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The Activation of T Lymphocytes
Rheumatic Disease Clinics of North America, 1987The events involved in T cell activation are initiated at the cell surface by the interaction of ligands with specific cell surface receptors on the T cell. Central to antigen-induced activation is the CD3/Ti complex, a complex multi-chain receptor responsible for antigen/MHC recognition and signal transduction. Triggering the CD3/Ti complex results in
Gary A. Koretzky +3 more
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Migration of Activated Lymphocytes [PDF]
, 1993 When lymphocytes leave the primary lymphoid organs as mature but naive cells, they enter the recirculating pool, moving continuously from the blood into the secondary lymphoid organs, spleen, lymph nodes and Peyer’s patches, from which they return, directly or via efferent lymph, back to the blood (Gowans and Knight 1964).
S. Rebstock, A. Hamann
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Metabolism of activated T lymphocytes
Current Opinion in Immunology, 2014Activated T cells undergo metabolic reprogramming which promotes glycolytic flux and lactate production as well as elevated production of lipids, proteins, nucleic acids and other carbohydrates (i.e. induction of biomass) even in the presence of oxygen.
Jason A Maciolek +2 more
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Cytotoxic Activity of Lymphocytes
The Journal of Immunology, 1972Abstract Antibody to human lymphotoxin was elicited in rabbits immunized with partially purified supernatants of human spleen cells stimulated by phytohemagglutinin; Anti-LT activity, assayed by neutralizing soluble LT toxicity to indicator mouse L cells, is confined to the immunoglobulin fraction of the serum; it cannot be removed by ...
Sharyn M Walker, Zoltan J Lucas
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Calcium and lymphocyte activation
Cellular Immunology, 1976Abstract The role of ionized calcium in the early phases of activation of human peripheral blood lymphocytes was evaluated by stimulating the cells with a calcium ionophore A23187 (Lilly) or with mitogenic lections over a broad range of extracellular calcium concentrations ( 1000 μ M ).
Christine M. Parker +2 more
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The Activation of Fetal Lymphocytes
Scandinavian Journal of Haematology, 1973Fetal lymphocytes from the cord blood of normal full‐term fetuses can be stimulated in vitro by PHA to transformation and mitotic division. The reaction kinetics differ from those of adult cells, in that the minimum G1 period is about 4 h shorter. However, the cord blood also contains a small number of lymphocytes, which enter the S period very soon ...
Valdemar Skoog +2 more
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1987
The T lymphocyte receptor for antigen and histocompatibility molecules is a molecular complex comprised of five polypeptide chains. Both the 49KD alpha and 43KD beta chains are immunoglobulin-like and thus contain variable domains responsible for ligand binding.
Hsiu-Ching Chang +5 more
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The T lymphocyte receptor for antigen and histocompatibility molecules is a molecular complex comprised of five polypeptide chains. Both the 49KD alpha and 43KD beta chains are immunoglobulin-like and thus contain variable domains responsible for ligand binding.
Hsiu-Ching Chang +5 more
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T lymphocyte activation signals.
Ciba Foundation symposium, 1992Activation of T lymphocytes results in immediate biochemical changes including increases in intracellular calcium levels, activation of protein kinase C (PKC) and changes in tyrosine phosphorylation. In T cells recent studies have indicated that activation of the guanine nucleotide-binding proteins p21ras is mediated by PKC, which suggests that the ...
Cantrell, D. A. +4 more
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T Lymphocyte Activation in Patients with Active Tuberculosis
American Review of Respiratory Disease, 1991Soluble interleukin-2 receptor (sIL-2R) is a marker of T lymphocyte activation. We measured the amount of serum sIL-2R in 35 patients with active tuberculosis before the initiation of antituberculous treatment. Twenty had pulmonary parenchymal lesion, 8 had tuberculous pleural effusion, and 7 had tuberculous lymphadenitis.
Leung, JCK, Lai, KN, Lai, CKW, Chan, CHS
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Raman micro-spectroscopy tracing human lymphocyte activation.
In Analysis, 2013The activation of lymphocytes occurs when they are exposed to viruses or other foreign antigens. The aim of this work was to verify if Raman spectroscopy can be used to screen the activation of lymphocytes during viral infection. There are distinct peaks
Aleksandra Wesełucha-Birczyńska +3 more
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