Bogdanova   +3 more
doaj   +1 more source

Comparative activity of dimethyl fumarate derivative IDMF in three models relevant to multiple sclerosis and psoriasis

FEBS Open Bio, EarlyView.
IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He, Guiyi Gong, Geovani Quijas, Simon Ming‐Yuen Lee, Ratan K. Chaudhuri, Krzysztof Bojanowski   +5 more
wiley   +1 more source

Dynamic model of HIV infection with immune system response of T-lymphocytes, B-cells and dendritic cells: a review [PDF]

arXiv, 2020
A dynamic model of non-lineal time-dependent ordinary differential equations (ODE) has been applied to the interactions of a HIV infection with the immune system cells. This model has been simplified into two compartments: lymph node and peripheral blood.
arxiv  

The serial engagement model seventeen years after: from TCR triggering to immunotherapy

Frontiers in Immunology, 2012
More than fifteen years ago the serial engagement model was proposed as an attempt to solve the low affinity/high sensitivity paradox of TCR antigen recognition.
Salvatore eValitutti, Salvatore eValitutti, Salvatore eValitutti   +2 more
doaj   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source