Results 51 to 60 of about 16,485 (256)

Lymphokine‐activated killer cell and natural killer cell activities in patients with systemic sclerosis [PDF]

Arthritis & Rheumatism, 1992
AbstractObjective. To determine the ability of T lymphocytes and natural killer (NK) cells from patients with systemic sclerosis (SSc) to respond to cytokines and to generate immune effector cells.Methods. The numbers and percentages of peripheral blood T and NK cells were examined by 2‐color flow cytometry, and NK and lymphokine‐activated killer (LAK)
Diana Friberg, Theresa L. Whiteside, Robert B. Buckingham, Thomas V. Kantor, Thomas A. Medsger   +4 more
openaire   +3 more sources

Designing a Resilient Controller for Cancer Immunotherapy: Application to a Fractional‐Order Tumour‐Immune Model

IET Systems Biology, Volume 19, Issue 1, January/December 2025.
In this paper, we propose a robust control method for the automatic treatment of targeted anti‐angiogenic molecular therapy based on multi‐input multi‐output (MIMO) nonlinear fractional and non‐fractional models using the backstepping (BS) approach.
Mohamadreza Homayounzade, Shayan Sajadian   +1 more
wiley   +1 more source

Loss of the Cyclin-Dependent Kinase Inhibitor 1 in the Context of Brachyury-Mediated Phenotypic Plasticity Drives Tumor Resistance to Immune Attack

Frontiers in Oncology, 2018
The acquisition of mesenchymal features by carcinoma cells is now recognized as a driver of metastasis and tumor resistance to a range of anticancer therapeutics, including chemotherapy, radiation, and certain small-molecule targeted therapies.
Duane H. Hamilton, Kristen K. McCampbell, Claudia Palena   +2 more
doaj   +1 more source

Developmental and Anatomical Patterns Of IL-2 Gene Expression in Vivo in The Murine Thymus [PDF]

, 1993
Interleukin-2 (IL-2) is a potent growth factor that mature T lymphocytes synthesize and use as a proliferation signal. Much controversy has arisen concerning whether it is used to drive the extensive proliferation of immature pre-T cells in the thymus ...
Rothenberg, Ellen V., Yang-Snyder, Julia A.   +1 more
core   +3 more sources

Current status of endoscopic ultrasound‐guided antitumor treatment for pancreatic cancer

Digestive Endoscopy, Volume 37, Issue 1, Page 18-28, January 2025.
Endoscopic ultrasound (EUS) was developed in the 1990s and has significantly transformed pancreatic tumor diagnosis. Subsequently, EUS has rapidly shifted from being a purely diagnostic procedure to being used in a wide range of interventional procedures.
Kazuyuki Matsumoto, Hironari Kato, Koichiro Tsutsumi, Motoyuki Otsuka   +3 more
wiley   +1 more source

Mannan-Binding Lectin Regulates Inflammatory Cytokine Production, Proliferation, and Cytotoxicity of Human Peripheral Natural Killer Cells

Mediators of Inflammation, 2019
Natural killer (NK) cells represent the founding members of innate lymphoid cells (ILC) and play critical roles in inflammation and the immune response. NK cell effector functions are regulated and fine-tuned by various immune modulators.
Jia Zhou, Mengyao Hu, Jie Li, Yan Liu, Jialiang Luo, Liyun Zhang, Xiao Lu, Daming Zuo, Zhengliang Chen   +8 more
doaj   +1 more source

Comprehensive Analysis Based on Genes Associated With Cuproptosis, Ferroptosis, and Pyroptosis for the Prediction of Diagnosis and Therapies in Coronary Artery Disease

Cardiovascular Therapeutics, Volume 2025, Issue 1, 2025.
Coronary artery disease (CAD) is a complex condition influenced by genetic factors, lifestyle, and other risk factors that contribute to increased mortality. This study is aimed at evaluating the diagnostic potential of genes associated with cuproptosis, ferroptosis, and pyroptosis (CFP) using network modularization and machine learning methods.
Yongyi Zhang, Zhehan Guo, Renkui Lai, Xu Zou, Liuling Ma, Tianjin Cai, Jingyi Huang, Wenxiang Huang, Bingcheng Zou, Jinming Zhou, Jinxin Li, Muhammad Riaz   +11 more
wiley   +1 more source

Research progress of adoptive cell therapy in malignant glioma

Chinese Journal of Contemporary Neurology and Neurosurgery, 2016
Malignant glioma is the most common malignant tumor of central nervous system (CNS). Surgery is the main treatment method, supplemented by radiation and chemotherapy.
Meng LI
doaj  

Evaluating the cytotoxicity of innate immune effector cells using the GrB ELISPOT assay

Journal of Translational Medicine, 2004
Background This study assessed the Granzyme B (GrB) ELISPOT as a viable alternative to the 51Cr-release assay for measuring cytotoxic activity of innate immune effector cells.
Baseler Michael, Burkett Mark W, Strobl Susan L, Kuhns Douglas B, Sayers Thomas, Shafer-Weaver Kimberly A, Malyguine Anatoli   +6 more
doaj   +1 more source

TIL Therapy in Lung Cancer: Current Progress and Perspectives

Advanced Science, Volume 11, Issue 46, December 11, 2024.
Unveiling the promise of Tumor‐Infiltrating Lymphocytes (TIL) therapy for lung cancer treatment. This review introduces why TIL therapy is suitable for lung cancer, delves into its historical and clinical developments, and discusses methods for identifying tumor‐recognizing TILs and optimizing TIL composition.
Weilei Hu, Yifei Bian, Hongbin Ji
wiley   +1 more source