Results 51 to 60 of about 47,605 (283)

ZFPL1 Promotes Colorectal Cancer Progression by Stabilizing ASS1 to Drive the Urea Cycle and M2 Macrophage‐Mediated Metastatic Colonization

Advanced Science, EarlyView.
ScRNA‐seq reveals ZFPL1‐specific enrichment in malignant CRC cells. Mechanistically, ZFPL1 stabilizes ASS1 by blocking K57 ubiquitination, activating urea cycle metabolism to drive progression. ZFPL1 inhibition reprograms the TME by suppressing M2 macrophages polarization and promotion M1 macrophages, thereby inhibiting CRC liver metastasis ...
Xiangjun Qian, Chenxi Xie, Beilin Zhang, Hengsong Cao, Zhengqing Lu, Li Liu, Shipeng Dai, Xiaoqian Wang, Xiaokai Zhang, Feng Han, Yanyan Liu, Haibo Yu, Weiwei Tang, Jinxue Zhou, Xiaopei Hao   +14 more
wiley   +1 more source

Risk factors of synchronous inguinal lymph nodes metastasis for lower rectal cancer involving the anal canal. [PDF]

PLoS ONE, 2014
PURPOSE: The aim of the study is to identify the risk factors of synchronous ILN metastasis for lower rectal cancer involving the anal canal. METHODS: Patients with lower rectal cancer who underwent radical resection at the Fudan University Shanghai ...
Renjie Wang, Peng Wu, Debing Shi, Hongtu Zheng, Liyong Huang, Weilie Gu, Ye Xu, Sanjun Cai, Guoxiang Cai   +8 more
doaj   +1 more source

An evidence-based treatment algorithm for colorectal polyp cancers:results from the Scottish Screen-detected Polyp Cancer Study (SSPoCS) [PDF]

, 2016
Objectives: Colorectal polyp cancers present clinicians with a treatment dilemma. Decisions regarding whether to offer segmental resection or endoscopic surveillance are often taken without reference to good quality evidence. The aim of this study was to
Aitken, E., Carey, F. A., Forrest, C., Knight, K., Mackay, C. D., Mansouri, D., McFarlane, G., McKay, A., Mulholland, C., Nair, H., Neo, Y. N., On, J., Parnaby, C. N., Ramsay, G., Richards, C. H., Robertson, J. H., Smith, D., Speake, D., Steele, R. J. C., Ventham, N. T., Wilson, M.   +20 more
core   +2 more sources

A Unique Chimeric RNA: ERCC1‐iASPP Drives Benzo[a]pyrene‐Induced Lung Carcinogenesis via Dual Coding and Non‐Coding Mechanisms

Advanced Science, EarlyView.
The chimeric RNA ERCC1‐iASPP possesses dual coding and non‐coding functions, synergistically accelerating the process of cellular malignant transformation. Abstract Genetic variation at 19q13.3 critically modulates chemical carcinogen‐induced lung carcinogenesis, particularly in mediating the activity of benzo[a]pyrene (B[a]P), a major polycyclic ...
Mingming Shan, Mingyang Xiao, Liang Zhang, Shen Wang, Jiahang Wu, Kang Cao, Yujin Li, Guopei Zhang, Junwei Xie, Xiaobo Lu   +9 more
wiley   +1 more source

Predictive Factors Affecting Axillary Lymph Node Metastasis in Breast Cancer

Haseki Tıp Bülteni, 2019
Aim:The status of axillary lymph node metastasis (ALNM) at diagnosis has been considered as one of the most important prognostic factors for overall and disease-free survival in patients with breast cancer. Determination of breast cancer patients at risk
Suat Benek, Cihad Tatar
doaj   +1 more source

Laeverin is Cell‐Surface Target for Liquid‐Phase Metastasizing Cancer Cells

Advanced Science, EarlyView.
This study revealed that epithelial cancer cells in the floating phase induce the expression of laeverin (LVRN) that is a trophoblast‐specific and cell‐surface immunoregulatory factor and showed that anti‐LVRN ADC is a promising agent that can attack cancer cells in the metastatic liquid phase and block further distant metastasis.
Haruki Kasama, Yuya Sakai, Kyosuke Kagami, Takashi Iizuka, Tatsuhito Kanda, Takuma Suzuki, Kayo Kayahashi, Masanori Ono, Tomoko Fujiwara, Shintaro Yagi, Noriyuki Inaki, Isao Matsumoto, Rena Yamazaki, Kaoru Abiko, Noriomi Matsumura, Akira Hattori, Takiko Daikoku, Hiroshi Fujiwara   +17 more
wiley   +1 more source

Correlation between Histopathological Features and Clinical Outcomes in Patients with Oral Squamous Cell Carcinoma

Journal of Pharmacy and Bioallied Sciences
Introduction: Oral squamous cell carcinoma (OSCC) is a prevalent malignancy, with histopathological features playing a crucial role in predicting clinical outcomes.
Shamita Tiwari, Saurabh Shekhar, Oruganti V. Ramanand, Pallavi Mishra, Anish Nelson, Kiran S. Shankar, Riddhima Mathur   +6 more
doaj   +1 more source

Microinvasive carcinoma of the cervix [PDF]

, 2004
BACKGROUND: Superficially invasive neoplasias of the uterine cervix are a matter of controversy in terms of their definition, prognostic factors and selection of treatment to minimize the risk of recurrences.
Mandić Aljoša, Mastilović Katarina, Ninčić Dejan P., Vujkov Tamara, Žikić Dragan 1, Živaljević Milica   +5 more
core   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Malignant priapism due to penile metastases. Case series and literature review [PDF]

, 2016
Malignant priapism secondary to penile metastases is a rare condition. This term was originally used by Peacock in 1938 to describe a condition of painful induration and erection of the penis due to metastatic infiltration by a neoplasm.
DE DOMINICIS, Carlo, DE LUCA, Francesco, Manzi, Emy, Maurizi, Angela, Ralph, David, Shabbir, Majed, Zacharakis, Evangelos, Zanghì, Antonio   +7 more
core   +2 more sources