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Nano-Bacillus Calmette-Guérin immunotherapies for improved bladder cancer treatment. [PDF]
J Zhejiang Univ Sci BZeng S, Xing S, Zhang Y, Wang H, Liu Q.
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Lymphokine activated killer cells
Blut, 1989Various subpopulations of human leukocytes may be induced by lymphokines to exert cytotoxic activity. In man major histocompatibility complex non-restricted tumor cell lysis by interleukin-2 (IL-2) induced peripheral blood lymphocytes is attributed mainly to natural killer cells.
Wolfgang Oster +3 more
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Heterogeneity of the lymphokine-activated killer cell phenotype
Cellular Immunology, 1991Lymphokine-activated killer cells (LAK) are functionally defined by their ability to mediate the MHC-unrestricted lysis of a range of tumor targets, while sparing normal cells. They can also lyse TNP-modified normal syngeneic lymphoblasts. We show here that lysis of TNP-modified targets is mediated by CD8+ LAK in a self-MHC-restricted manner, whereas ...
Brian S. Chadwick, Richard G. Miller
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Effect of ouabain on lymphokine-activated killer cells
International Journal of Immunopharmacology, 1994A large amount of evidence points towards the potential role of lymphokine activated killer (LAK) cells as tools in the treatment of chronically stressed conditions, such as cancer. The modulation of this activity by biologically active endogenous compounds of the HPA (hypothalamic-pituitary-adrenal) axis, however, is not completely understood. Ouabain,
I.F. Mediano +5 more
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Cellular Immunology, 1989
The coculture of rat bone marrow cells with recombinant interleukin-2 induced the generation of cells mediating natural killer (NK) activity and subsequent lymphokine-activated killer (LAK) activity depending upon the dose of IL-2 and time of culture. NK activity was detected as early as 4 to 5 days after the addition of IL-2 and could be evoked with ...
John C. Hiserodt +4 more
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The coculture of rat bone marrow cells with recombinant interleukin-2 induced the generation of cells mediating natural killer (NK) activity and subsequent lymphokine-activated killer (LAK) activity depending upon the dose of IL-2 and time of culture. NK activity was detected as early as 4 to 5 days after the addition of IL-2 and could be evoked with ...
John C. Hiserodt +4 more
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Modulation of natural killer and lymphokine-activated killer cell cytotoxicity by lactoferrin [PDF]
Journal of Leukocyte Biology, 1992 Abstract Natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxic functions can be strongly augmented by the iron-carrier protein lactoferrin (LF). LF significantly enhances NK and LAK activities when added at the beginning of NK or LAK cytotoxicity assays.
Hungyi Shau +2 more
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Lymphokine-Activated Killer Cell Activity in Lung Cancer
Chest, 1991This study evaluates local pulmonary immune effector cell lytic activity. Purified lymphocyte populations were isolated from BALF obtained from 18 patients with bronchogenic carcinoma, six patients with lung disorders other than cancer, and ten normal control volunteers matched for age and smoking history. These cells were evaluated for NK and LAK cell
Akira Funahashi, Ann V. Lefever
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Apheresis techniques in lymphokine‐activated killer cell production
Journal of Clinical Apheresis, 1988AbstractAdoptive transfer of autologous lymphokine‐activated killer cells (LAK) in conjunction with recombinant interleu‐kin‐2 (rIL‐2) has been reported to produce significant regression in metastatic disease in patients with advanced cancer. In an effort to confirm the results reported by the Surgery Branch of the National Cancer Institute, the same ...
Irena Sniecinski +3 more
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Lysis of endothelial cells by autologous lymphokine-activated killer cells
Cancer Immunology Immunotherapy, 1994The mechanisms of lysis of endothelial cells derived from human umbilical vein (HUVEC) by autologous lymphokine-activated killer (LAK) cells, generated from cord blood lymphocytes of the same donor, were investigated. Freshly isolated HUVEC as well as HUVEC cultured for several passages were efficiently lysed by autologous LAK cells, and their ...
Yoichi Shibata +8 more
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Lymphokine-Activated Killer Cells: Biology and Relevance to Disease [PDF]
Cancer Investigation, 1993 (1993). Lymphokine-Activated Killer Cells: Biology and Relevance to Disease. Cancer Investigation: Vol. 11, No. 4, pp. 420-439.
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