Mediators of Inflammation, 2007 Background. Psoriasis is a chronic inflammatory skin disease characterized by an accelerated turnover of epidermal cells and an incomplete differentiation in epidermis with lesion. However, the exact etiology of psoriasis is unknown.
Nilgun Solak Tekin +3 more
doaj +1 more source
Management of intestinal transplantation in humans [PDF]
, 1992 We report here the clinical experience and management guidelines for the nine consecutive cases who received either an isolated small intestinal graft (n = 1) or an intestine liver combination at the University of Pittsburgh, with FK 506 being the basic ...
Abu-Elmagd, K +14 more
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A combination of soluble helper factors bypasses the requirement for stimulator cells and induces nonspecific cytotoxic T cell responses [PDF]
, 1985 The specificity of cytotoxic T lymphocyte (CTL) responses generated in the presence of lymphokines was studied. Thymic responder cells were activated in the presence of stimulator cells that differed in their metabolic activity.
Dröge, W., Falk, Werner, Männel, D. N.
core +1 more source
Molecular Mechanisms of Chronic Pain and Therapeutic Interventions
MedComm, Volume 6, Issue 8, August 2025.We offer a comprehensive overview of the distinctive molecular mechanisms underlying nociceptive, neuropathic, and nociplastic pain, including the immune responses, ion channels, monoaminergic imbalance, and neuroinflammation. Subsequently, we summarized the status quo of nociceptive, neuropathic, and nociplastic pain managementmanipulation.
Zhen Li +8 more
wiley +1 more source
Guinea pigs sublethally infected with aerosolized Legionella pneumophila develop humoral and cell-mediated immune responses and are protected against lethal aerosol challenge. A model for studying host defense against lung infections caused by intracellular pathogens. [PDF]
, 1987 We have employed the guinea pig model of L. pneumophila infection, which mimics Legionnaires' disease in humans both clinically and pathologically, to study humoral and cell-mediated immune responses to L.
Breiman, RF, Horwitz, MA
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Neutrophil and lymphocyte responses to oral Streptococcus in Adamantiades-Behcet's disease [PDF]
, 2005 Immune reactions against microorganisms play an important pathogenic role in Adamantiades-Behçet’s disease (ABD). We had previously obtained Streptococcus sanguinis (strain BD113-20) isolated from the oral cavity of patients with ABD.
Aoki +30 more
core +1 more source
V-region-related and -unrelated immunosupression accompanying infections
Memorias do Instituto Oswaldo Cruz, 1992 This paper discusses current evidence for the relationship between polyclonal lymphocyte activation, specific immunossupression with decreased resistance, and autoimmune pathology, that are all often found associated with infections by a variety of virus,
Mario Arala-Chaves +4 more
doaj +1 more source
T cell-specific suppressor factor(s) with regulatory influence on interleukin 2 production and function [PDF]
, 1982 In this study we report that alloantigen-activated spleen cells produce both amplifying and suppressive factors under the same conditions. Both types of soluble mediators--as detected in different assay systems-- were present in the supernatants of in ...
Koszinowski, Ulrich H., Kramer, M.
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The Journal of Dermatology, Volume 52, Issue 7, Page 1138-1145, July 2025.ABSTRACT Background Acute diffuse and total alopecia (ADTA) is a variant of alopecia areata (AA) that lacks the typical patchy hair loss seen in classical AA and presents with an acute onset of diffuse hair loss. It has a favorable prognosis. Objectives The purpose of this study was to assess the role of T‐helper (Th) 17 cells and regulatory T cells ...
Ji‐Hoon Lim +4 more
wiley +1 more source
Crosstalk between T lymphocyte and extracellular matrix in tumor microenvironment
Frontiers in ImmunologyThe extracellular matrix (ECM) is a complex three-dimensional structure composed of proteins, glycans, and proteoglycans, constituting a critical component of the tumor microenvironment.
Die Lv +8 more
doaj +1 more source