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Immunotherapy of cancer with lymphokines and lymphokine‐activated killer cells
Seminars in Surgical Oncology, 1991AbstractOur expanding knowledge of the immune system has provided a basis of rationality for immunotherapy. Some non‐specific immunotherapy has achieved the status of standard treatment: interferon in hairy cell leukemia and chronic myelogenous leukemia, BCG in bladder cancer, and levamisole in colon cancer adjuvant therapy.
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Cellular Immunology, 1986
Pretreatment of mice with rabbit anti-asialo GM1 removes both natural killer (NK) effector cells and NK cells responsive to interleukin 2 (IL-2). Spleen cells from these mice do possess normal lymphokine-activated killer (LAK) activity. Young mice (less than 3 weeks of age) do not have NK activity and do not possess IL-2-inducible NK effector cells ...
Mark D. Smith +2 more
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Pretreatment of mice with rabbit anti-asialo GM1 removes both natural killer (NK) effector cells and NK cells responsive to interleukin 2 (IL-2). Spleen cells from these mice do possess normal lymphokine-activated killer (LAK) activity. Young mice (less than 3 weeks of age) do not have NK activity and do not possess IL-2-inducible NK effector cells ...
Mark D. Smith +2 more
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Transfusion, 1993
The use of lymphokine‐activated killer (LAK) cell therapy in delayed treatment requires the use of cryopreserved effector cells. The purpose of this study was to determine the optimal cryopreservation protocol for the maintenance of cytotoxic activity in mononuclear cells (MNCs). MNCs were cryopreserved with dimethyl sulfoxide or 1,2‐propanediol before
Fèlix Rueda +7 more
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The use of lymphokine‐activated killer (LAK) cell therapy in delayed treatment requires the use of cryopreserved effector cells. The purpose of this study was to determine the optimal cryopreservation protocol for the maintenance of cytotoxic activity in mononuclear cells (MNCs). MNCs were cryopreserved with dimethyl sulfoxide or 1,2‐propanediol before
Fèlix Rueda +7 more
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Lymphokine activated killer cells in murine coxsackievirus B3 myocarditis
Basic Research in Cardiology, 1997The purpose of the present study was to determine whether lymphokine activated killer (LAK) cells were involved in the development of coxsackievirus B3 (CB3) myocarditis in both the acute viremic (Experiment I) and the subacute aviremic (Experiment II) stages.
Masahiko Kurokawa +3 more
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The Contribution of Natural Killer and T-Cells to the Lymphokine-Activated Killer Cell Phenomenon
2018In vitro culture of lymphocytes in interleukin-2 (IL-2) results in the generation of cytotoxic cells that lyse a broad spectrum of solid tumors, as well as hematopoietic cell tumors, without deliberate immunization. Peripheral blood is the source for lymphocytes used in human Lymphokine-activated killer (LAK) immunotherapy. The predominant effectors of
Joseph H. Phillips +4 more
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Natural killer cell and lymphokine-activated killer cell activity against melanocytes in vitiligo
Journal of the American Academy of Dermatology, 1995Vitiligo is a common disease of unknown cause. Previous studies have shown abnormalities in natural killer (NK) cell cytotoxicity in patients when NK-sensitive erythroleukemic cell lines were used as target cells.The purpose of this study was to use melanocytes directly as target cells to determine NK and lymphokine-activated killer (LAK) cell ...
Hoang N Pham +4 more
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Interleukin-2 and lymphokine activated killer cells
Transfusion Science, 1991Interleukin-2 (IL-2) is a cytokine derived pendently to IL-2, but with more than from T-helper lymphocytes. Originally lOO-fold lower afflnity (I& = 10V9 M). known as T-cell growth factor it was Nevertheless, binding leads to internalidiscovered in the supernatants of PHAzation and activation.
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Lymphokine-activated killer cell activity
Immunology Today, 1988Peter E. Lipsky, Dwain L Thiele
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Cellular Immunology, 1985
Precursors and effectors of murine lymphokine-activated killer cells, natural killer cells, and cytotoxic T lymphocytes are compared. Natural killer cells are resistant to gamma-irradiation (1000 R) whereas precursors of lymphokine-activated killer cells and cytotoxic T lymphocytes are sensitive.
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Precursors and effectors of murine lymphokine-activated killer cells, natural killer cells, and cytotoxic T lymphocytes are compared. Natural killer cells are resistant to gamma-irradiation (1000 R) whereas precursors of lymphokine-activated killer cells and cytotoxic T lymphocytes are sensitive.
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Heterogeneity of Lymphokine-Activated Killer Cell Precursors1 [PDF]
, 2015 Alexander C. Barron +2 more
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