Results 121 to 130 of about 349,873 (260)

Fianlimab, a human lymphocyte activation gene-3 monoclonal antibody, in combination with cemiplimab: Tumor-specific expansion cohorts in advanced malignancies. [PDF]

Cancer
Kim TM, Williamson SK, Papadopoulos KP, Hamid O, Dy GK, McDermott R, Birnbaum A, Kaczmar JM, Lakhani N, Rischin D, Sarker D, Dowlati A, Zhu XH, Malhotra J, Pouliot JF, Mani J, Brennan L, Fang F, Chen S, Salvati M, Lowy I, Khaled A, Lewis KD, Kroog G, Fury MG, Cho BC.   +25 more
europepmc   +1 more source

Exploring the putative role of PRDM1 and PRDM2 transcripts as mediators of T lymphocyte activation. [PDF]

J Transl Med, 2023
Di Zazzo E, Rienzo M, Casamassimi A, De Rosa C, Medici N, Gazzerro P, Bifulco M, Abbondanza C.   +7 more
europepmc   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

P2RY13+ dendritic cells correlate with enhanced antigen presentation and lymphocyte activation in lung adenocarcinoma. [PDF]

Front Med (Lausanne)
Lan C, Zhong J, Che S.
europepmc   +1 more source

Water channel aquaporin 4 is required for T cell receptor mediated lymphocyte activation. [PDF]

J Leukoc Biol, 2023
Nicosia M, Lee J, Beavers A, Kish D, Farr GW, McGuirk PR, Pelletier MF, Lathia JD, Fairchild RL, Valujskikh A.   +9 more
europepmc   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Expression and prognostic importance of lymphocyte activation gene 3 and CD73 in advanced or metastatic hepatocellular carcinoma. [PDF]

J Int Med Res
Ayhan M, Dogan A, Keser SH, Başak K, Akdeniz N, Atci MM, Erhan SS, Arikan R, Celikel C, Turan N, Yıldırım ME, Odabas H, Yıldırım S, Laçin Ş, Kostek O.   +14 more
europepmc   +1 more source

The Polyamine Putrescine Is a Positive Regulator of Group 3 Innate Lymphocyte Activation. [PDF]

Immunohorizons, 2023
Sah P, Zenewicz LA.
europepmc   +1 more source

Disease progression in Human Immunodeficiency Virus type 1 infected viraemic controllers

, 2012
PhDBackground: The mechanism of CD4+ T-cell decline in Human Immunodeficiency Virus-1 (HIV-1) infection is unclear, but the association with plasma HIV-1 RNA-load suggests viral replication is involved.
Groves, Katherine Claire
core  

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source