Results 241 to 250 of about 1,286,040 (313)

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Exercise-mobilized lymphocytes enhance antibody-based immunotherapy in multiple myeloma through CD16⁺ NK cell-mediated cytotoxicity. [PDF]

J Transl Med
Chou L, Valenzuela AM, McDougal LM, Baker FL, Katsanis E, Simpson RJ.   +5 more
europepmc   +1 more source

Multi‐Organelle Stress‐Induced Paraptosis by a ROS‐Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu, Haozhe Ren, Hua Li, Jinghan Zhao, Miaomiao Cao, Tian Tang, Youbei Qiao, Liting Chen, Tiehong Yang, Hong Wu   +9 more
wiley   +1 more source

On the mechanism of action of the cytostatic drug anguidine and of the immunosuppressive agent ovalicin, two sesquiterpenes from fungi [PDF]

, 1978
Hartmann, G. R., Richter, H., Weiner, E. M., Zimmermann, Wolfgang   +3 more
core  

Childhood adversity and increased cytokine release from peripheral mononuclear cells of CHD patients - a pilot study. [PDF]

BMC Cardiovasc Disord
Wiche H, Anhuef O, Martinache S, Simon JJ, Frey N, Backs J, Friederich HC, Schultz JH, Bruns B.   +8 more
europepmc   +1 more source

Prostaglandin E₂ induces dendritic cell dysfunction in skin involvement of breast cancer. [PDF]

Cell Death Dis
Wang J, Zhong X, Liu X, Qian Z, Zhu J, Lin H, Zhang J, Zhang W, Du S, Yang L, Nie M.   +10 more
europepmc   +1 more source

Immune-inflammatory mediators of frailty and long COVID in older adults: a prospective cohort study. [PDF]

BMC Geriatr
He S, Liu Y, Li Y, Ji L, Liu Y, Yan J, Zhang Z, Sun H, Gao M, Wu S.   +9 more
europepmc   +1 more source