Results 41 to 50 of about 13,416 (164)

COX‐2 in lung cancer: Mechanisms, development, and targeted therapies

Chronic Diseases and Translational Medicine, Volume 10, Issue 4, Page 281-292, December 2024.
COX‐2 functions in the tumor microenvironment. Abstract Lung cancer (LC) is the leading cause of cancer‐related death worldwide, with non‐small cell lung cancer (NSCLC) comprising 85% of all cases. COX‐2, an enzyme induced significantly under stress conditions, catalyzes the conversion of free arachidonic acid into prostaglandins.
Xueqi Liu, Junli Zhang, Wenwu Sun, Jianping Cao, Zhuang Ma   +4 more
wiley   +1 more source

Identification and antiviral effect of Cherry Valley duck IRF4

Poultry Science, 2022
: Interferon regulatory factor 4 (IRF4) is a multifunctional transcription factor that plays an important regulatory role in the interferon (IFN) signaling.
Xinyu Zhai, Tianqi Hong, Tingting Zhang, Bin Xing, Jinchao Wang, Xiuyuan Wang, Runchun Miao, Tianxu Li, Liangmeng Wei   +8 more
doaj  

Mycobacterium tuberculosis: The Mechanism of Pathogenicity, Immune Responses, and Diagnostic Challenges

Journal of Clinical Laboratory Analysis, Volume 38, Issue 23, December 2024.
Mycobacterium tuberculosis acts as the causative agent of human tuberculosis and is regarded as one of the most adaptable human pathogens. M. tuberculosis possesses several virulence factors that help the bacterium evade mucous barriers. The infection caused by M.
Noura Mohammadnabi, Jebreil Shamseddin, Mobina Emadi, Ali Bayat Bodaghi, Mahdieh Varseh, Aref Shariati, Mina Rezaei, Mahsa Dastranj, Abbas Farahani   +8 more
wiley   +1 more source

Influence of dental filling material type on the concentration of interleukin 9 in the samples of gingival crevicular fluid [PDF]

Vojnosanitetski Pregled, 2016
Background/Aim. Several cytokines and lymphokines (IL1β, ENA78, IL6, TNFα, IL8 and S100A8) are expressed during dental pulp inflammation. Analysis of gingival crevicu-lar fluid (GCF) offers a non-invasive means of studying gen-eral host response in oral ...
Stefanović Vladimir, Taso Ervin, Petković-Ćurčin Aleksandra, Đukić Mirjana, Gardašević Milka, Rakić Mia, Xavier Struillou, Jović Milena, Miller Karolina, Stanojević Ivan, Vojvodić Danilo   +10 more
doaj   +1 more source

Pan‐Cancer Analysis of Ezrin: A Comprehensive Examination of Its Prognostic Value and Immunological Implications

Organ Medicine, Volume 1, Issue 2, Page 70-84, December 2024.
This article comprehensively analyzes the pivotal role of ezrin, an ERM protein family member, in diverse tumor types, highlighting its immunomodulatory capabilities and associations with tumor progression, immune cell infiltration, and therapeutic responses.
Ruiqi Chen, Hongbiao Xu, Elfira Jurat, Hewang Huang, Shangwu Yang, Liang Han, Fengyun Wang   +6 more
wiley   +1 more source

A narrative review on the role of magnesium in immune regulation, inflammation, infectious diseases, and cancer

Journal of Health, Population and Nutrition, 2023
Background Magnesium (Mg) has gained much importance recently because of its unique range of biological functions. It is one of the most significant micronutrients in biological systems. This review aims to outline the immune-regulating actions of Mg and
Sumel Ashique, Shubneesh Kumar, Afzal Hussain, Neeraj Mishra, Ashish Garg, B. H. Jaswanth Gowda, Arshad Farid, Gaurav Gupta, Kamal Dua, Farzad Taghizadeh-Hesary   +9 more
doaj   +1 more source

Upscaling Osteoclast Generation by Enhancing Macrophage Aggregation Using Hollow Microgels

Small, Volume 20, Issue 46, November 14, 2024.
This study investigates the potential of high‐throughput droplet microfluidics for microencapsulation of human macrophages in hollow, sacrificial tyramine‐conjugated dextran microgels to facilitate osteoclast formation. Intriguingly, osteoclast formation within these 3D microenvironments is occurring at a significantly higher level compared to the ...
Johanna F.A. Husch, Nuno Araújo‐Gomes, Niels G.A. Willemen, Carla Cofiño‐Fabrés, Nils van Creij, Robert Passier, Jeroen Leijten, Jeroen J. J. P. van den Beucken   +7 more
wiley   +1 more source

Targeting CD25+ lymphoma cells with the antibody–drug conjugate camidanlumab tesirine as a single agent or in combination with targeted agents

British Journal of Haematology, Volume 205, Issue 5, Page 1873-1882, November 2024.
Camidanlumab tesirine is a CD25‐specific antibody‐drug conjugate employing SG3199, a highly cytotoxic DNA minor groove cross‐linking pyrrolobenzodiazepine dimer, with cytotoxic activity in lymphoma cells. The addition of other drugs targeting additional pathways can synergize with camidanlumab tesirine. Created with Biorende.
Filippo Spriano, Chiara Tarantelli, Luciano Cascione, Eugenio Gaudio, Gaetanina Golino, Lorenzo Scalise, Maria Teresa Cacciapuoti, Emanuele Zucca, Anastasios Stathis, Patrick H. Van Berkel, Giorgio Inghirami, Francesca Zammarchi, Francesco Bertoni   +12 more
wiley   +1 more source

Effects of cytokines on the production of lipoprotein lipase in cultured human macrophages.

Journal of Lipid Research, 1990
Macrophages are important cells in the pathogenesis of atherosclerosis because of their tendency to accumulate lipid and become transformed into foam cells.
U Querfeld, JM Ong, J Prehn, J Carty, B Saffari, SC Jordan, PA Kern   +6 more
doaj  

Dynamic changes in macrophage polarization during the resolution phase of periodontal disease

Immunity, Inflammation and Disease, Volume 12, Issue 10, October 2024.
This is the first translational studies to longitudinally assess the M/M2 MΦ profiles before and after therapy in periodontitis subjects and can serve as the first step in examining current treatment strategies to include investigations on the role of macrophage immune mediated regulatory networks governing periodontal disease pathogenesis.
Juhi R. Uttamani, Varun Kulkarni, Araceli Valverde, Raza Ali Naqvi, Thomas Van Dyke, Salvador Nares, Afsar R. Naqvi   +6 more
wiley   +1 more source