Results 11 to 20 of about 897,225 (318)

Lymphocytes in atherosclerosis [PDF]

Clinica Chimica Acta, 2012
It is well established that atherosclerosis is caused by an inflammatory process in the arterial intima. However, it is only in recent years that it has become clear that this inflammation is modulated by immune responses against plaque antigens. These antigens are primarily believed to be modified self-antigens such as oxidized LDL.
Wigren, Maria, Nilsson, Jan, Kolbus, Daniel   +2 more
openaire   +5 more sources

STIM1 at the plasma membrane as a new target in progressive chronic lymphocytic leukemia

Journal for ImmunoTherapy of Cancer, 2019
Background Dysregulation in calcium (Ca2+) signaling is a hallmark of chronic lymphocytic leukemia (CLL). While the role of the B cell receptor (BCR) Ca2+ pathway has been associated with disease progression, the importance of the newly described ...
Marjolaine Debant, Miguel Burgos, Patrice Hemon, Paul Buscaglia, Tinhinane Fali, Sarra Melayah, Nelig Le Goux, Christophe Vandier, Marie Potier-Cartereau, Jacques-Olivier Pers, Adrian Tempescul, Christian Berthou, Cristina Bagacean, Olivier Mignen, Yves Renaudineau   +14 more
doaj   +1 more source

Rheumatological features of Whipple disease

Scientific Reports, 2021
Whipple disease (WD) is a rare infectious systemic disease. Rheumatologists are at the frontline of WD diagnosis due to the early rheumatological manifestations. An early diagnosis is crucial, as usual anti-rheumatic drugs, especially TNF inhibitors, may
Alice Tison, Pauline Preuss, Clémentine Leleu, François Robin, Adrien Le Pluart, Justine Vix, Guillaume Le Mélédo, Philippe Goupille, Elisabeth Gervais, Grégoire Cormier, Jean-David Albert, Aleth Perdriger, Béatrice Bouvard, Jean-Marie Berthelot, Nathan Foulquier, Alain Saraux, the network of rheumatologists from the Grand Ouest “VICTOR HUGO”   +16 more
doaj   +1 more source

Pacific-Ciguatoxin-2 and Brevetoxin-1 Induce the Sensitization of Sensory Receptors Mediating Pain and Pruritus in Sensory Neurons

Marine Drugs, 2021
Ciguatera fish poisoning (CFP) and neurotoxic shellfish poisoning syndromes are induced by the consumption of seafood contaminated by ciguatoxins and brevetoxins.
Ophélie Pierre, Maxime Fouchard, Nelig Le Goux, Paul Buscaglia, Raphaël Leschiera, Richard J. Lewis, Olivier Mignen, Joachim W. Fluhr, Laurent Misery, Raphaële Le Garrec   +9 more
doaj   +1 more source

Lymphocytic gastritis [PDF]

Polish Journal of Pathology, 2019
Organic basis of gastrointestinal symptoms is in the scope of many specialists. In this article lymphocytic gastritis, relatively newly described and not widely-known entity is presented. The lesion is characterized by presence of numerous mature lymphocytes in the surface and foveolar epithelium, as well as lymphocytic infiltration of the lamina ...
Michał Puderecki, Lech Wronecki, Katarzyna Cięszczyk, Justyna Szumiło   +3 more
openaire   +4 more sources

Simulated patient and role play methodologies for communication skills and empathy training of undergraduate medical students

BMC Medical Education, 2020
Background Verbal and non-verbal communication, as well as empathy are central to patient-doctor interactions and have been associated with patients’ satisfaction. Non-verbal communication tends to override verbal messages.
Cristina Bagacean, Ianis Cousin, Anne-Helene Ubertini, Mohamed El Yacoubi El Idrissi, Anne Bordron, Lolita Mercadie, Leonor Canales Garcia, Jean-Christophe Ianotto, Philine De Vries, Christian Berthou   +9 more
doaj   +1 more source

Combining cytogenetic and epigenetic approaches in chronic lymphocytic leukemia improves prognosis prediction for patients with isolated 13q deletion

Clinical Epigenetics, 2017
Background Both defective DNA methylation and active DNA demethylation processes are emerging as important risk factors in chronic lymphocytic leukemia (CLL).
Cristina Bagacean, Christelle Le Dantec, Christian Berthou, Adrian Tempescul, Hussam Saad, Anne Bordron, Mihnea Zdrenghea, Victor Cristea, Nathalie Douet-Guilbert, Yves Renaudineau   +9 more
doaj   +1 more source

Patterns of Peripheral Blood B-Cell Subtypes Are Associated With Treatment Response in Patients Treated With Immune Checkpoint Inhibitors: A Prospective Longitudinal Pan-Cancer Study

Frontiers in Immunology, 2022
BackgroundImmune checkpoint inhibitors (ICIs) have revolutionized systemic anti-tumor treatments across different types of cancer. Nevertheless, predictive biomarkers regarding treatment response are not routinely established yet.
Dominik A. Barth, Stefanie Stanzer, Jasmin A. Spiegelberg, Thomas Bauernhofer, Gudrun Absenger, Joanna Szkandera, Armin Gerger, Maria A. Smolle, Georg C. Hutterer, Sascha A. Ahyai, Tobias Madl, Tobias Madl, Florian Posch, Jakob M. Riedl, Christiane Klec, Philipp J. Jost, Julia Kargl, Julia Kargl, Martin H. Stradner, Martin Pichler, Martin Pichler   +20 more
doaj   +1 more source

Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs

Cell Reports, 2021
Summary: B lymphocytes are exquisitely sensitive to fluctuations in nutrient signaling by the Rag GTPases, and 15% of follicular lymphomas (FLs) harbor activating mutations in RRAGC. Hence, a potential therapeutic approach against malignant B cells is to
Ana Ortega-Molina, Cristina Lebrero-Fernández, Alba Sanz, Nerea Deleyto-Seldas, Ana Belén Plata-Gómez, Camino Menéndez, Osvaldo Graña-Castro, Eduardo Caleiras, Alejo Efeyan   +8 more
doaj   +1 more source

Elevations in Liver Transaminases in COVID-19: (How) Are They Related?

Frontiers in Medicine, 2021
Liver involvement in COVID-19 is not yet well-understood, but elevations in liver transaminases have been described to occur in 14–53% of the cases and are more frequently seen in severe disease.
Henrique Pott-Junior, Natália Queiroz Prado Bittencourt, Silvana F. G. Chacha, Rafael Luís Luporini, Rafael Luís Luporini, Marcia Regina Cominetti, Fernanda de Freitas Anibal, Fernanda de Freitas Anibal   +7 more
doaj   +1 more source