Results 61 to 70 of about 11,363 (187)

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

Excited Skin Syndrome (Angry Back), What Do We Know About It? A Review of the Literature

Journal of Cosmetic Dermatology, Volume 25, Issue 2, February 2026.
ABSTRACT Background In 1975, Mitchell brought up a theory that false positive reactions can be due to skin hyperirritability, called it “angry back syndrome” (ABS). The phenomenon is observed in patch testing of patients with several positive patch tests, mostly along with one or more strong reactions.
Amir Mohammad Beyzaee, Howard I. Maibach
wiley   +1 more source

V-region-related and -unrelated immunosupression accompanying infections

Memorias do Instituto Oswaldo Cruz, 1992
This paper discusses current evidence for the relationship between polyclonal lymphocyte activation, specific immunossupression with decreased resistance, and autoimmune pathology, that are all often found associated with infections by a variety of virus,
Mario Arala-Chaves, M. Regina D'Imperio Lima, Antonio Coutinho, Claudia Penna-Rossi, Paola Minoprio   +4 more
doaj   +1 more source

Crosstalk between T lymphocyte and extracellular matrix in tumor microenvironment

Frontiers in Immunology
The extracellular matrix (ECM) is a complex three-dimensional structure composed of proteins, glycans, and proteoglycans, constituting a critical component of the tumor microenvironment.
Die Lv, Yujie Fei, Hongli Chen, Junfeng Wang, Wenwen Han, Bomiao Cui, Yun Feng, Ping Zhang, Jiao Chen   +8 more
doaj   +1 more source

The epigenetic drug Trichostatin A ameliorates experimental autoimmune encephalomyelitis via T cell tolerance induction and impaired influx of T cells into the spinal cord

Neurobiology of Disease, 2017
Multiple sclerosis is a T cell mediated chronic demyelinating disease of the central nervous system. Although currently available therapies reduce relapses, they do not facilitate tolerization of myelin antigen-specific T lymphocytes to ensure prolonged ...
Arathi Jayaraman, Advait Soni, Bellur S. Prabhakar, Mark Holterman, Sundararajan Jayaraman   +4 more
doaj   +1 more source

H1N1 with fatal viral septicemia in a normal child: A case report

Respiratory Medicine Case Reports, 2020
Background: Regardless of the agent, the inflammatory response is interconnected with infection. Mostly the initial response to infection is severe sepsis and characterized by a pro-inflammatory state, which then progresses to an anti-inflammatory state ...
Ahmed Rezk Ahmed, M.D.
doaj   +1 more source

Metabolic Functions and Mechanisms of Selenium, Selenocysteine, and GPX4 Mediated Immune Regulation Through Autophagy in Solid Tumors

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This paper focuses on selenium, selenocysteine, and GPX4, elaborating on their metabolic functions and mechanisms in mediating immune regulation through autophagy in solid tumors. It explores the characteristics of selenium metabolism in tumors and the roles of related enzymes, providing new directions for cancer treatment.
Liang Yang, Yu Jiang, Haoyue Wu, Jinnan Sun, Xinyue Huang, Jingfeng Hong, Bin Zheng, Jinmiao Zhu   +7 more
wiley   +1 more source

Pré-eclâmpsia: estresse oxidativo, inflamação e disfunção endotelial Preeclampsia: oxidative stress, inflammation and endothelial dysfunction

Revista Brasileira de Ginecologia e Obstetrícia, 2010
Pré-eclâmpsia é uma síndrome sistêmica caracterizada por intenso estado inflamatório e antiangiogênico. A fisiopatologia da pré-clâmpsia envolve alterações no processo de invasão trofoblástica, com consequente inadequado suprimento sanguíneo uterino e ...
Leandro Gustavo de Oliveira, Ananth Karumanchi, Nelson Sass   +2 more
doaj   +1 more source

The in Vivo Effects of Lymphokines on Mitotic Activity and Keratinization in Guinea Pig Epidermis [PDF]

, 1981
Lymphokines may alter epidermal growth and differentiation contributing to changes such as acanthosis and hyperkeratosis. The main in vivo effects of lymphokines on epidermal mitotic activity were therefore investigated.
Johnson, Newell W., J. Mark Wilton, Korszun, Anna-Krystyna, Anna-Krystyna Korszun, Wilton, J. Mark, Newell W. Johnson   +5 more
core   +1 more source

An homologous in vitro assay to detect lymphokines released by PHA-activated duck peripheral blood lymphocytes and spleen cells.

, 1997
When stimulated with phytohaemagglutinin duck lymphocytes released lymphokines which were detected by their ability to maintain the proliferation of duck lymphoblasts using an in vitro assay similar to that previously developed with the mammalian system ...
E.M. Bertram, Jilbert, A., I. Kotlarski, Bertram, E., Kotlarski, I., A.R. Jilbert   +5 more
core   +1 more source