Results 231 to 240 of about 927,466 (317)

A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy‐Induced Cardiotoxicity

Advanced Science, EarlyView.
In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Jimeen Yoo, Gayatri Mainkar, Matteo Ghiringhelli, Bernardo Gindri Dos Santos, Magdalena M. Żak, Keerat Kaur, Ann Anu Kurian, Matthew Adjmi, Segev Sharon, Eftychia Markopoulou, Lucia Žigová, Daniela Hirsch, Sydney Pessin, Rachel Hanan, Juan Luis Escano Abreu, Niki Brisnovali, Nicole Dubois, Leigh Goedeke, Mengcheng Shen, Lior Zangi   +19 more
wiley   +1 more source

Warthin's Tumor Involved by Monoclonal B-Cell Lymphocytosis: A Case Report. [PDF]

Cureus
Kindy A, Wang Z, Gautam R, Bennett R, Wang Z.   +4 more
europepmc   +1 more source

An activation antigen on a subpopulation of B lymphocytes identified by the monoclonal antibody CMRF-17.

, 1989
S. F. Peach, S.E. Davidson, Judith L. McKenzie, J C Nimmo, Derek N.J. Hart   +4 more
openalex   +1 more source

Diagnostic value of neutrophil/lymphocyte ratio, platelet/lymphocyte ratio and systemic immune-inflammation index for predicting the severity of acute pancreatitis [PDF]

Amir Mohammad Salehi, Ramin Rezaei, Atefeh Sadeghi, Erfan Ayubi, Maryam Hasanzarrini, Ahmad Rezaee Azandaryani, Mehta Razzaghi   +6 more
openalex   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, EarlyView.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

Repeated administration of cannabidiol decreases splenic lymphocyte subset numbers in rats. [PDF]

Int J Immunopathol Pharmacol
Turkki TH, Jankowski MM, Glac W, Badtke P, Saito VM, Swiergiel AH, Ignatowska-Jankowska BM.   +6 more
europepmc   +1 more source

Effect of nickel chloride on mouse T-lymphocyte subsets.

, 1998
LI Da-ming, Choon Nam Ong, Victor Ng, Charles Y. Tan   +3 more
openalex   +1 more source

Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing, Xiaolan Li, Xiang He, Junyi Wang, Yi Yang, Manling Jiang, Bingbing Yan, Lei Zhang, Anying Xiong, Qin Ran, Guoping Li   +10 more
wiley   +1 more source

Correlation Between CD38⁺ Cell Levels and Pulmonary Tuberculosis Complicated with Diabetes Mellitus: A Retrospective Analysis Based on Lymphocyte Subsets and Clinical Features. [PDF]

Diabetes Metab Syndr Obes
Wang Y, Mao W, Xu L, Xu W.
europepmc   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source