Results 121 to 130 of about 399,802 (272)

Short‐Chain Fatty Acids Modulate Anti‐ROR1 CAR T‐Cell Function and Exhaustion in an Intestinal Adenocarcinoma‐on‐Chip Model

Advanced Healthcare Materials, EarlyView.
Short‐chain fatty acids modulate anti‐ROR1 chimeric antigen receptor (CAR) T‐cell function in an intestinal adenocarcinoma‐on‐chip model. Butyrate and propionate reduce cytotoxicity, cytokine release, and infiltration by inducing a regulatory T‐cell phenotype and T‐cell exhaustion via histone deacetylase inhibition.
Valentin D. Wegner, Adrian Feile, Miriam Alb, Michael Hudecek, Philip Hewitt, Alexander S. Mosig   +5 more
wiley   +1 more source

Hypertension and immune activation in antiretroviral therapy naïve people living with human immunodeficiency virus

BMC Infectious Diseases
Background The pathogenesis of hypertension (HTN) in people living with HIV/AIDS (PLHIV) is complex and remains not fully understood. Chronic immune activation (IA) is postulated to be one of the culprits.
Tosi M. Mwakyandile, Grace A. Shayo, Philip G. Sasi, Ferdinand M. Mugusi, Godfrey Barabona, Takamasa Ueno, Eligius F. Lyamuya   +6 more
doaj   +1 more source

Superoxide dismutase activity of T lymphocytes and non‐T lymphocytes [PDF]

FEBS Letters, 1979
Susumu Okahata, Yohnosuke Kobayashi, Tomofusa Usui, Kyoji Tanabe, Takashi Sakano   +4 more
openaire   +3 more sources

Imine Crosslinked, Injectable, and Self‐Healing Fucoidan Hydrogel with Immunomodulatory Properties

Advanced Healthcare Materials, EarlyView.
This study develops an injectable fucoidan‐based hydrogel with tunable properties for tissue engineering. By oxidizing fucoidan (OFu) to introduce aldehydes, imine crosslinks are formed with amine‐containing polymers, enabling self‐healing, injectability, and long‐term stability (≥28 days). The OFu‐gelatin hydrogel demonstrated biocompatibility, immune‐
Asma Talib Qureshi, Shajia Afrin, Saad Asim, Muhammad Rizwan   +3 more
wiley   +1 more source

Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response

Advanced Healthcare Materials, EarlyView.
In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim, Jin Woong Lee, Piper A. Rawding, Mari Iida, Carter Kim, Kourtney L. Kostecki, Michael J. Poellmann, Bridget Crossman, Ashley S. Liu, YoungSoo Kim, Deric L. Wheeler, Seungpyo Hong   +11 more
wiley   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Lymphocyte activation gene 3 is increased and affects cytokine production in rheumatoid arthritis. [PDF]

Arthritis Res Ther, 2023
Pedersen JM, Hansen AS, Skejø C, Juul-Madsen K, Junker P, Hørslev-Petersen K, Hetland ML, Stengaard-Pedersen K, Østergaard M, Møller BK, Dreyer L, Hauge EM, Hvid M, Greisen S, Deleuran B.   +14 more
europepmc   +1 more source

Carbon Dot‐Linked Hydrogel for TAMs Transform: Spatiotemporal Manipulation to Reshape Tumor Microenvironment

Advanced Materials, EarlyView.
The CDs crosslinked egg white hydrogel loaded with lipopolysaccharide (LPS) and CA170 (TTF‐L‐C) can realize spatiotemporal tumor‐associated macrophages (TAMs) transformation from multi‐level dimensions, including spatial recruitment, cell phenotype reprogramming, and immune checkpoint molecule blockade.
Lingyun Li, Jun Wu, Xue Wu, Zhenjian Li, Xianming Zhang, Zekun Yan, Yingqi Liang, Caishi Huang, Songnan Qu   +8 more
wiley   +1 more source

Exploring the putative role of PRDM1 and PRDM2 transcripts as mediators of T lymphocyte activation. [PDF]

J Transl Med, 2023
Di Zazzo E, Rienzo M, Casamassimi A, De Rosa C, Medici N, Gazzerro P, Bifulco M, Abbondanza C.   +7 more
europepmc   +1 more source

Autologous Peripheral Vγ9Vδ2 T Cell Synergizes with αβ T Cell Through Antigen Presentation and BTN3A1 Blockade in Immunotherapy of Cervical Cancer

Advanced Science, EarlyView.
This study provides proof‐of‐concept evidence showing that through direct killing, antigen presentation, and competitively binding to BTN3A1, Vγ9Vδ2 T cells amplified from cervical cancer (CC) patients can synergize with αβ T cells to exert anti‐CC function both in vitro and in vivo.
Min Wu, Jian Liu, Liting Liu, Yifan Yang, Hong Liu, Long Yu, Haihong Zeng, Shuo Yuan, Ruiyi Xu, Hangyu Liu, Han Jiang, Shen Qu, Liming Wang, Ying Chen, Jingyu Wang, Yuwei Zhang, Shan He, Ling Feng, Junyan Han, Wanjiang Zeng, Hui Wang, Yafei Huang   +21 more
wiley   +1 more source