Results 151 to 160 of about 1,085 (178)
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Trehalose Crystallization During Freeze-Drying: Implications On Lyoprotection
The Journal of Physical Chemistry Letters, 2009Lyoprotectants are stabilizers used to prevent denaturation of proteins during freeze-drying and subsequent storage. In order to be effective, lyoprotectants must be retained amorphous. The physical state of the lyoprotectant is usually characterized by powder X-ray diffractometry of the dried cake. While trehalose is widely used as a lyoprotectant, we
Prakash Sundaramurthi +1 more
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Journal of Liposome Research, 2014
The stability of liposomes in the form of dispersion is a major concern due to drug leakage and fusion or aggregation. The stability can be improved by lyophilization, but the stress induced by the lyophilization process can affect the integrity of liposomes.The objective of this study was to evaluate the lyoprotective effect of sucrose on drug leakage
Vinayagam, Kannan +3 more
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The stability of liposomes in the form of dispersion is a major concern due to drug leakage and fusion or aggregation. The stability can be improved by lyophilization, but the stress induced by the lyophilization process can affect the integrity of liposomes.The objective of this study was to evaluate the lyoprotective effect of sucrose on drug leakage
Vinayagam, Kannan +3 more
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Discriminating between dispersion and lyoprotection effects in biocatalysis in organic media
Canadian Journal of Chemistry, 2002The increment of activity and solubility in 1,4-dioxane of lipase B from Candida antarctica, lipase from Pseudomonas cepacia, and subtilisin, were investigated as a function of the methoxypoly(ethylene glycol)protein (PEGprotein) ratio employed during lyophilization.
Secundo F, Carrea G, Veronese FM
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Stability of Freeze-Dried Ovalbumin-Alginate Microspheres with Different Lyoprotectants
Research Journal of Pharmacy and Technology, 2016Stability and denaturation has been widely known as main disadvantages in the oral delivery of drug or protein. The aim of this research was to investigate stability of ovalbumin-alginate microspheres during production and storage. Ovalbumin-alginate microspheres were prepared using sodium alginate polymer, CaCl2 cross linker and different ...
Dewi Melani Hariyadi +2 more
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Lyoprotection de l'hémoglobine par le N-acétyl tryptophane
Revue Francaise de Transfusion et Immuno-hématologie, 1982Resume Des determinations de taux de methemoglobine, de differentes capacites de transport d'oxygene et de l'affinite pour ce ligand ont ete effectuees sur des hemoglobines lyophilisees en l'absence ou en presence de N-acetyl tryptophane et/ou d'α-D glucose.
J SAINTBLANCARD, P RAMBOURG, D DOUCET
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Sweet corn phytoglycogen dendrimers as a lyoprotectant for dry‐state protein storage
Journal of Biomedical Materials Research Part AAbstractProtein biotherapeutics typically require expensive cold‐chain storage to maintain their fold and function. Packaging proteins in the dry state via lyophilization can reduce these cold‐chain requirements. However, formulating proteins for lyophilization often requires extensive optimization of excipients that both maintain the protein folded ...
Junha Park +9 more
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Long term stability of freeze-dried, lyoprotected doxorubicin liposomes
European Journal of Pharmaceutics and Biopharmaceutics, 1997Abstract The aim of the present study was to determine which parameters influence the long term stability of freeze-dried doxorubicin (DXR) liposomes. The DXR content, DXR retention and average vesicle size of the rehydrated liposomes were examined as a function of storage temperature, lyoprotectant (sucrose, maltose, lactose and trehalose), residual
van Winden, E.C.A., Crommelin, D.J.A.
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Journal of Pharmaceutical Sciences, 2017
The concentration of maximally freeze-concentrated solutions [Formula: see text] and the corresponding glass transition temperature [Formula: see text] and ante-melting temperature [Formula: see text] of lyoprotectant solutions, are critical parameters for developing lyophilization process.
Mengjie, Xu +3 more
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The concentration of maximally freeze-concentrated solutions [Formula: see text] and the corresponding glass transition temperature [Formula: see text] and ante-melting temperature [Formula: see text] of lyoprotectant solutions, are critical parameters for developing lyophilization process.
Mengjie, Xu +3 more
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Freeze‐drying of lignin peroxidase: influence of lyoprotectants on enzyme activity and stability
Journal of Chemical Technology & Biotechnology, 2002AbstractThe effect of different lyoprotectants (sucrose, dimethyl‐succinate buffer (DMS), bovine serum albumin (BSA), mannitol and dextran, mw 60 kDa) on the stability of the enzyme lignin peroxidase (LiP, EC number: 1.11.1.‐), both during the freeze‐drying process and storage were investigated.
Antonio Capolongo +2 more
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Molecular Pharmaceutics
Many cell-based therapies, such as live biotherapeutic products (LBPs), require preservation of cell viability during manufacturing, transportation, and storage before being delivered to patients. Although lyophilization is a common strategy to improve storage stability, it can compromise cell viability, thus reducing therapeutic efficacy.
Haixi Cui +6 more
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Many cell-based therapies, such as live biotherapeutic products (LBPs), require preservation of cell viability during manufacturing, transportation, and storage before being delivered to patients. Although lyophilization is a common strategy to improve storage stability, it can compromise cell viability, thus reducing therapeutic efficacy.
Haixi Cui +6 more
openaire +2 more sources