Results 1 to 10 of about 42,543 (244)

Acetylshikonin suppressed growth of colorectal tumour tissue and cells by inhibiting the intracellular kinase, T-lymphokine-activated killer cell-originated protein kinase. [PDF]

Br J Pharmacol, 2020
Overexpression or aberrant activation of the T‐lymphokine‐activated killer cell‐originated protein kinase (TOPK) promotes gene expression and growth of solid tumours, implying that TOPK would be a rational target in developing novel anticancer drugs ...
Zhao R, Choi BY, Wei L, Fredimoses M, Yin F, Fu X, Chen H, Liu K, Kundu JK, Dong Z, Lee MH.   +10 more
europepmc   +4 more sources

3-Deoxysappanchalcone Inhibits Skin Cancer Proliferation by Regulating T-Lymphokine-Activated Killer Cell-Originated Protein Kinase in vitro and in vivo [PDF]

Frontiers in Cell and Developmental Biology, 2021
BackgroundSkin cancer is one of the most commonly diagnosed cancers worldwide. The 5-year survival rate of the most aggressive late-stage skin cancer ranges between 20 and 30%. Thus, the discovery and investigation of novel target therapeutic agents that
Xiaorong Fu, Xiaorong Fu, Ran Zhao, Ran Zhao, Goo Yoon, Jung-Hyun Shim, Jung-Hyun Shim, Bu Young Choi, Fanxiang Yin, Fanxiang Yin, Fanxiang Yin, Beibei Xu, Beibei Xu, Kyle Vaughn Laster, Kangdong Liu, Kangdong Liu, Zigang Dong, Zigang Dong, Mee-Hyun Lee, Mee-Hyun Lee, Mee-Hyun Lee   +20 more
doaj   +2 more sources

Lymphokine-activated killer cell transplantation after anti-cancer treatment in two aged cats [PDF]

Open Veterinary Journal, 2019
Immunotherapy improves both survival and remission rates after cancer surgery in humans, but its veterinary use has been limited. We determined the safety and feasibility of lymphokine-activated killer (LAK) cell transplantation in two aged cats that had
Noritaka Maeta, Katsutoshi Tamura, Hiroshi Takemitsu, Masahiro Miyabe   +3 more
doaj   +2 more sources

Phosphorylation of IκBα at serine 32 by T-lymphokine-activated killer cell-originated protein kinase is essential for chemoresistance against doxorubicin in cervical cancer cells. [PDF]

J Biol Chem, 2013
Background: The regulatory mechanism of TOPK underlying cancer cell survival remains unknown. Results: TOPK directly interacts with and phosphorylates IκBα at Ser-32.
Park JH, Yoon DS, Choi HJ, Hahm DH, Oh SM.   +4 more
europepmc   +2 more sources

Effects of transforming growth factor-beta on human lymphokine-activated killer cell precursors. Autocrine inhibition of cellular proliferation and differentiation to immune killer cells. [PDF]

Journal of Immunology, 1988
With subpopulations of human lymphoid cells that were enriched for lymphokine-activated killer (LAK) cell precursors, studies were performed to examine the effects of transforming growth factor-beta (TGF-beta) on their IL-2-dependent growth and ...
A Kasid, Gillian I. Bell, E P Director
openalex   +2 more sources

Recent advances in adoptive cell therapy for cancer immunotherapy [PDF]

Frontiers in Immunology
Adoptive cell therapy (ACT), a key direction in tumor immunotherapy, has achieved remarkable progress in recent years. This paper systematically reviews the current status and future trends of ACT, covering lymphokine-activated killer cells (LAK), tumor ...
Jiameng Qian, Jiameng Qian, Yuhua Liu, Yuhua Liu   +3 more
doaj   +2 more sources

Lymphokine-activated killer cell susceptibility and adhesion molecule expression of multidrug resistant breast carcinoma [PDF]

Cancer Cell International, 2006
Reports showing susceptibility of multidrug resistant (MDR) cancer cells to immune effectors, together with P-glycoprotein (P-gp) expression in immune effector subsets, including immature natural killer (NK) cells, and some activated T cells, suggest P ...
Kerr Pauline E, Savas Burhan, Pross Hugh F   +2 more
doaj   +2 more sources

Characterization of Transendothelial Migratory Lymphokine‐activated Killer Cells [PDF]

Japanese Journal of Cancer Research, 1996
We examined the killing activity of transmigrated lymphokine‐activated killer (LAK) cells and their surface molecules associated with both transendothelial migration and cytotoxicity, using human umbilical vein‐derived endothelial cell (HUVEC) monolayers on fibronectin with gelatin separating the upper chamber from the lower chamber.
Koji Nakano, Masao Eura, Kazuaki Chikamatsu, Keisuke Masuyama, Takeru Ishikawa   +4 more
openalex   +4 more sources

A Tumor Cell-Selective Inhibitor of Mitogen-Activated Protein Kinase Phosphatases Sensitizes Breast Cancer Cells to Lymphokine-Activated Killer Cell Activity. [PDF]

J Pharmacol Exp Ther, 2017
Kaltenmeier CT, Vollmer LL, Vernetti LA, Caprio L, Davis K, Korotchenko VN, Day BW, Tsang M, Hulkower KI, Lotze MT, Vogt A.   +10 more
europepmc   +2 more sources

CAR T cell therapy for central nervous system solid tumors: current progress and future directions [PDF]

Frontiers in Immunology
Central nervous system (CNS) tumors are the second most common type of cancer in children and remain the leading cause of mortality in pediatric oncology.
Yaroslav Kaminskiy, Vitaly Degtyarev, Alexey Stepanov, Michael Maschan   +3 more
doaj   +2 more sources