Results 231 to 240 of about 1,286,040 (313)

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source

Specific Deficiency of Naïve CD4+ T Lymphocytes Characterizes Heart Failure and Heightens Mortality Risk in the HRS. [PDF]

J Am Heart Assoc
Zidar DA, Freeman ML, Wilson BM, Al-Kindi S, Chung MK, Gunzler DD, Parikh SA, Sharma AA, Shive CL, Jain M, Skarbinski J, Tang WHW, Dalton JE, Anthony DD, Chan TA, Thyagarajan B.   +15 more
europepmc   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Enterotoxigenic <i>Escherichia coli</i>-induced intestinal epithelial necroptosis drives lamina propria immune cell pyroptosis and mucosal injury in piglets. [PDF]

Front Immunol
Wu X, Liu Y, Wu S, Wei H, Peng J.
europepmc   +1 more source

Decoding the Cardiac Immune Microenvironment and Fibroblast Crosstalk in Radiotherapy Combined with Immunotherapy‐Induced Cardiac Fibrosis Based on Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo, Ying Yu, Zhimin Zeng, Yanxin Chen, Yali Yi, Zhiqin Lu, Fujuan Zeng, Peng Xu, Daya Luo, Leifeng Chen, Anwen Liu   +10 more
wiley   +1 more source

Hypoxemia-induced TIGIT expression in obstructive sleep apnea is reversible with continuous positive airway pressure. [PDF]

Front Immunol
Pérez-Moreno P, Díaz-García E, López-Fernández C, García-Sánchez A, Mañas E, Pozuelo-Sánchez L, Torres-Vargas M, Martínez-Cerón E, Casitas R, Galera R, Fernández Velasco M, Del Peso L, García-Río F, Cubillos-Zapata C.   +13 more
europepmc   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

A high density of T-cell lymphocytes and Tregs subset correlate to a worse survival in major salivary gland carcinomas. [PDF]

Sci Rep
Anconelli D, Vasuri F, Novelli L, Saragoni L, Messerini L, Saieva C, Cantone E, Muscatello L, Bartoletti G, Niccolai E, Amedei A, Franchi A, Ambrosio MR.   +12 more
europepmc   +1 more source

DADA Enhances CD8+ T Cell Stemness to Improve Anti‐Tumor Immunity and Immunotherapy Efficacy

Advanced Science, EarlyView.
Diisopropylamine dichloroacetate (DADA) enhances CD8+ T cell stemness by improving OXPHOS and mitochondrial fitness in a PDK1‐depenpendent manner. This metabolic shift strengthens CD8+ T cell anti‐tumor immunity, improves responses to PD‐1 blockade, and endows CAR‐T cells with prolonged persistence and resistance to terminal exhaustion, highlighting a ...
Mingyue Bi, Fei Li, Heng Jiang, Lingling Gu, Mengjie Sun, Kunyu Lu, Pianpian Liu, Ruyue Xie, Wenqiang Ma, Meijuan Zheng, Xianwei Wang, Xuefu Wang, Jingjing Cong   +12 more
wiley   +1 more source

Systematic Evaluation of Physicochemical Properties of PEGylated Gold Nanorods Reveals Cell-Specific Uptake Determinants in Human Immune Cell Subsets. [PDF]

Small Sci
Roy Chaudhuri T, Giesler H, Kovacevic Sarmiento M, Lamers K, Hechler M, Erkelenz M, Haferkamp M, Schirrmann R, Nachev M, Bosnjakovic R, Sures B, Schlücker S, Brandau S.   +12 more
europepmc   +1 more source