Results 21 to 30 of about 42,543 (244)

Lymphokine-activated killer cell phenomenon. Lysis of natural killer- resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes

Journal of Experimental Medicine, 1982
Activation in lectin-free interleukin 2 (IL-2) containing supernatants of peripheral blood mononuclear leukocytes (PBL) from cancer patients or normal individuals resulted in expression of cytotoxicity toward 20 of 21 natural killer (NK)-resistant fresh ...
E. Grimm, A. Mazumder, Hua Zhang, S. Rosenberg   +3 more
semanticscholar   +1 more source

PBK/TOPK: A Therapeutic Target Worthy of Attention

Cells, 2021
Accumulating evidence supports the role of PDZ-binding kinase (PBK)/T-lymphokine-activated killer-cell-originated protein kinase (TOPK) in mitosis and cell-cycle progression of mitotically active cells, especially proliferative malignant cells.
Ziping Han, Lingzhi Li, Yuyou Huang, Haiping Zhao, Yumin Luo   +4 more
doaj   +1 more source

The LIN28B–let‐7–PBK pathway is essential for group 3 medulloblastoma tumor growth and survival

Molecular Oncology, 2023
Children with Group 3 medulloblastoma (G3 MB) have a very poor prognosis, and many do not survive beyond 5 years after diagnosis. A factor that may contribute to this is the lack of available targeted therapy.
Shubin W. Shahab, Christianna M. Roggeveen, Jiarong Sun, Haritha Kunhiraman, Leon F. McSwain, Kyle Juraschka, Sachin A. Kumar, Olivier Saulnier, Michael D. Taylor, Matthew Schniederjan, Robert W. Schnepp, Tobey J MacDonald, Anna Marie Kenney   +12 more
doaj   +1 more source

Tripartite antigen-agnostic combination immunotherapy cures established poorly immunogenic tumors

Journal for ImmunoTherapy of Cancer, 2022
Background Single-agent immunotherapy has shown remarkable efficacy in selected cancer entities and individual patients. However, most patients fail to respond.
Reinhard Büttner, Khosro Hekmat, David Kirsch, Michael Hallek, Birgit Gathof, Jana Fassunke, Asmae Gassa, Hakan Alakus, Sven Borchmann, Carolin Selenz, Mia Lohmann, Hanna Ludwig, Johannes Brägelmann, Philipp Lohneis, Lydia Meder, Julia Mattlener, Sara Breid, Marieke Nill, Amy J. Wisdom, Anik Compes, H. Christian Reinhardt, Roland T. Ullrich   +21 more
doaj   +1 more source

Lymphokine-activated killer cell phenomenon. II. Precursor phenotype is serologically distinct from peripheral T lymphocytes, memory cytotoxic thymus-derived lymphocytes, and natural killer cells

Journal of Experimental Medicine, 1983
Culture of human peripheral blood lymphocytes (PBL) in partially purified and lectin-free interleukin 2 results in the generation of cytotoxic effector cells which have the unique property of lysing natural killer (NK)-resistant fresh human tumor cells ...
E. Grimm, K. Ramsey, A. Mazumder, Debra J. Wilson, J. Djeu, S. Rosenberg   +5 more
semanticscholar   +1 more source

Present and future of allogeneic natural killer cell therapy

Frontiers in Immunology, 2015
Natural killer (NK) cells are innate lymphocytes that are capable of eliminating tumor cells and are therefore used for cancer therapy. Although many early investigators used autologous NK cells, including lymphokine-activated killer cells, the clinical ...
Okjae eLim, Mi Young eJung, Yu Kyeong eHwang, Eui-Cheol eShin   +3 more
doaj   +1 more source

Lymphokine-activated killer cell phenomenon. III. Evidence that IL-2 is sufficient for direct activation of peripheral blood lymphocytes into lymphokine-activated killer cells

Journal of Experimental Medicine, 1983
Purified interleukin 2 (IL-2) was found to be sufficient for direct activation of peripheral blood lymphocytes into lymphokine-activated killer (LAK) cells.
E. A. Grimm, R J Robb, J. A. Roth, L M Neckers, L B Lachman, D J Wilson, S. A. Rosenberg   +6 more
semanticscholar   +1 more source

Bcl-2 expression in target cells leads to functional inhibition of caspase-3 protease family in human NK and lymphokine-activated killer cell granule-mediated apoptosis.

Journal of Immunology, 1997
In the granule exocytosis pathway of cell-mediated cytotoxicity, rapid apoptotic nuclear damage in target cells has been unequivocally linked to granzyme B activity.
C. Renvoizé, R. Roger, N. Moulian, Jacques Bertoglio, J. Bréard   +4 more
semanticscholar   +1 more source

The Murine Nonclassical Class I Major Histocompatibility Complex–like CD1.1 Molecule Protects Target Cells from Lymphokine-activated Killer Cell Cytolysis

Journal of Experimental Medicine, 1999
Classical class I major histocompatibility complex (MHC) molecules, as well as the nonclassical class I histocompatibility leukocyte antigen (HLA)-E molecule, can negatively regulate natural killer (NK) cell cytotoxicity through engagement of NK ...
C. Chang, L. Brossay, M. Kronenberg, K. Kane   +3 more
semanticscholar   +1 more source

Mechanism of pentoxifylline mediated down-regulation of killer lineage cell functions

Mediators of Inflammation, 1993
The authors reported recently that endotoxaemia mediated elevated levels of tumour necrosis factor (TNF-α) and interleukin-1α (IL-1α) were involved in the pathophysiology of acute heat stroke patients. Pentoxifylline (PTX) is known to modulate neutrophil
R. S. Parhar, P. Ernst, K. Sheth, M. Einspenner, S. Al-Sedairy   +4 more
doaj   +1 more source