Results 131 to 140 of about 349,873 (260)

Pan cohort immune biomarker of CD8 lymphocyte activation enabling HGSOC outcome prediction and treatment response. [PDF]

Discov Oncol
Liu X, Zhang Z, Wang B, Qin L, Fan N, Wang R, Yu X, Han Q, Lu Z, Kikete S, Shi F, Chu C, Zhang Y, Niu L, Wei R, Wu J, Li X.   +16 more
europepmc   +1 more source

Prognostic significance of Lymphocyte-activation gene 3 (LAG3) in patients with solid tumors: a systematic review, meta-analysis and pan-cancer analysis. [PDF]

Cancer Cell Int, 2023
Li R, Qiu J, Zhang Z, Qu C, Tang Z, Yu W, Tian Y, Tian H.   +7 more
europepmc   +1 more source

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Lymphocyte Activation Gene 3 Regulation of Profibrotic Cytokines and Type I Collagen Production in Patients With Systemic Sclerosis. [PDF]

ACR Open Rheumatol
Aspari M, Greisen S, Hvid M, Ong VH, Denton CP, Abraham D, Deleuran B.   +6 more
europepmc   +1 more source

Discovery of First-in-Class Small Molecule Inhibitors of Lymphocyte Activation Gene 3 (LAG-3). [PDF]

ACS Med Chem Lett, 2023
Abdel-Rahman SA, Rehman AU, Gabr MT.
europepmc   +1 more source

Platelet-lymphocyte cross-talk in atherogenesis : experimental studies on platelet-regulated lymphocyte adhesion and CD4+ T cell activation [Elektronisk resurs]

, 2014
Atherosclerosis is an inflammatory and thrombotic disease. Platelets and lymphocytes, especially CD4+ T cells, are indispensable players during the initiation and progression of atherosclerotic lesion formation.
Linjing, Z,
core  

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source

A Peptide Inhibitor of Lymphocyte Activation Gene-3 Interaction with Fibrinogen-like Protein 1 Synergizes with Programmed Death-Ligand 1 Blockade to Restore T Cell Activity and Inhibit Tumor Growth. [PDF]

Biomater Res
Lee SM, Gurung S, Park MS, Vadevoo SMP, Gunassekaran GR, Kim MJ, Kim SH, Kim HJ, Park EJ, Lee S, Im W, Kim S, Lee B.   +12 more
europepmc   +1 more source

The relationship between soluble lymphocyte activation gene-3 and coronary artery disease. [PDF]

Front Cardiovasc Med, 2022
Xiong X, Duan Z, Zhou H, Niu L, Luo Z, Li W.   +5 more
europepmc   +1 more source

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source