Results 31 to 40 of about 42,543 (244)

CD8⁺, HLA-unrestricted, cytotoxic T-lymphocyte line against malignant melanoma

Journal of Translational Medicine, 2005
A CD8+ cytotoxic T lymphocyte (CTL) line was derived from the peripheral blood mononuclear cells of a patient with primary melanoma. The CD8+ CTL line specifically lysed the autologous primary melanoma cells and not the natural killer cell-sensitive K562
Guerry DuPont, Caputo Laura, Somasundaram Rajasekharan, Herlyn Dorothee   +3 more
doaj   +1 more source

A Review of Immunotherapeutic Strategies in Canine Malignant Melanoma

Veterinary Sciences, 2019
In dogs, melanomas are relatively common tumors and the most common form of oral malignancy. Biological behavior is highly variable, usually aggressive, and frequently metastatic, with reported survival times of three months for oral or mucosal melanomas
Ramón M. Almela, Agustina Ansón
doaj   +1 more source

The potential of cannabinoids in the treatment of lung cancer

Journal of Education, Health and Sport, 2022
Introduction: Lung cancer is the number-one cause of death due to neoplasms worldwide. The 5-year overall survival rate is only 22%. In advanced stages, the therapeutic options are limited to chemotherapy, radiotherapy, molecularly targeted therapy and ...
Małgorzata Drozd, Paweł Marzęda, Jakub Czarnota, Michał Dobrzyński, Tomasz Skubel, Iga Dudek, Natalia Rybak   +6 more
doaj   +1 more source

Canine melanoma: A review of diagnostics and comparative mechanisms of disease and immunotolerance in the era of the immunotherapies

Frontiers in Veterinary Science, 2023
Melanomas in humans and dogs are highly malignant and resistant to therapy. Since the first development of immunotherapies, interest in how the immune system interacts within the tumor microenvironment and plays a role in tumor development, progression ...
Valentina B. Stevenson, Shawna Klahn, Shawna Klahn, Tanya LeRoith, William R. Huckle   +4 more
doaj   +1 more source

Ex vivo-expanded highly purified natural killer cells in combination with temozolomide induce antitumor effects in human glioblastoma cells in vitro.

PLoS ONE, 2019
Glioblastoma is the leading malignant glioma with a poor prognosis. This study aimed to investigate the antitumor effects of natural killer cells in combination with temozolomide as the standard chemotherapeutic agent for glioblastoma.
Yoshitaka Tanaka, Tsutomu Nakazawa, Mitsutoshi Nakamura, Fumihiko Nishimura, Ryosuke Matsuda, Koji Omoto, Yoichi Shida, Toshiharu Murakami, Ichiro Nakagawa, Yasushi Motoyama, Hiromichi Morita, Takahiro Tsujimura, Hiroyuki Nakase   +12 more
doaj   +1 more source

Overexpression of PBK/TOPK relates to poor prognosis of patients with breast cancer: a retrospective analysis

World Journal of Surgical Oncology, 2022
Background PDZ-binding kinase/T-lymphokine-activated killer cell-derived protein kinase (PBK/TOPK) is a potential prognostic indicator for patients with breast cancer.
Liang Qiao, Jinling Ba, Jiping Xie, Ruiping Zhu, Yi Wan, Min Zhang, Zeyu Jin, Zicheng Guo, Jiaxuan Yu, Sijing Chen, Yongqiang Yao   +10 more
doaj   +1 more source

Interleukin 4 (B cell stimulatory factor 1) can mediate the induction of lymphokine-activated killer cell activity directed against fresh tumor cells

Journal of Experimental Medicine, 1987
Interleukin 4 (IL-4) expresses multiple biologic activities, including B cell, mast cell, and T cell stimulation. We showed that the incubation of resting splenocytes from C57BL/6 mice solely in purified native or recombinant mouse IL-4 results in the ...
J. Mulé, Craig A. Smith, S. A. Rosenberg   +2 more
semanticscholar   +1 more source

Regulatory effects of lipoprotein lipase on proliferative and cytotoxic activity of NK cells

Journal of Lipid Research, 1996
Lipoprotein lipase (LPL) induced, in a dose-dependent fashion, a 2-fold and 11-fold increase in the proliferative response of peripheral blood lymphocytes (PBL) at 48 and 72 h, respectively; a 4- and 12-fold increase in natural killer (NK) cells ...
J B De Sanctis, I Blanca, N E Bianco
doaj   +1 more source

Adoptive Cell Therapies for Glioblastoma

Frontiers in Oncology, 2013
Glioblastoma (GBM) is the most common and most aggressive primary brain malignancy and, as it stands, is virtually incurable. With the current standard-of-care, maximum feasible surgical resection followed by radical radiotherapy and adjuvant ...
Kevin James Bielamowicz, Kevin James Bielamowicz, Kevin James Bielamowicz, Kevin James Bielamowicz, Shumaila eKhawja, Nabil eAhmed, Nabil eAhmed, Nabil eAhmed, Nabil eAhmed   +8 more
doaj   +1 more source

Flowcytometry – A rapid tool to correlate functional activities of human peripheral blood lymphocytes with their corresponding phenotypes after in vitro stimulation.

BMC Immunology, 2002
Background While dealing with mixed in vitro lymphocyte cultures one is faced with the problem of relative contributions of different populations to the activity being studied.
Narayanan PR, Nirmala R
doaj   +1 more source