Results 1 to 10 of about 97,823 (231)
npj Vaccines, 2023 Some studies have shown that lyophilization significantly improves the stability of mRNA-LNPs and enables long-term storage at 2–8 °C. However, there is little research on the lyophilization process of mRNA-lipid nanoparticles (LNPs).
Mingyuan Li +14 more
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Scientific Reports, 2021 Lyophilization is the “gold standard” for drying plant extracts, which is important in preserving their quality and extending their shelf-life. Compared to other methods of drying plant extracts, lyophilization is costlier due to equipment, material and ...
Nancy A. ElNaker +5 more
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mBio, 2023 Several recent attempts to improve the stability and immunogenicity of messenger RNA (mRNA) vaccines include the use of circular RNA (circRNA), targeted delivery, and lyophilization.
Jiawu Wan +7 more
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Mechanistic Modeling of Continuous Lyophilization for Biopharmaceutical Manufacturing [PDF]
Advanced ScienceLyophilization (aka freeze drying) is a typical process in (bio)pharmaceutical manufacturing used for improving the stability of various drug products, including its recent applications to mRNA vaccines.
Prakitr Srisuma +2 more
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Pharmaceutics, 2023 Bioavailability is an important biopharmaceutical characteristic of active pharmaceutical ingredients (APIs) that is often correlated with their solubility in water. One of the methods of increasing solubility is freeze drying (lyophilization).
Amir Taldaev +4 more
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Effect of Lyophilization Process on Nutritional Value of Meat By-Products
Applied Sciences, 2022 The meat industry generates large amounts of by-products, and their mass represents approximately one-third of the live weight of animals. Most by-products are disposed of and not used for processing, although they meet hygiene requirements and are ...
Ignė Juknienė +5 more
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Untargeted Plant Metabolomics: Evaluation of Lyophilization as a Sample Preparation Technique
Metabolites, 2023 Lyophilization is a common method used for stabilizing biological samples prior to storage or to concentrate extracts. However, it is possible that this process may alter the metabolic composition or lead to the loss of metabolites.
Christina Maisl +4 more
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Neural Regeneration Research, 2021 Both lyophilization and electrospinning are commonly used to make chitosan scaffolds. However, it remains unknown which method is better for cell growth. In this study, we established the following groups: (1) lyophilization group—chitosan scaffolds were
Yu-Xuan Wu +3 more
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Recent Development of Optimization of Lyophilization Process
Journal of Chemistry, 2019 The objective of this review is to survey the development of the optimization of lyophilization. The optimization study of the lyophilizer has been roughly developing by the order of (i) trial-and-error approach, (ii) process modeling using mathematical ...
Hidenori Kawasaki +2 more
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Pharmaceutics, 2021 Every day, thousands of patients receive erythrocyte concentrates (ECs). They are indispensable for modern medicine, despite their limited resource. Artificial oxygen carriers (AOCs) represent a promising approach to reduce the need for ECs.
Sarah Hester +3 more
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