Results 41 to 50 of about 47,605 (283)

Prognostic Value of the Width of Invasion in pT3 Cutaneous Melanomas

International Journal of Translational Medicine, 2023
Intermediate-thickness melanomas display highly variable outcomes influenced by both clinical and histopathological characteristics. This study investigates several clinicopathological prognostic factors for pT3 cutaneous melanomas, focusing on a novel ...
Dana Antonia Țăpoi, Ancuța-Augustina Gheorghișan-Gălățeanu, Laura Maria Gosman, Adrian Vasile Dumitru, Ana Maria Ciongariu, Mariana Costache   +5 more
doaj   +1 more source

Adverse prognostic and predictive significance of low DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in early-stage breast cancers [PDF]

, 2014
Background: DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a serine threonine kinase belonging to the PIKK family (phosphoinositide 3-kinase-like-family of protein kinase), is a critical component of the non-homologous end joining (NHEJ ...
AC Wolff, Andrew R. Green, Arvind Arora, B Salles, C Curtis, Christina Perry, Devika Agarwal, Emad Rakha, ET Shinohara, FM Hsu, Graham Ball, HS Lee, HS Lee, Ian O. Ellis, JA Neal, K Meek, K Soderlund Leifler, L Du, LA Loeb, LA Loeb, LM McShane, M Burg van der, Nicola Thompson, Paul Moseley, R Hill, R Sultana, S Medunjanin, SJ Collis, SL Shao, Srinivasan Madhusudan, Stephen Chan, SY Wang, Tarek Abdel-Fatah, TM Abdel-Fatah, TM Abdel-Fatah, TM Abdel-Fatah, U Moll, W Zhuang, X Kong, X Wang, XD Long, Z Hu   +41 more
core   +1 more source

Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer [PDF]

, 2014
FEN1 has key roles in Okazaki fragment maturation during replication, long patch base excision repair, rescue of stalled replication forks, maintenance of telomere stability and apoptosis.
Abdel-Fatah, Abdel-Fatah, Abdel-Fatah, Abdel-Fatah, Abdel-Fatah, Abhik Mukherjee, Ajit Jadhav, Anton Simeonov, Bergh, Brown, Buterin, Carlos Caldas, Chin, Curtis, David J. Maloney, David M. Wilson, Devika Agarwal, Dorjbal Dorjsuren, Dorjsuren, Graham Ball, Guo, Henneke, Henneke, Hongmao Sun, Hothorn, Ian O. Ellis, Jennifer L. Illuzzi, Kim, Kim, Krause, Kucherlapati, Kucherlapati, Lam, Larsen, Larsen, Liu, McShane, Moggs, Nada Albarakati, Nikolova, Oscar M. Rueda, Paul Moseley, Pawitan, Rachel Abbotts, Roslin Russell, Sato, Schultz-Norton, Shen, Singh, Srinivasan Madhusudan, Stephen Chan, Sultana, Tarek M.A. Abdel-Fatah, van Pel, Vivek Mohan, Wu, Xu, Yang, Zheng, Zheng   +59 more
core   +2 more sources

Risk factors for lymph node metastasis in early gastric cancer patients: Report from Eastern Europe country– Lithuania

BMC Surgery, 2017
Background Current risk factors for lymph node metastasis in early gastric cancer have been primarily determined in Asian countries; however their applicability to Western nations is under discussion.
Rimantas Bausys, Augustinas Bausys, Indre Vysniauskaite, Kazimieras Maneikis, Dalius Klimas, Martynas Luksta, Kestutis Strupas, Eugenijus Stratilatovas   +7 more
doaj   +1 more source

A novel methodology for in vivo endoscopic phenotyping of colorectal cancer based on real-time analysis of the mucosal lipidome: a prospective observational study of the iKnife [PDF]

, 2016
Background: This pilot study assessed the diagnostic accuracy of rapid evaporative ionization mass spectrometry (REIMS) in colorectal cancer (CRC) and colonic adenomas. Methods: Patients undergoing elective surgical resection for CRC were recruited at St.
Alexander, J, Balog, J, Darzi, A, Gildea, L, Goldin, R, Hoare, J, Kinross, J, Kontovounisios, C, McKenzie, J, Muirhead, L, Nicholson, J, Rasheed, S, Scott, A, Speller, A, Takats, Z, Teare, J, Tekkis, P, Veselkov, K   +17 more
core   +1 more source

Adjuvant radiotherapy after radical cystectomy for patients with muscle invasive bladder cancer : a phase II trial [PDF]

, 2017
Background: Neo-adjuvant chemotherapy followed by radical cystectomy with extended pelvic lymph node dissection is considered to be the treatment of choice for patients with muscle invasive bladder cancer (MIBC).
De Meerleer, Gert, Decaestecker, Karel, Dirix, Piet, Fonteyne, Valerie, Junius, Sara, Ost, Piet, Rammant, Elke, Swimberghe, Martijn   +7 more
core   +1 more source

Influence of perineural invasion in predicting overall survival and disease-free survival in patients With locally advanced gastric cancer [PDF]

, 2017
Background The aim of the present study was to evaluate the prognostic significance of perineural invasion (PNI) in locally advanced gastric cancer patients who underwent D2 gastrectomy and adjuvant chemotherapy.
Aurello, P, Berardi, G, Giulitti, D, Laracca, Gg, Pilozzi, E, Ramacciato, G., RAMPIONI VINCIGUERRA, GIAN LUCA, Socciarelli, F, Tierno, Sm   +8 more
core   +1 more source

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

Characterization of Microplastics in Human Gastric Cancer and Control Tissues and Analysis of Associated Genetic Features

Advanced Healthcare Materials, EarlyView.
This study characterizes the presence of microplastics in human normal gastric, para‐tumor, and gastric tumor tissue and confirms the association between microplastic exposure and lymph node metastasis in gastric cancer. This study explores the transcriptomic changes induced by microplastic exposure, laying the foundation for further investigation into
Liqiao Chen, Jialin Li, Yan Wu, Han Bao, Xuesong Yang, Guoqing Lv, Ke Ji, Ji Zhang, Xiaojiang Wu, Kai Zhou, Jieli Xu, Jiatian Tang, Xiyuan Han, Anqiang Wang   +13 more
wiley   +1 more source

Lymphovascular Invasion in Colorectal Cancer: An Interobserver Variability Study [PDF]

, 2014
Background: Lymphovascular invasion (LVI) in colorectal cancer (CRC) is considered a strong stage-independent prognostic factor and influences decisions regarding adjuvant chemotherapy in patients with Stage II tumors.
Harris, Elizabeth I., Lauwers, Gregory Y., Lewin, David N., Revetta, Frank, Shakhtour, Bashar, Shyr, Yu, Srivastava, Amitabh, Wang, Hanlin L., Washington, Mary K.   +8 more
core   +1 more source