Characterization of the SARS-CoV-2-Specific T Cell Responses in Rheumatoid Arthritis Subjects Vaccinated for COVID-19 Protection. [PDF]
Eur J ImmunolSARS‐CoV‐2 vaccination in rheumatoid arthritis leads to the development of CD4+ and CD8+ spike‐specific T cell memory, regardless of immunosuppressive therapies, and the number of vaccine injections. CD4−CD8− double‐negative (DN) T cells responded to SARS‐CoV‐2 peptide epitopes and differentiated into CD8+ cytotoxic T cells after stimulation ...
Song J +5 more
europepmc +2 more sources
Decoy Receptors in Autoimmunity: Molecular Guardians and Pathogenic Players in Immune Dysregulation. [PDF]
Mediators InflammAutoimmune disorders encompass a varied range of diseases in which the immune system mistakenly targets and attacks the body’s own tissues. The causes of the conditions are unknown. It is presumed that various genetic, environmental, and immune factors all play a part.
Farahani H +4 more
europepmc +2 more sources
Tocilizumab Dosing for Management of T Cell-Engaging Bispecific Antibody-Related CRS in Patients With R/R B-Cell NHL. [PDF]
Clin Pharmacol TherTocilizumab dosing for management of T cell‐engaging bispecific antibody‐related CRS in patients with R/R B‐cell NHL. The recent surge in T‐cell‐engaging and chimeric antigen receptor (CAR) T‐cell therapies is changing the landscape of cancer therapy.
Jamois C +13 more
europepmc +2 more sources
A Review: Can Cytokines Induce Vascular Inflammation as a Sequela of Viral Infections? [PDF]
Health Sci RepABSTRACT Background and Aim There are many unknown consequences of viral infections. In this piece, we looked at one of these effects that influence the venous system of the body, vasculitis, an inflammation of the blood vessels. Discussion The study illustrates that viral infections attack host cells through viral proteins and surface receptors ...
Deena SA +4 more
europepmc +2 more sources
Allergologia et immunopathologia, 1983 Lymphokines are defined as nonimmunoglobulin secretory products of activated lymphocytes with a wide range of potent physiological effects on inflammation and immune responses. In this review, we summarized the recent development in lymphokine researches, including biochemical and immunological approaches.
K, Okuno, T, Hamaoka
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Identification and antiviral effect of Cherry Valley duck IRF4
Poultry Science, 2022 : Interferon regulatory factor 4 (IRF4) is a multifunctional transcription factor that plays an important regulatory role in the interferon (IFN) signaling.
Xinyu Zhai +8 more
doaj +1 more source
Immunosuppressive and Non-Immunosuppressive Drugs for Heart Xenotransplantation in Humans: Is Europe Ready? [PDF]
XenotransplantationABSTRACT Xenotransplantation is becoming an emerging field of interest for the treatment of end‐stage heart disease. In fact, the shortage of human heart donors in European countries requires the increasing investigation of alternative strategies such as heart xenotransplantation.
Pradegan N +6 more
europepmc +2 more sources
EFFECT OF LYMPHOKINES ON DRUG RESISTANCE OF BREAST TUMOR
Опухоли женской репродуктивной системы, 2014 The paper considers the effect of cytokines isolated from autologous peripheral lymphocytes on the kinetics of breast cancer, which is exhibited by induced apoptosis and inhibited proliferation.
L. T. Alimkhodzhayeva
doaj +1 more source
Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism. [PDF]
, 1990 BALB/c mice infected with Leishmania major develop fatal, progressive disease, despite an immune response characterized by expansion of CD4+ T cells in the draining lymph nodes.
Dawkins, RS +5 more
core +1 more source
Effects of cytokines on the production of lipoprotein lipase in cultured human macrophages.
Journal of Lipid Research, 1990 Macrophages are important cells in the pathogenesis of atherosclerosis because of their tendency to accumulate lipid and become transformed into foam cells.
U Querfeld +6 more
doaj +1 more source