Results 61 to 70 of about 42,543 (244)

Evaluating the cytotoxicity of innate immune effector cells using the GrB ELISPOT assay

Journal of Translational Medicine, 2004
Background This study assessed the Granzyme B (GrB) ELISPOT as a viable alternative to the 51Cr-release assay for measuring cytotoxic activity of innate immune effector cells.
Baseler Michael, Burkett Mark W, Strobl Susan L, Kuhns Douglas B, Sayers Thomas, Shafer-Weaver Kimberly A, Malyguine Anatoli   +6 more
doaj   +1 more source

Augmentation by anti-T3 antibody of the lymphokine-activated killer cell-mediated cytotoxicity.

Journal of Immunology, 1988
This study showed that a mAb (145-2C11) against the T3 epsilon-chain of the TCR complex augmented the cytotoxic activity of the lymphokine-activated killer (LAK) effectors.
C. Ting, M. Hargrove, Y. Yun
semanticscholar   +1 more source

Current status of endoscopic ultrasound‐guided antitumor treatment for pancreatic cancer

Digestive Endoscopy, Volume 37, Issue 1, Page 18-28, January 2025.
Endoscopic ultrasound (EUS) was developed in the 1990s and has significantly transformed pancreatic tumor diagnosis. Subsequently, EUS has rapidly shifted from being a purely diagnostic procedure to being used in a wide range of interventional procedures.
Kazuyuki Matsumoto, Hironari Kato, Koichiro Tsutsumi, Motoyuki Otsuka   +3 more
wiley   +1 more source

Natural killer and lymphokine activated killer cell functions in Hodgkin's disease [PDF]

British Journal of Cancer, 1990
We report the natural killer (NK) and lymphokine activated killer (LAK) cell activities in peripheral blood lymphocytes (PBL) from untreated patients with Hodgkin's disease (HD) and from healthy donors. The frequency of LAK cell precursors was also studied using limiting dilution analysis (LDA).
N, Rajaram, R J, Tatake, S H, Advani, S G, Gangal   +3 more
openaire   +2 more sources

Comprehensive Analysis Based on Genes Associated With Cuproptosis, Ferroptosis, and Pyroptosis for the Prediction of Diagnosis and Therapies in Coronary Artery Disease

Cardiovascular Therapeutics, Volume 2025, Issue 1, 2025.
Coronary artery disease (CAD) is a complex condition influenced by genetic factors, lifestyle, and other risk factors that contribute to increased mortality. This study is aimed at evaluating the diagnostic potential of genes associated with cuproptosis, ferroptosis, and pyroptosis (CFP) using network modularization and machine learning methods.
Yongyi Zhang, Zhehan Guo, Renkui Lai, Xu Zou, Liuling Ma, Tianjin Cai, Jingyi Huang, Wenxiang Huang, Bingcheng Zou, Jinming Zhou, Jinxin Li, Muhammad Riaz   +11 more
wiley   +1 more source

Specific immunotherapy in renal cancer: a systematic review

Therapeutic Advances in Urology, 2017
Background: Renal cell cancer (RCC) is the tenth most common malignancy in adults. In recent years, several approaches of active and passive immunotherapy have been studied extensively in clinical trials of patients with RCC.
Armin Hirbod-Mobarakeh, Hesam Addin Gordan, Zahra Zahiri, Mohammad Mirshahvalad, Sima Hosseinverdi, Brian I. Rini, Nima Rezaei   +6 more
doaj   +1 more source

TIL Therapy in Lung Cancer: Current Progress and Perspectives

Advanced Science, Volume 11, Issue 46, December 11, 2024.
Unveiling the promise of Tumor‐Infiltrating Lymphocytes (TIL) therapy for lung cancer treatment. This review introduces why TIL therapy is suitable for lung cancer, delves into its historical and clinical developments, and discusses methods for identifying tumor‐recognizing TILs and optimizing TIL composition.
Weilei Hu, Yifei Bian, Hongbin Ji
wiley   +1 more source

COX‐2 in lung cancer: Mechanisms, development, and targeted therapies

Chronic Diseases and Translational Medicine, Volume 10, Issue 4, Page 281-292, December 2024.
COX‐2 functions in the tumor microenvironment. Abstract Lung cancer (LC) is the leading cause of cancer‐related death worldwide, with non‐small cell lung cancer (NSCLC) comprising 85% of all cases. COX‐2, an enzyme induced significantly under stress conditions, catalyzes the conversion of free arachidonic acid into prostaglandins.
Xueqi Liu, Junli Zhang, Wenwu Sun, Jianping Cao, Zhuang Ma   +4 more
wiley   +1 more source

Activated endothelial cells resist lymphokine-activated killer cell-mediated injury. Possible role of induced cytokines in limiting capillary leak during IL-2 therapy.

Journal of Immunology, 1989
We previously demonstrated that IL-2 promotes the adhesion of NK cells to endothelial cells (EC) and that EC are readily lysed by lymphokine-activated killer (LAK) cells in vitro, suggesting that cell mediated endothelial injury may contribute to the ...
James W. Mier, E. Brandon, Peter Libby, M. Janicka, Frederick R. Aronson   +4 more
semanticscholar   +1 more source

Mycobacterium tuberculosis: The Mechanism of Pathogenicity, Immune Responses, and Diagnostic Challenges

Journal of Clinical Laboratory Analysis, Volume 38, Issue 23, December 2024.
Mycobacterium tuberculosis acts as the causative agent of human tuberculosis and is regarded as one of the most adaptable human pathogens. M. tuberculosis possesses several virulence factors that help the bacterium evade mucous barriers. The infection caused by M.
Noura Mohammadnabi, Jebreil Shamseddin, Mobina Emadi, Ali Bayat Bodaghi, Mahdieh Varseh, Aref Shariati, Mina Rezaei, Mahsa Dastranj, Abbas Farahani   +8 more
wiley   +1 more source