Results 51 to 60 of about 9,051 (165)

Metabolic Functions and Mechanisms of Selenium, Selenocysteine, and GPX4 Mediated Immune Regulation Through Autophagy in Solid Tumors

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This paper focuses on selenium, selenocysteine, and GPX4, elaborating on their metabolic functions and mechanisms in mediating immune regulation through autophagy in solid tumors. It explores the characteristics of selenium metabolism in tumors and the roles of related enzymes, providing new directions for cancer treatment.
Liang Yang, Yu Jiang, Haoyue Wu, Jinnan Sun, Xinyue Huang, Jingfeng Hong, Bin Zheng, Jinmiao Zhu   +7 more
wiley   +1 more source

Ultra‐Processed Foods and Markers of Systemic Inflammation in Children

Food Science &Nutrition, Volume 13, Issue 9, September 2025.
Illustration showing the association between ultra‐processed foods intake and systemic inflammation, measured with cytokines levels in children. ABSTRACT Diets high in ultra‐processed foods (UPF) have been associated with negative health outcomes in adults; however, UPF's impact on children's health and their underlying mechanisms remain underexplored,
Camila Awad, Paola Rubilar, Macarena Hirmas‐Adauy, Verónica Iglesias, María Pía Muñoz, Mauricio A. Retamal, Cristóbal Carvajal, Payam Dadvand, Camille Lassale   +8 more
wiley   +1 more source

Accumulation of Oxidized Low-Density Lipoprotein in Psoriatic Skin and Changes of Plasma Lipid Levels in Psoriatic Patients

Mediators of Inflammation, 2007
Background. Psoriasis is a chronic inflammatory skin disease characterized by an accelerated turnover of epidermal cells and an incomplete differentiation in epidermis with lesion. However, the exact etiology of psoriasis is unknown.
Nilgun Solak Tekin, Ishak Ozel Tekin, Figen Barut, Emine Yilmaz Sipahi   +3 more
doaj   +1 more source

Macrophages: Subtypes, Distribution, Polarization, Immunomodulatory Functions, and Therapeutics

MedComm, Volume 6, Issue 8, August 2025.
Macrophages originate from the yolk sac, fetal liver, and bone marrow, differentiating into two main subtypes: M1‐like (proinflammatory) and M2‐like (anti‐inflammatory). These subtypes exhibit high plasticity, allowing them to transform in response to environmental cues or therapeutic interventions.
Mengyuan Peng, Niannian Li, Hongbo Wang, Yaxu Li, Hui Liu, Yanhua Luo, Bao Lang, Weihang Zhang, Shilong Li, Liujun Tian, Bin Liu   +10 more
wiley   +1 more source

Molecular Mechanisms of Chronic Pain and Therapeutic Interventions

MedComm, Volume 6, Issue 8, August 2025.
We offer a comprehensive overview of the distinctive molecular mechanisms underlying nociceptive, neuropathic, and nociplastic pain, including the immune responses, ion channels, monoaminergic imbalance, and neuroinflammation. Subsequently, we summarized the status quo of nociceptive, neuropathic, and nociplastic pain managementmanipulation.
Zhen Li, Xing Li, Jieqiong Liu, Rao Sun, Yingze Ye, Hongbing Xiang, Fang Luo, Shiyong Li, Ailin Luo   +8 more
wiley   +1 more source

V-region-related and -unrelated immunosupression accompanying infections

Memorias do Instituto Oswaldo Cruz, 1992
This paper discusses current evidence for the relationship between polyclonal lymphocyte activation, specific immunossupression with decreased resistance, and autoimmune pathology, that are all often found associated with infections by a variety of virus,
Mario Arala-Chaves, M. Regina D'Imperio Lima, Antonio Coutinho, Claudia Penna-Rossi, Paola Minoprio   +4 more
doaj   +1 more source

Crosstalk between T lymphocyte and extracellular matrix in tumor microenvironment

Frontiers in Immunology
The extracellular matrix (ECM) is a complex three-dimensional structure composed of proteins, glycans, and proteoglycans, constituting a critical component of the tumor microenvironment.
Die Lv, Yujie Fei, Hongli Chen, Junfeng Wang, Wenwen Han, Bomiao Cui, Yun Feng, Ping Zhang, Jiao Chen   +8 more
doaj   +1 more source

The Role of T‐Helper 17 Cells and Regulatory T Cells in Acute Diffuse and Total Alopecia: The Increased Function of Regulatory T Cells May Explain the Favorable Prognosis

The Journal of Dermatology, Volume 52, Issue 7, Page 1138-1145, July 2025.
ABSTRACT Background Acute diffuse and total alopecia (ADTA) is a variant of alopecia areata (AA) that lacks the typical patchy hair loss seen in classical AA and presents with an acute onset of diffuse hair loss. It has a favorable prognosis. Objectives The purpose of this study was to assess the role of T‐helper (Th) 17 cells and regulatory T cells ...
Ji‐Hoon Lim, Da‐Hyun Kang, Haena Moon, Soon‐Hyo Kwon, Bark‐Lynn Lew   +4 more
wiley   +1 more source

The epigenetic drug Trichostatin A ameliorates experimental autoimmune encephalomyelitis via T cell tolerance induction and impaired influx of T cells into the spinal cord

Neurobiology of Disease, 2017
Multiple sclerosis is a T cell mediated chronic demyelinating disease of the central nervous system. Although currently available therapies reduce relapses, they do not facilitate tolerization of myelin antigen-specific T lymphocytes to ensure prolonged ...
Arathi Jayaraman, Advait Soni, Bellur S. Prabhakar, Mark Holterman, Sundararajan Jayaraman   +4 more
doaj   +1 more source

H1N1 with fatal viral septicemia in a normal child: A case report

Respiratory Medicine Case Reports, 2020
Background: Regardless of the agent, the inflammatory response is interconnected with infection. Mostly the initial response to infection is severe sepsis and characterized by a pro-inflammatory state, which then progresses to an anti-inflammatory state ...
Ahmed Rezk Ahmed, M.D.
doaj   +1 more source