Aim. To evaluate the antitumor efficacy of our developed drug based on cytotoxic T lymphocytes genetically modified with a chimeric antigen receptor (CAR) specific to the CA125 antigen in relation to both CA125-positive and CA125negative cell cultures ...
T. M. Kulinich+7 more
doaj +1 more source
Natural cytotoxicity impairment in familial haemophagocytic lymphohistiocytosis. [PDF]
Ten children with the characteristic clinical and haematological features of haemophagocytic lymphohistiocytosis are reported. Four patients treated with a combination of drugs comprising etoposide, methotrexate, and steroids were in complete remission ...
Aricò M+6 more
core
Expression of Interleukin-1 and Interleukin-1 Receptors Type 1 and Type 2 in Hodgkin Lymphoma
Signaling through the IL-1-receptor type 1 (IL-1R1), IL-1 is required for initiation and maintenance of diverse activities of the immune system. A second receptor, IL-1R2, blocks IL-1 signal transduction. We studied expression of IL-1beta, IL-1R1, and IL-
Berdel, W.E. (Wolfgang)+3 more
core +1 more source
Heterogeneity of lymphokine-activated killer cells induced by IL-2. Separate lymphoid subpopulations lyse tumor, allogeneic blasts, and modified syngeneic blasts. [PDF]
Alan Kawarai Lefor+2 more
openalex +1 more source
Flowcytometry – A rapid tool to correlate functional activities of human peripheral blood lymphocytes with their corresponding phenotypes after in vitro stimulation [PDF]
Background: While dealing with mixed in vitro lymphocyte cultures one is faced with the problem of relative contributions of different populations to the activity being studied.
Narayanan, P R, Nirmala, R
core
Induction of lymphokine-activated killer-like cells by cancer chemotherapy. [PDF]
Tatsuo Kiyohara+5 more
openalex +1 more source
Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C. [PDF]
NKB1 is one member of a growing family of killer cell inhibitory receptors (KIR). It is expressed on natural killer (NK) cells and T cells, and has been shown to inhibit cytolytic functions of these cells upon interacting with its ligand, HLA-B (Bw4). We
Fry, AM, Lanier, LL, Weiss, A
core +1 more source
Identification and characterization of a cell-surface molecule that is selectively induced on rat lymphokine-activated killer cells. [PDF]
John B. Imboden+4 more
openalex +1 more source
Inhibition of lymphokine-activated killer cell-mediated cytotoxicity by phorbol ester. [PDF]
Takashi Nishimura+2 more
openalex +1 more source
Lymphocytes expressing type 3 complement receptors proliferate in response to interleukin 2 and are the precursors of lymphokine-activated killer cells. [PDF]
J. Dixon Gray, David A. Horwitz
openalex +1 more source