Results 41 to 50 of about 16,485 (256)

Induction of lymphokine-activated killer activity in rat splenocyte cultures: The importance of 2-mercaptoethanol and indomethacin [PDF]

, 1991
The role of 2-mercaptoethanol and indomethacin in the induction of lymphokine-activated killer (LAK) activity by interleukin-2 (IL-2) in rat splenocyte cultures was investigated.
A Nii, AB Peck, Alexander M. M. Eggermont, Andreas Marinelli, C Chen, C Patrono, Cornelis J. H. van de Velde, D Atluru, D Metcalf, D Metcalf, E Katz-Heber, EA Grimm, Emile de Heer, FJ Ramsdell, Gert Jan Fleuren, H Lemke, H Ohmori, H Watanabe, JD Broome, JJ Mulé, JR Ortaldo, KH Leung, LS Manning, M Honda, M Hoyer, MD Roth, MG Goodman, MJ Brunda, MW Fanger, N Obiri, NL Vujanovic, NL Vujanovic, Peter J. K. Kuppen, RE Click, RE Longley, RL Moldwin, S Sone, SM Singh, W Dröge   +38 more
core   +1 more source

Lymphokine-activated killer cells. Analysis of progenitors and effectors. [PDF]

The Journal of experimental medicine, 1986
IL-2 has been examined for its ability to regulate lymphokine-activated killer (LAK) activity. IL-2 is a potent activator of cytolytic activity against a wide array of tumor cells, including those from fresh autologous and allogeneic tumors. Using subpopulations of lymphoid cells that were separated on Percoll density gradients, and subsequently ...
Anna T. Mason, R Overton, John R. Ortaldo   +2 more
openaire   +3 more sources

Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles. [PDF]

, 1996
The killer cell inhibitory receptors (KIRs) are surface glycoproteins expressed by natural killer (NK) and T cells that specifically recognize defined groups of polymorphic human histocompatibility leukocyte antigen (HLA) class I molecules.
Chang, C, D'Andrea, A, Lanier, LL, Phillips, JH   +3 more
core  

The Heterogeneity of Target Recognition by Lymphokine‐activated Killer Precursor Cells [PDF]

Japanese Journal of Cancer Research, 1990
Lymphokine‐activated killer (LAK) cells were generated from peripheral blood lymphocytes (PBL) that were depleted of mature cytotoxic natural killer (NK) cells. PBL NK activity was abolished by pretreatment of effector cells with the toxic lysosomotropic agent l‐leucine methyl ester (LME) or by depletion of effector cells by K562 monolayer absorption ...
Ibayashi, Yukihiro, Gray, J Dixon, Golub, Sidney H, Daibo, Masahiko, Yamaki, Toshiaki, Kawahara, Takahisa, Kubota, Tsukasa, Hashi, Kazuo   +7 more
openaire   +5 more sources

Continuous Indomethacin and Ranitidine with Interleukin-2 in Advanced Renal Carcinoma and Melanoma: A Preliminary Report

Canadian Journal of Infectious Diseases, 1992
Experimental work has shown that during the development of tumours, host macrophages can deactivate natural killer cells and suppress lymphokine-activated killer cell development, apparently through prostaglandin E2 production.
Wilson C Mertens, Vivien HC Bramwell, Peeyush K Lala, Diponkar Banerjee, Femida Gwadry-Sridhar, Walter Romano   +5 more
doaj   +1 more source

The mechanisms by which polyamines accelerate tumor spread

Journal of Experimental & Clinical Cancer Research, 2011
Increased polyamine concentrations in the blood and urine of cancer patients reflect the enhanced levels of polyamine synthesis in cancer tissues arising from increased activity of enzymes responsible for polyamine synthesis. In addition to their de novo
Soda Kuniyasu
doaj   +1 more source

Interleukin 2 activation of natural killer cells rapidly induces the expression and phosphorylation of the Leu-23 activation antigen. [PDF]

, 1988
IL-2 potentiates both growth and cytotoxic function of T lymphocytes and NK cells. Resting peripheral blood NK cells can respond directly to rIL-2, without requirement for accessory cells or cofactors, and enhanced cytotoxicity can be measured within a ...
Barney, C, Buck, DW, Ding, A, Evans, E, Lanier, LL, Phillips, JH, Rhodes, L   +6 more
core  

Interleukin-7 Induces Differential Lymphokine-Activated Killer Cell Activity Against Human Melanoma Cells, Keratinocytes, and Endothelial Cells [PDF]

, 1994
To assess the potential role of interleukin (IL)-7 in immunotherapy of human malignant melanoma, we have examined the lymphokine-activated killer (LAK) cell sensitivity of four human melanoma cell lines against LAK cells generated by IL-7 or IL-2.
Alderson, Amador, Ariba, Armitage, Beate M Czarnetzki, Bertagnolli, Boukamp, Chazen, Conover, Dirk Schadendorf, Fletcher, Greene, Grimm, Heo, Hickman, Houghton, Kalish, Kozeny, Londei, Lotze, Lotze, Lynch, Markus Böhm, Mosman, Mosman, Namen, Naume, Ognibene, Okazaki, Peter Möller, Phillips, Rayner, Rosenberg, Rosenstein, Schadendorf, Stötter, Symington, Thomas Grünewald, West   +38 more
core   +1 more source

Biological processes and factors involved in soft and hard tissue healing

Periodontology 2000, Volume 97, Issue 1, Page 16-42, February 2025.
Abstract Wound healing is a complex and iterative process involving myriad cellular and biologic processes that are highly regulated to allow satisfactory repair and regeneration of damaged tissues. This review is intended to be an introductory chapter in a volume focusing on the use of platelet concentrates for tissue regeneration.
Mark Bartold, Saso Ivanovski
wiley   +1 more source

Natural killer (NK) and lymphokine-activated killer (LAK) cell functions from healthy dogs and 29 dogs with a variety of spontaneous neoplasms [PDF]

, 2018
To investigate natural killer (NK) and lymphokine-activated killer (LAK) cell functions from 10 healthy dogs and 29 dogs with a variety of spontaneous neoplasms, large granular lymphocytes (LGLs) from blood samples were separated by a 58.5% Percoll ...
Burkhardt, Eberhard, Failing, Klaus, Funk, Jürgen, Schmitz, Gabriele   +3 more
core