Results 31 to 40 of about 168,958 (281)

CTL Attenuation Regulated by PS1 in Cancer-Associated Fibroblast

Frontiers in Immunology, 2020
Objective: Cancer-associated fibroblasts (CAFs) were associated with tumor progression in the tumor microenvironment (TME). However, their immunosuppressive roles in protecting cancer cells from the attack by cytotoxic T lymphocytes (CTLs) are not fully ...
Hongyu Zhang, Rong Jiang, Jinhua Zhou, Juan Wang, Yuejuan Xu, He Zhang, Yanzheng Gu, Yanzheng Gu, Yanzheng Gu, Fengqing Fu, Fengqing Fu, Fengqing Fu, Yu Shen, Yu Shen, Yu Shen, Guangbo Zhang, Guangbo Zhang, Guangbo Zhang, Lanlan Feng, Xueguang Zhang, Xueguang Zhang, Xueguang Zhang, Youguo Chen, Fangrong Shen   +23 more
doaj   +1 more source

DIMEimmune: Robust estimation of infiltrating lymphocytes in CNS tumors from DNA methylation profiles

OncoImmunology, 2021
The interaction of CNS tumors with infiltrating lymphocytes plays an important role in their initiation and progression and might be related to therapeutic responses.
Sepehr Safaei, Malte Mohme, Judith Niesen, Ulrich Schüller, Michael Bockmayr   +4 more
doaj   +1 more source

Characterizing the immune microenvironment of malignant peripheral nerve sheath tumor by PD-L1 expression and presence of CD8+ tumor infiltrating lymphocytes. [PDF]

, 2016
BackgroundMalignant peripheral nerve sheath tumor (MPNST) is an aggressive sarcoma with few treatment options. Tumor immune state has not been characterized in MPNST, and is important in determining response to immune checkpoint blockade.
Bernthal, Nicholas, Chmielowski, Bartosz, Crompton, Joseph G, Dry, Sarah, Eilber, Fritz C, Federman, Noah, Jensen, Sarah, Li, Yunfeng, Nelson, Scott, Shurell, Elizabeth, Singh, Arun S, Tumeh, Paul   +11 more
core   +2 more sources

Characteristics of lymphocyte-infiltrating papillary thyroid cancer

Journal of Cancer Research and Practice, 2017
Background: The tumor-promoting or tumor-suppressing role of tumor-associated lymphocytes remains a subject of debate. We examined thyroid cancer data from The Cancer Genome Atlas in an attempt to define the relationship between lymphocyte infiltrates ...
Chi-Yu Kuo, Tsang-Pai Liu, Po-Sheng Yang, Shih-Ping Cheng   +3 more
doaj   +1 more source

Human plasmacytoid dendritic cells and cutaneous melanoma [PDF]

, 2020
The prognosis of metastatic melanoma (MM) patients has remained poor for a long time. However, the recent introduction of effective target therapies (BRAF and MEK inhibitors for BRAFV600-mutated MM) and immunotherapies (anti-CTLA-4 and anti-PD-1) has ...
Bugatti, Mattia, Consoli, Francesca, Monti, Matilde, Vermi, William, Vescovi, Raffaella   +4 more
core   +2 more sources

The prognostic significance of tumor-infiltrating lymphocytes assessment with hematoxylin and eosin sections in resected primary lung adenocarcinoma.

PLoS ONE, 2019
The prognostic significance of tumor-infiltrating lymphocytes has been determined in cancers of the lung, colon and breast, though there is no standardized method for using this prognostic indicator for lung cancer.
Ahrong Kim, So Jeong Lee, Jihyun Ahn, Won Young Park, Dong Hoon Shin, Chang Hun Lee, Hoon Kwon, Yeon Joo Jeong, Hyo Yeong Ahn, Hoseok I, Yeong Dae Kim, Jeong Su Cho   +11 more
doaj   +1 more source

Tumor-infiltrating B cells and T cells correlate with postoperative prognosis in triple-negative carcinoma of the breast

BMC Cancer, 2021
Background In this study, we investigated CD20+ TILs in triple-negative breast cancer (TNBC) and their relationship with T lymphocyte subsets (CD4+, CD8+, CD25+, and FOXP3+), including their combined prognostic value using an immunohistochemical staining
Hajime Kuroda, Tsengelmaa Jamiyan, Rin Yamaguchi, Akinari Kakumoto, Akihito Abe, Oi Harada, Atsuko Masunaga   +6 more
doaj   +1 more source

Regulation of CD4+NKG2D+ Th1 cells in patients with metastatic melanoma treated with sorafenib : role of IL-15Rα and NKG2D triggering [PDF]

, 2014
Beyond cancer-cell intrinsic factors, the immune status of the host has a prognostic impact on patients with cancer and influences the effects of conventional chemotherapies.
Auperin, Anne, Ayyoub, Maha, Caignard, Anne, Caillat-Zucman, Sophie, Chaba, Kariman, Chaput, Nathalie, Dessen, Philippe, Eggermont, Alexander, Flament, Caroline, Jacquelot, Nicolas, Jacques, Yannick, Mateus, Christine, Messaoudene, Meriem, Mortier, Erwan, Poirier-Colame, Vichnou, Porta, Camillo, Robert, Caroline, Romero, Ana I., Rusakiewicz, Sylvie, Valmor, Danila, Vielh, Philippe, Zitvogel, Laurence   +21 more
core   +2 more sources

Expression of TIM3/VISTA checkpoints and the CD68 macrophage-associated marker correlates with anti-PD1/PDL1 resistance: implications of immunogram heterogeneity. [PDF]

, 2020
Although immunotherapies have achieved remarkable salutary effects among subgroups of advanced cancers, most patients do not respond. We comprehensively evaluated biomarkers associated with the "cancer-immunity cycle" in the pan-cancer setting in order ...
Dressman, Devin, Eskander, Ramez, Glenn, Sean T, Goodman, Aaron, Ikeda, Sadakatsu, Kato, Shumei, Kumaki, Yuichi, Kurzrock, Razelle, Lee, Suzanna, Lenzo, Felicia L, Morrison, Carl, Nikanjam, Mina, Okamura, Ryosuke, Papanicolau-Sengos, Antonios   +13 more
core   +1 more source

Chemotherapy accelerates immune-senescence and functional impairments of Vδ2pos T cells in elderly patients affected by liver metastatic colorectal cancer. [PDF]

, 2019
Human (gamma delta) γδ T cells are unconventional innate-like lymphocytes displaying a broad array of anti-tumor activities with promising perspectives in cancer immunotherapy.
Bruni E, Cazzetta V, Cimino M, Dieli F, Donadon M, Leonardi G, Mavilio D., Mikulak J, Spata G, Torzilli G   +9 more
core   +1 more source