Results 21 to 30 of about 16,485 (256)

Effector Functions of Natural Killer Cell Subsets in the Control of Hematological Malignancies. [PDF]

, 2015
Treatment of hematological malignant disorders has been improved over the last years, but high relapse rate mainly attributable to the presence of minimal residual disease still persists.
Biassoni, Biron, Björklund, Brodin, Bryceson, Burns, Campbell, Cooley, Cooper, Cooper, Curti, Davies, Di Santo, Di Santo, Farag, Fehniger, Fogler, Foley, Freud, Gasser, Gilfillan, Grimm, Guethlein, Herberman, Huntington, Joncker, Kiessling, Killig, King, Kröger, Lajoie, Lanier, Leong, Ljunggren, Lowe, Lundqvist, Mancusi, McQueen, Miller, Moretta, Moretta, Moretta, Nguyen, Oevermann, Ouyang, Perussia, Phillips, Romagnani, Romee, Rosenberg, Rosenberg, Rosenberg, Ruggeri, Santoni, Stabile, Stabile, Stern, Stringaris, Thielens, Torelli, Trinchieri, Trinchieri, Vago, Valés-Gómez, Venstrom, Vivier, Whitelaw, Zorn   +67 more
core   +1 more source

Immunoregulation of natural and lymphokine-activated killer cells by selenium [PDF]

Immunopharmacology, 1990
The effect of selenium (Se) on natural killer (NK) and lymphokine-activated killer (LAK) cell activities and proliferative responses of human lymphocytes was studied in vitro. Direct addition of Se at 1.0 microgram/ml final concentration to the mixture of target and effector cells during a 4 h cytotoxicity assay significantly suppressed the NK activity
Nair, Madhavan P. N., Schwartz, Stanley A.   +1 more
openaire   +4 more sources

A combination of soluble helper factors bypasses the requirement for stimulator cells and induces nonspecific cytotoxic T cell responses [PDF]

, 1985
The specificity of cytotoxic T lymphocyte (CTL) responses generated in the presence of lymphokines was studied. Thymic responder cells were activated in the presence of stimulator cells that differed in their metabolic activity.
Dröge, W., Falk, Werner, Männel, D. N.
core   +1 more source

Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins [PDF]

, 1993
The human serine proteases granzymes A and B are expressed in cytotoplasmic granules of activated cytotoxic T lymphocytes and natural killer cells. Recombinant granzyme A and granzyme B proteins were produced in bacteria, purified and then used to raise ...
Borst, Jannie, Brakenhoff, Just P.J., Hack, C. Erik, Kamp, Angela M., Kummer, J. Alain, Radosevic, K., Radosevic, Katarina, van Katwijk, Marcel, van Leeuwen, Anne Marie, Verweij, Cornelis L.   +9 more
core   +11 more sources

Mechanism of pentoxifylline mediated down-regulation of killer lineage cell functions

Mediators of Inflammation, 1993
The authors reported recently that endotoxaemia mediated elevated levels of tumour necrosis factor (TNF-α) and interleukin-1α (IL-1α) were involved in the pathophysiology of acute heat stroke patients. Pentoxifylline (PTX) is known to modulate neutrophil
R. S. Parhar, P. Ernst, K. Sheth, M. Einspenner, S. Al-Sedairy   +4 more
doaj   +1 more source

CD8⁺, HLA-unrestricted, cytotoxic T-lymphocyte line against malignant melanoma

Journal of Translational Medicine, 2005
A CD8+ cytotoxic T lymphocyte (CTL) line was derived from the peripheral blood mononuclear cells of a patient with primary melanoma. The CD8+ CTL line specifically lysed the autologous primary melanoma cells and not the natural killer cell-sensitive K562
Guerry DuPont, Caputo Laura, Somasundaram Rajasekharan, Herlyn Dorothee   +3 more
doaj   +1 more source

The potential of cannabinoids in the treatment of lung cancer

Journal of Education, Health and Sport, 2022
Introduction: Lung cancer is the number-one cause of death due to neoplasms worldwide. The 5-year overall survival rate is only 22%. In advanced stages, the therapeutic options are limited to chemotherapy, radiotherapy, molecularly targeted therapy and ...
Małgorzata Drozd, Paweł Marzęda, Jakub Czarnota, Michał Dobrzyński, Tomasz Skubel, Iga Dudek, Natalia Rybak   +6 more
doaj   +1 more source

Natural killer and lymphokine activated killer cell functions in Hodgkin's disease [PDF]

British Journal of Cancer, 1990
We report the natural killer (NK) and lymphokine activated killer (LAK) cell activities in peripheral blood lymphocytes (PBL) from untreated patients with Hodgkin's disease (HD) and from healthy donors. The frequency of LAK cell precursors was also studied using limiting dilution analysis (LDA).
Suresh H. Advani, Gangal Sg, R. J. Tatake, N. Rajaram   +3 more
openaire   +3 more sources

A Review of Immunotherapeutic Strategies in Canine Malignant Melanoma

Veterinary Sciences, 2019
In dogs, melanomas are relatively common tumors and the most common form of oral malignancy. Biological behavior is highly variable, usually aggressive, and frequently metastatic, with reported survival times of three months for oral or mucosal melanomas
Ramón M. Almela, Agustina Ansón
doaj   +1 more source

Canine melanoma: A review of diagnostics and comparative mechanisms of disease and immunotolerance in the era of the immunotherapies

Frontiers in Veterinary Science, 2023
Melanomas in humans and dogs are highly malignant and resistant to therapy. Since the first development of immunotherapies, interest in how the immune system interacts within the tumor microenvironment and plays a role in tumor development, progression ...
Valentina B. Stevenson, Shawna Klahn, Shawna Klahn, Tanya LeRoith, William R. Huckle   +4 more
doaj   +1 more source