Results 61 to 70 of about 693,895 (386)

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Oral manifestations leading to the diagnosis of acute lymphoblastic leukemia in a young girl

Journal of Indian Society of Pedodontics and Preventive Dentistry, 2012
Background: oral complications may be leukemia′s first presentation. Aim: to present a case of a young girl with a swelling on the face that led to the diagnosis of acute lymphoblastic leukemia is reported. Results: a 10-year old anemic girl was referred
B A Silva, CRB Siqueira, PHS Castro, S S Araújo, LER Volpato   +4 more
doaj   +1 more source

Transplantation of embryonic spleen tissue reveals a role for adult non-lymphoid cells in initiating lymphoid tissue organization [PDF]

, 2009
In this report we describe a transplantation system where embryonic spleens are grafted into adult hosts. This model can be used to analyze the cellular and molecular requirements for the development and organization of splenic microenvironments.Whole ...
Aloisi, Bajenoff, Bekiaris, Bekiaris, Brendolan, Chen, Cupedo, Cupedo, Cupedo, Drayton, Eberl, Fan, Fu, Fu, Futterer, Honda, Kim, Kim, Kim, Kim, Kim, Kratz, Link, Luther, Luther, Luther, Mackay, Mebius, Meier, Ngo, Ngo, Nolte, Rennert, Rossi, Scandella, Sun, Togni, Veiga-Fernandes, Vondenhoff, Wang, White, Withers, Yokota, Yoshida   +43 more
core   +2 more sources

Lymphoid Reconstruction and Vaccines

Biology of Blood and Marrow Transplantation, 2007
Allogeneic HSCT is the most reliable, robust, and effective cell-based biotherapy currently available to pediatric and adult patients with hematologic malignancies. The central role of donor-derived lymphocytes in mediating an effective antitumor effect, preventing and controlling opportunistic infections, and causing GVHD is well documented in animal ...
Hermann Einsele, Ronald E. Gress, Laurence J.N. Cooper, Krishna V. Komanduri   +3 more
openaire   +3 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

A Rare Case of Primary Vulvar Diffuse Large B‐Cell Lymphoma: A Case Report

Clinical Case Reports
Primary vulvar diffuse large B‐cell lymphoma is a diagnostically challenging malignant tumor due to its low incidence and diverse clinical presentations. It has a good prognosis and is usually radio‐chemotherapy‐responsive.
M. Singh, S. Ngakhusi, A. Shrestha, P. Subedi, K. Khadka, H. P. Dhakal   +5 more
doaj   +1 more source

Tertiary lymphoid organs in central nervous system autoimmunity [PDF]

, 2016
Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation in the central nervous system (CNS), which results in permanent neuronal damage and substantial disability in patients.
Mitsdoerffer, M., Peters, A.
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source